■精神分裂症是一种具有高遗传性的毁灭性精神疾病。越来越多的易感基因与精神分裂症相关,以及它们相应的SNP基因座,已被全基因组关联研究揭示。然而,使用SNP作为疾病和诊断的预测因子仍然很困难.这里,我们旨在揭示中国人群的易感性SNP,并构建精神分裂症的预测模型.
■共有210名参与者,包括70名精神分裂症患者,70名双相情感障碍患者,和70个健康对照,参加了这项研究。我们使用已发表的精神分裂症风险位点估计了14个SNP,并使用这些SNP通过比较基因型频率和回归来建立预测精神分裂症的模型。我们使用ROC曲线评估诊断模型在精神分裂症和对照组患者中的疗效,然后使用70例双相情感障碍患者评估模型的鉴别诊断效能。
■选择5个SNP构建模型:rs148415900,rs71428218,rs4666990,rs112222723和rs1716180。相关分析结果表明,与风险SNP为0相比,风险SNP为3与精神分裂症风险增加相关(OR=13.00,95%CI:2.35-71.84,p=0.003).该精神分裂症预测模型的ROC-AUC为0.719(95%CI:0.634-0.804),最大的灵敏度和特异性为60%和80%,分别。该模型区分精神分裂症和双相情感障碍的ROC-AUC为0.591(95%CI:0.497-0.686),最大的敏感性和特异性分别为60%和55.7%,分别。
■SNP风险评分预测模型在预测精神分裂症方面具有良好的性能。据我们所知,以前的研究没有应用基于SNP的模型来区分精神分裂症和其他精神疾病.它可能有几个潜在的临床应用,包括塑造疾病诊断,治疗,和结果。
UNASSIGNED: Schizophrenia is a devastating mental disease with high heritability. A growing number of susceptibility genes associated with schizophrenia, as well as their corresponding SNPs loci, have been revealed by genome-wide association studies. However, using SNPs as predictors of disease and diagnosis remains difficult. Here, we aimed to uncover susceptibility SNPs in a Chinese population and to construct a prediction model for schizophrenia.
UNASSIGNED: A total of 210 participants, including 70 patients with schizophrenia, 70 patients with bipolar disorder, and 70 healthy controls, were enrolled in this study. We estimated 14 SNPs using published risk loci of schizophrenia, and used these SNPs to build a model for predicting schizophrenia via comparison of genotype frequencies and regression. We evaluated the efficacy of the diagnostic model in schizophrenia and control patients using ROC curves and then used the 70 patients with bipolar disorder to evaluate the model\'s differential diagnostic efficacy.
UNASSIGNED: 5 SNPs were selected to construct the model: rs148415900, rs71428218, rs4666990, rs112222723 and rs1716180. Correlation analysis results suggested that, compared with the risk
SNP of 0, the risk
SNP of 3 was associated with an increased risk of schizophrenia (OR = 13.00, 95% CI: 2.35-71.84, p = 0.003). The ROC-AUC of this prediction model for schizophrenia was 0.719 (95% CI: 0.634-0.804), with the greatest sensitivity and specificity being 60% and 80%, respectively. The ROC-AUC of the model in distinguishing between schizophrenia and bipolar disorder was 0.591 (95% CI: 0.497-0.686), with the greatest sensitivity and specificity being 60% and 55.7%, respectively.
UNASSIGNED: The
SNP risk score prediction model had good performance in predicting schizophrenia. To the best of our knowledge, previous studies have not applied
SNP-based models to differentiate between cases of schizophrenia and other mental illnesses. It could have several potential clinical applications, including shaping disease diagnosis, treatment, and outcomes.