目的:为了研究临床表现,病理特征,涎腺恶性肿瘤(SGMT)伴颅底转移的治疗和预后。
方法:对5例SGMT颅底转移患者进行回顾性研究。主要临床症状包括头痛,面瘫,耳朵听力损失。3例患者既往有SGMT切除史。所有患者均行术前计算机断层扫描(CT)和磁共振成像(MRI)。三名患者进行了开颅手术,5例患者均接受了放疗和化疗。
结果:两名患者被证实患有腺癌,一名患者经病理证实患有鳞状细胞癌,一名患者患有导管癌,一名患者患有腺泡细胞癌。一名患者在治疗2年后死亡,其余4例患者随访6~24个月,提示肿瘤大小未增大或无局部复发。
结论:SGMT伴颅底转移极为罕见,由于相似的成像特性,很容易误诊为脑膜瘤或神经鞘瘤。早期诊断,入侵程度,手术和联合化疗和放疗是该疾病的预后因素。
UNASSIGNED: To investigate the clinical performance, pathological characteristics, treatment and prognosis of salivary gland malignant tumor (SGMT) with skull base metastasis.
UNASSIGNED: Five SGMT patients with skull base metastasis were retrospectively studied. Major clinical symptoms included headache, facial paralysis, and ear hearing loss. Three patients had previous history of SGMT resection. All patients underwent preoperative computed tomography (CT) and magnetic resonance imaging (MRI). Craniotomy was performed in three patients, and all the five patients underwent radiotherapy and chemotherapy.
UNASSIGNED: Two patients were confirmed as having adenocarcinoma, one patient was pathologically confirmed to have squamous cell carcinoma, one patient had ductal carcinoma, and one patient had acinar cell carcinoma. One patient died after 2 years of treatment, and the remaining 4 patients were followed up for 6 ∼ 24 months, suggesting that the tumor size was not enlarged or showed no local recurrence.
UNASSIGNED: SGMT with skull base metastasis is extremely rare, and due to similar imaging characteristics, it can be easily misdiagnosed as meningioma or schwannoma. Early diagnosis, extent of invasion, surgery and combination of chemotherapy and radiotherapy are the prognostic factors of the disease.