right hemicolectomy

右半结肠切除术
  • 文章类型: Journal Article
    背景:缺乏关于右半结肠切除术中切除回肠末端长度的文献。因此,我们旨在确定接受右半结肠切除术的患者的平均回肠环长度以及这种变化对术后并发症和长期肿瘤结局的影响.
    方法:从前瞻性数据库中对2011年1月至2018年12月在三级医院进行的结肠癌右半结肠切除术进行回顾性分析。根据切除的回肠在7cm以上和以下的平均长度建立了两个患者组。比较两组临床病理资料,术后并发症,死亡率,长期总生存期(OS)和无病生存期(DFS)。分析了影响OS和DFS的因素。
    结果:该研究包括217名患者。体重指数(BMI)值在回肠切除长度>7cm组中明显更高(p=0.009)。病理N期,肿瘤直径,回肠切除长度>7cm组的转移性淋巴结数量显着增加(分别为p=0.001,p=0.001和p=0.026)。两组术后并发症和死亡率差异无统计学意义。所有患者平均随访时间为61.2个月(2-120)。死亡总数为29例(11.7%),60个月OS为83.5%,50个月DFS为81.8%。两组间OS和DFS率无显著差异(p>0.05)。
    结论:右半结肠切除术中回肠远端过度切除对预后和并发症没有任何益处。在我们的研究中,回肠切除长度和接近它的值似乎就足够了。
    BACKGROUND: There is a lack of literature on the length of the terminal ileum to be resected in right hemicolectomy for colon cancer. Therefore, we aimed to determine the mean ileal loop length and the effect of this variation on postoperative complications and long-term oncological outcomes in patients who underwent right hemicolectomy.
    METHODS: Right hemicolectomy surgeries performed for colon cancer in a tertiary care hospital between January 2011 and December 2018 were retrospectively analyzed from a prospective database. Two patient groups were established based on the mean length of the resected ileum above and below 7 cm. The two groups were compared for clinicopathological data, postoperative complications, mortality, long-term overall survival (OS) and disease-free survival (DFS). The factors contributing to OS and DFS were analyzed.
    RESULTS: The study included 217 patients. Body mass index (BMI) values were significantly higher in the ileum resection length > 7 cm group (p = 0.009). Pathological N stage, tumor diameter, and number of metastatic lymph nodes were significantly higher in the ileum resection length > 7 cm group (p = 0.001, p = 0.001, and p = 0.026, respectively). There was no significant difference for postoperative complication and mortality rates between the two groups. The mean follow-up period was 61.2 months (2-120) in all patients. The total number of deaths was 29 (11.7%) while the 60-month OS was 83.5% and 50-month DFS was 81.8%. There was no significant difference between the groups in terms of OS and DFS rates (p > 0.05).
    CONCLUSIONS: Excessive resection of the distal ileum in right hemicolectomy does not provide any benefit in terms of prognosis and complications.The ileum resection length and values close to it in our study appear to be sufficient.
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  • 文章类型: Journal Article
    背景:我们的目的是比较体外吻合术(ECA)和体内吻合术(ICA)在腹腔镜右半结肠切除术中的效果和成本效益。
    方法:确定2018年1月至2022年12月接受择期腹腔镜右半结肠切除术治疗结肠癌的患者。非癌症诊断,紧急手术或同步切除其他器官被排除.手术特点,围手术期结果,比较了长期生存率和住院费用.采用增量成本-效果比(ICER)评价成本-效果。
    结果:总共223例患者(175例ECA,48个ICA)被包括在分析中。两组均表现出相当的基线患者,合并症,和肿瘤特征。病理TMN分期分布,肿瘤最大尺寸,总淋巴结收获和切除边缘长度在统计学上相似.与ECA相比,ICA的中位手术时间更长(255分钟与220分钟,P<0.001)。胃肠道恢复的时间更快,ICA组的中位住院时间较短(4.0天对5.0天,P=0.001)。总体并发症发生率相当。ICA与较高的手术费用相关(6301.57英镑对4998.52英镑,P<0.001),但病房住宿费用(1679.05英镑对2420.15英镑,P=0.001)和治疗费用(3774.55英镑对4895.14英镑,P=0.009)较低,与ECA相比,总成本降低了4.5%。ICER-3323.58英镑显示ICA比ECA更具成本效益,跨越一系列支付意愿门槛。
    结论:与ECA相比,腹腔镜右半结肠切除术中的ICA与术后恢复更快相关,并且可能更具成本效益。尽管手术成本增加。
    BACKGROUND: We aimed to compare outcomes and cost effectiveness of extra-corporeal anastomosis (ECA) versus intra-corporeal anastomosis (ICA) for laparoscopic right hemicolectomy using the National Surgical Quality Improvement Programme data.
    METHODS: Patients who underwent elective laparoscopic right hemicolectomy for colon cancer from January 2018 to December 2022 were identified. Non-cancer diagnoses, emergency procedures or synchronous resection of other organs were excluded. Surgical characteristics, peri-operative outcomes, long-term survival and hospitalisation costs were compared. Incremental cost-effectiveness ratio (ICER) was used to evaluate cost-effectiveness.
    RESULTS: A total of 223 patients (175 ECA, 48 ICA) were included in the analysis. Both cohorts exhibited comparable baseline patient, comorbidity, and tumour characteristics. Distribution of pathological TMN stage, tumour largest dimension, total lymph node harvest and resection margin lengths were statistically similar. ICA was associated with a longer median operative duration compared with ECA (255 min vs. 220 min, P < 0.001). There was a quicker time to gastrointestinal recovery, with a shorter median hospital stay in the ICA group (4.0 versus 5.0 days, P = 0.001). Overall complication rates were comparable. ICA was associated with a higher surgical procedure cost (£6301.57 versus £4998.52, P < 0.001), but lower costs for ward accommodation (£1679.05 versus £2420.15, P = 0.001) and treatment (£3774.55 versus £4895.14, P = 0.009), with a 4.5% reduced overall cost compared with ECA. The ICER of -£3323.58 showed ICA to be more cost effective than ECA, across a range of willingness-to-pay thresholds.
    CONCLUSIONS: ICA in laparoscopic right hemicolectomy is associated with quicker post-operative recovery and may be more cost effective compared with ECA, despite increased operative costs.
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  • 文章类型: Case Reports
    盲肠扭转是妊娠梗阻的罕见原因。它占所有肠梗阻的1.5%。诊断具有挑战性,并导致母亲和胎儿的发病率和死亡率增加。此病例报告将强调这种情况的危及生命的性质,并强调早期诊断和干预的至关重要性。
    方法:一名30岁的gravida-3para-2患者表现为24小时的腹痛。她有腹胀,呕吐和发烧。她有05个月的闭经。过去的医疗和手术史是负面的。她的生命体征紊乱,腹部全身有压痛。超声显示腹部气态和子宫内的存活胎儿。剖腹手术显示坏疽性盲肠扭转。进行了右半结肠切除术和端对侧回肠横结肠吻合术。她在12小时后驱逐了一个死亡的胎儿。她以良好的临床状态出院。
    结论:盲肠扭转涉及升结肠的轴向旋转,盲肠,和相关肠系膜的末端回肠。妊娠是盲肠扭转的诱发因素之一。由于非特异性表现,诊断通常具有挑战性。放射学程序有助于诊断。主要治疗是手术干预。
    结论:盲肠扭转是一种罕见的危及生命的妊娠梗阻原因。这是一个紧急情况,早期诊断和干预对降低发病率和死亡率至关重要。最有效的治疗方法是手术切除。
    UNASSIGNED: Cecal volvulus is a rare cause of obstruction in pregnancy. It accounts for ∼1.5 % of all intestinal obstructions. The diagnosis is challenging and causes increased morbidity and mortality to the mother and fetus. This case report will highlight the life-threatening nature of this condition and emphasize the critical importance of early diagnosis and intervention.
    METHODS: A 30-year-old gravida-3 para-2 patient presented with colicky abdominal pain of 24 h duration. She had associated abdominal distension, vomiting and fever. She had amenorrhea of 05-months. The past medical and surgical histories were negative. Her vital signs were deranged and had tenderness all over the abdomen. Ultrasound showed gaseous abdomen and viable fetus in the uterus. Laparotomy has revealed gangrenous cecal volvulus. A right hemicolectomy and end-to-side ileo-transverse colon anastomosis were performed. She expelled a dead fetus after 12 h. She was discharged in good clinical status.
    CONCLUSIONS: Cecal volvulus involves axial rotation of the ascending colon, cecum, and terminal ileum about associated mesentery. Pregnancy is among the pre-disposing factor for cecal volvulus. The diagnosis is often challenging because of non-specific presentations. Radiologic procedures are helpful in the diagnosis. The primary treatment is surgical intervention.
    CONCLUSIONS: Cecal volvulus is a rare life-threatening cause of obstruction in pregnancy. It is an emergency situation, and early diagnosis and intervention are crucial to decreasing morbidity and mortality. The most effective treatment is surgical resection.
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  • 文章类型: English Abstract
    The use of robotic surgical methods for performing right-sided hemicolectomy has been somewhat controversial, primarily due to concerns related to costs. The purpose of this study is to document the initial robotic right hemicolectomies conducted at our institution and to compare them with a laparoscopic reference group. A significant focus of this study is the detailed analysis of the costs associated with both techniques within the German healthcare system.Surgical and cost-related data for 34 cases each for robotic and laparoscopic right-sided hemicolectomy performed at Nürnberg Hospital were compared. This comparison was conducted through a retrospective single-center case-matched analysis. Cost analysis was carried out following the current guidelines provided by the Institute for the Hospital Remuneration System (InEK) of Germany.The average age of the patient cohort was 70 years, with a male patient proportion of 57.4%. Analysis of perioperative parameters indicated similar outcomes for both surgical techniques. Regarding the incidence of complications of Clavien-Dindo stages III-V (8.8% vs. 17.6%; p = 0.48), a positive trend towards robotic surgery was observed. The cost analysis showed nearly identical total costs for the selected cases in both groups (mean €13,423 vs. €13,424; p = 1.00), with the most significant cost difference noted in surgical (operative) costs (€5,779 vs. €3,521; p < 0.01). The lower costs for laparoscopic cases were primarily due to the reduced material costs (mean €2,657 vs. €702; p < 0.05).In conclusion, both surgical approaches are clinically equivalent, with only minor differences in the total case costs.
    UNASSIGNED: Der Einsatz robotischer Operationsmethoden bei der Durchführung rechtsseitiger Hemikolektomien ist bislang unter anderem aufgrund von Kostenfragen umstritten. Diese Arbeit hat zum Ziel, die ersten an dieser Institution durchgeführten robotischen Operationen dieser Art zu erfassen und mit einer laparoskopischen Referenzgruppe zu vergleichen. Ein wichtiger Aspekt dabei ist die detaillierte Erfassung der Kostenpunkte beider Verfahren.Es wurden die operations- und kostenbezogenen Daten von je 34 robotisch und laparoskopisch am Klinikum Nürnberg durchgeführten rechtsseitigen Hemikolektomien erfasst. Diese wurden im Rahmen einer retrospektiven Single-center-case-matched-Analyse verglichen. Die Erfassung der Kosten erfolgte anhand des aktuellen Kalkulationshandbuches des InEK.In der betrachteten Patientengruppe liegt der Altersdurchschnitt bei 70 Jahren. Der Anteil männlicher Patienten beträgt 57,4 %. Die Auswertung der perioperativen Parameter zeigte ein gleichwertiges Outcome, unabhängig von dem gewählten Verfahren. Hinsichtlich der Anzahl an Komplikationen der Clavien-Dindo-Stadien III bis V (8,8 % vs. 17,6 %; p = 0,48) ist ein positiver Trend zur Roboterchirurgie zu verzeichnen. Die Kostenanalyse zeigt fast identische Fallgesamtkosten (Mittelwert; 13.423 € vs. 13.424 €; p = 1,00) in der hier betrachteten Fallauswahl. Der größte Unterschied konnte erwartbar bei den Operationskosten (Mittelwert 5779 € vs. 3521 €; p < 0,05) beobachtet werden. Die geringeren Kosten der laparoskopischen Fälle lassen sich hier vor allem auf die niedrigeren Materialkosten (Mittelwert; 2657 € vs. 702 €; p < 0,05) zurückführen.Zusammenfassend lässt sich sagen, dass beide Operationsverfahren bei klinischer Gleichwertigkeit nur geringe Unterschiede in den Gesamtfallkosten aufweisen.
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  • 文章类型: Journal Article
    背景:在腹腔镜右半结肠切除术(LRH)中,可以选择体外吻合术(EA)或体内吻合术(IA)进行消化道重建。然而,LRH联合IA治疗超重右侧结肠癌(RCC)是否可行和有益尚不清楚.本研究旨在探讨IA在LRH中用于超重RCC的可行性和优势。
    方法:48例连续超重的RCC患者接受IA的LRH,与48例连续接受EA的LRH患者相匹配。收集和分析临床和手术数据。
    结果:术后并发症发生率EA组为20.8%(10/48),IA组为14.6%(7/48)。没有统计学差异。与EA组相比,IA组患者表现出更快的气体(40.27.8h与45.6+7.9小时,P=0.001)和粪便排出量(4.0+1.2dvs.4.5+1.1d,P=0.040),较短的辅助切口(5.3+1.3厘米与7.5+1.2厘米,P=0.000),和较少的镇痛剂使用(3.3+1.3dvs.4.0+1.3d,P=0.012)。手术时间无明显差异,失血,或术后住院。在IA组中,前三分之一的病例表现出更长的手术时间(228.4+29.3分钟),而中期(191.0+35.0分钟,P=0.003)和最后三分之一的患者(182.220.7分钟,P=0.000)。
    结论:LRH与IA是可行和安全的超重RCC,肠功能恢复更快,疼痛更少。合并IA的某些LRH病例的积累将有助于外科手术并减少手术时间。
    BACKGROUND: Either extracorporeal anastomosis (EA) or intracorporeal anastomosis (IA) could be selected for digestive reconstruction in laparoscopic right hemicolectomy (LRH). However, whether LRH with IA is feasible and beneficial for overweight right-side colon cancer (RCC) is unclear. This study aims to investigate the feasibility and advantage of IA in LRH for overweight RCC.
    METHODS: Forty-eight consecutive overweight RCC patients undergoing LRH with IA were matched with 48 consecutive cases undergoing LRH with EA. Both clinical and surgical data were collected and analyzed.
    RESULTS: The incidence of postoperative complications was 20.8% (10/48) in the EA group and 14.6% (7/48) in the IA group respectively, with no statistical difference. Compared to the EA group, patients in the IA group revealed faster gas (40.2 + 7.8 h vs. 45.6 + 7.9 h, P = 0.001) and stool discharge (4.0 + 1.2 d vs. 4.5 + 1.1 d, P = 0.040), shorter assisted incision (5.3 + 1.3 cm vs. 7.5 + 1.2 cm, P = 0.000), and less analgesic used (3.3 + 1.3 d vs. 4.0 + 1.3 d, P = 0.012). There were no significant differences in operation time, blood loss, or postoperative hospital stays. In the IA group, the first one third of cases presented longer operation time (228.4 + 29.3 min) compared to the middle (191.0 + 35.0 min, P = 0.003) and the last one third of patients (182.2 + 20.7 min, P = 0.000).
    CONCLUSIONS: LRH with IA is feasible and safe for overweight RCC, with faster bowel function recovery and less pain. Accumulation of certain cases of LRH with IA will facilitate surgical procedures and reduce operation time.
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  • 文章类型: Case Reports
    肠套叠是一种以肠的近端段内陷到远端段为特征的病症。在成年人中,肠套叠通常与导联点有关。最令人担忧的导火索是恶性肿瘤。这里,我们介绍一例57岁女性结肠腺癌继发回肠肠套叠的病例.偶然发现心动过缓后,患者被送往急诊科,心率约为每分钟40次。她经历了几周的抽筋,右下腹腹痛,头昏眼花,疲劳,还有心悸.计算机断层扫描显示回肠肠套叠。放置半永久性右锁骨下起搏器后,患者接受了右半结肠切除术.手术结果与可疑的回肠肠套叠一致,该肠套叠是由右盲肠中的肿块引起的,该肿块涉及阑尾口和回肠瓣,并通过固有肌层侵入浆膜下组织。肿块被切除并送去病理学检查,在那里它被分类为II期结肠腺癌。该病例突出了肠套叠的非特异性表现,该表现仅由于偶然的心动过缓而被发现。
    Intussusception is a condition characterized by the invagination of a proximal segment of the intestine into a distal segment. In adults, intussusception is commonly associated with a lead point. The most alarming lead point is an obstructing malignancy. Here, we present the case of a 57-year-old woman with ileocolic intussusception secondary to colonic adenocarcinoma. The patient presented to the emergency department following an incidental finding of bradycardia, with a heart rate of around 40 beats per minute. She presented with several weeks of cramping, right lower quadrant abdominal pain, lightheadedness, fatigue, and palpitations. A computed tomography scan revealed ileocolic intussusception. After the placement of a semi-permanent right subclavian pacer, the patient underwent a right hemicolectomy. Surgical findings were consistent with ileocolic intussusception suspicious of being initiated by a mass in the right cecum involving the appendiceal orifice and ileocecal valve that invaded through the muscularis propria into subserosal tissue. The mass was resected and sent to pathology, where it was classified as stage II colonic adenocarcinoma. This case highlights a nonspecific presentation of intussusception that was only identified due to incidental bradycardia.
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  • 文章类型: Journal Article
    结直肠癌,全球第三大常见癌症,影响40-45%的右侧患者。手术,特别是微创方法,如腹腔镜和机器人手术,是首选的治疗方法。然而,这些技术存在技术复杂性。血管分支模式的解剖复杂性和变化带来了挑战,特别是对于经验不足的外科医生。CoDIG2是一项全国性的观察性研究,涉及76个专门的意大利普外科部门,重点是结直肠手术。指示这些中心维持其标准的手术和临床实践。这项研究的目的是分析接受腹腔镜右结肠切除术的意大利患者的术中血管解剖结构,并探讨意大利外科医生使用的结扎技术。外科医生报告了616例患者的右结肠血管化信息和368例患者的RCA手术解剖信息。53例(10.8%)患者术中无RCA。评估期间根据Yada分类(1-4型)对右结肠动脉(RCA)进行分类,术中评估显示Yada1型是最常见的类型(55.2%),而放射学评估显示2型患病率较高.此外,与肠系膜上静脉(SMV)相比,根据术中和对比增强CT检查,RCA更常位于前位;术中检查发现59.9%位于前位,术前对比增强CT检查发现40.1%位于同一位置。右半结肠血管化,包括缺失的树枝,额外的分支,共享树干,和肠系膜静脉的后上段,表现出显著的变化。为了了解血管变异,术前放射学研究是必要的,尽管术中和放射学评估之间没有一致性,这是介入前放射学评估(PII)的局限性,因为肿瘤分期总是需要它.这种方法对于没有经验的外科医生来说尤其重要,以避免潜在的并发症。比如有问题的出血。
    Colorectal cancer, the third most common cancer worldwide, affects 40-45% of patients on the right side. Surgery, especially minimally invasive methods such as laparoscopic and robotic procedures, is the preferred treatment. However, these techniques present technical complications. The anatomical complexity and variations in vessel branching patterns pose challenges, particularly for less experienced surgeons. The CoDIG 2 is a nationwide observational study involving 76 specialized Italian general surgery departments focused on colorectal surgery. The centres were directed to maintain their standard surgical and clinical practices. The aim of this study was to analyse the intraoperative vascular anatomy of Italian patients who underwent laparoscopic right colectomy and explore the ligature techniques used by Italian surgeons. Surgeons reported information about vascularization of the right colon for 616 patients and about surgical anatomy of RCA for 368 patients. Fifty-three patients (10.8%) showed no RCA intraoperatively. The right colic artery (RCA) was categorized according to the Yada classification (types 1-4) during evaluation, and intraoperative assessments revealed that Yada type 1 was the most common type (55.2%), while radiologic evaluations revealed a higher prevalence of type 2. Furthermore, compared with the superior mesenteric vein (SMV), the RCA is more often located anteriorly according to intraoperative and contrast-enhanced CT examination; 59.9% were found in the anterior position during intraoperative examination, while 40.1% were found in the same position on preoperative contrast-enhanced CT. Vascularization of the right colon, including missing branches, additional branches, shared trunks, and retro-superior courses of the mesenteric vein, exhibited notable variations. To understand vascular variations, a preoperative radiological study is necessary; although there was no concordance between the intraoperative and radiological evaluations, this is a limitation of preinterventional radiological evaluation (PII) because it is always needed for oncological staging. This approach is especially critical for inexperienced surgeons to avoid potential complications, such as problematic bleeding.
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  • 文章类型: Journal Article
    腹腔镜下完整结肠系膜切除术与中央血管结扎因其在结肠癌手术中的肿瘤学益处而被广泛接受。然而,腹腔镜右半结肠切除术涉及在手术干周围解剖期间血管损伤的风险。这种技术难题归因于常规腹腔镜钳的有限运动。尽管机器人设备可以克服腹腔镜设备的受限运动,它们尚未广泛使用。ArtiSential是一种关节式腹腔镜器械,具有双关节末端执行器,可实现广泛的运动,精确反映外科医生的手指运动,并且旨在弥补传统腹腔镜工具的缺点。本研究通过比较作者的腹腔镜手术,证明了关节器械在腹腔镜右半结肠切除术中的实用性,使用关节器械,用机器人程序。可以以与机器人设备几乎相同的方式成功地操纵铰接腹腔镜器械,因此,代表机器人手术的可行替代方案。
    在线版本包含补充材料,可在10.1007/s13691-024-00654-w获得。
    Laparoscopic complete mesocolic excision with central vessel ligation has been widely accepted for its oncological benefits in colon cancer surgery. However, laparoscopic right hemicolectomy involves a risk for vascular injury during dissection around the surgical trunk. This technical difficulty has been attributed to the limited movement of conventional laparoscopic forceps. Although robotic devices can overcome the restricted motion of laparoscopic devices, they are not yet widely used. The ArtiSential is an articulating laparoscopic instrument that has a two-joint end-effector that enables a wide range of motion precisely reflecting the surgeon\'s finger movements, and is designed to compensate for the drawbacks of conventional laparoscopic tools. The present study demonstrated the utility of articulating instruments in laparoscopic right hemicolectomy by comparing the authors\' laparoscopic procedures, using articulating instruments, with robotic procedures. Articulating laparoscopic instruments can be successfully maneuvered in virtually the same manner as robotic devices and, as such, represent a viable alternative to robotic surgery.
    UNASSIGNED: The online version contains supplementary material available at 10.1007/s13691-024-00654-w.
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  • 文章类型: Case Reports
    盲肠扭转是一种罕见的,由肠系膜轴周围的肠缠结引起的危及生命的肠梗阻形式,损害血液供应并导致阻塞和缺血。由于其高度可变的临床表现和鉴别诊断,诊断具有挑战性。这可能会延迟及时干预。这是一例89岁女性的病例报告,她有两天的右下象限腹痛病史,恶心,暂时失去意识。她还报告了慢性便秘的病史。临床检查和影像学检查考虑肠梗阻,促使进一步调查。X线平片和腹部CT证实肠梗阻,怀疑有扭转.盲肠和乙状结肠扭转之间的诊断不确定性促使结肠镜检查,排除乙状结肠扭转.紧急剖腹手术显示盲肠扭转和盲肠扩张,伴有缺血性改变,但无坏死。进行了右半结肠切除术,患者术后恢复良好。本病例报告旨在扩大盲肠扭转的医学知识。它强调了诊断和管理这种情况的挑战,并强调了及时识别和手术干预以改善患者预后的重要性。
    Cecal volvulus is a rare, life-threatening form of bowel obstruction caused by the entanglement of the bowel around the mesenteric axis, compromising blood supply and leading to obstruction and ischemia. The diagnosis is challenging due to its highly variable clinical presentation and differential diagnoses, which may delay timely intervention. This is a case report of an 89-year-old woman who presented with a two-day history of lower right quadrant abdominal pain, nausea, and a temporary loss of consciousness. She also reported a history of chronic constipation. Clinical examination and imaging were suggestive of bowel obstruction, prompting further investigation. Plain radiography and abdominal CT confirmed bowel obstruction, with suspicion of volvulus. The diagnostic uncertainty between cecal and sigmoid volvulus prompted a colonoscopy, which excluded sigmoid volvulus. Emergency laparotomy revealed cecal volvulus and a distended cecum with ischemic changes but without necrosis. A right hemicolectomy was performed, and the patient recovered well postoperatively. This case report aims to expand the medical knowledge around the topic of cecal volvulus. It underscores the challenges in diagnosing and managing this condition and emphasizes the importance of prompt recognition and surgical intervention to improve patient outcomes.
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  • 文章类型: Case Reports
    阑尾粘液性肿瘤,占不到1%的胃肠道肿瘤,是异构实体。他们可能无症状,偶然发现,或由于粘蛋白积累而表现为大肿瘤。缺乏标准化治疗使管理复杂化。影像学检查,尤其是CT扫描,对诊断和随访至关重要。该病例报告介绍了两例临床病例,其中六岁和七岁的妇女有下消化道出血史,实验室研究中的轻度贫血,结肠镜检查不完整。诊断,通过CT扫描证实,导致了在这两种情况下进行手术干预的决定,包括腹腔镜右半结肠切除术与回肠吻合术。随后,组织病理学报告证实了高度阑尾粘液性肿瘤的诊断,并制定了随访计划,每6个月进行一次影像学检查,2年无复发.超过50%的阑尾肿瘤是源自低度粘液性肿瘤的粘液性肿瘤。鉴于低淋巴结侵犯(2%),如果切除整个肿瘤,阑尾切除术可能就足够了。对于较大的肿瘤或高级别肿瘤保留广泛切除或右半结肠切除术,以最大程度地减少局部复发风险。伴有无细胞黏液蛋白和腹膜浸润的黏液性肿瘤可能需要细胞减灭术或右半结肠切除术,而患有粘液上皮的患者可能需要腹腔热化疗(HIPEC),因为有局部复发的风险,由于额外的阑尾上皮细胞的存在而恶化。无病生存期和总生存期取决于治疗和初始病变特征。据报道,低度粘液性肿瘤的五年生存率为86%。后续方法缺乏理想的标准,在头六年中,通常每六个月至一年进行一次体格检查和影像学检查。
    Appendicular mucinous neoplasms, constituting less than 1% of gastrointestinal tract neoplasms, are heterogeneous entities. They may be asymptomatic, discovered incidentally, or present as large tumors due to mucin accumulation. The lack of standardized treatment complicates management. Imaging studies, particularly CT scans, are crucial for diagnosis and follow-up. This case report presents two clinical cases of women in their sixth and seventh decades of life with a history of lower gastrointestinal bleeding, mild anemia in laboratory studies, and incomplete colonoscopies. The diagnosis, confirmed through CT scans, led to the decision for surgical intervention in both cases, involving laparoscopic right hemicolectomy with ileotransverse anastomosis. Subsequently, histopathological reports confirmed the diagnosis of high-grade appendicular mucinous neoplasms, and a follow-up plan was established with imaging studies every six months with no recurrence at two years. Over 50% of appendicular tumors are mucinous neoplasms originating from low-grade mucinous neoplasms. Given the low lymph node invasion (2%), appendectomy may suffice if the entire tumor is excised. Extensive resections or right hemicolectomy are reserved for larger tumors or high-grade neoplasms to minimize local recurrence risk. Mucinous neoplasms with acellular mucin and peritoneal invasion may require cytoreduction or right hemicolectomy, while those with mucinous epithelium may need hyperthermic intraperitoneal chemotherapy (HIPEC) due to the risk of local recurrence, worsened by the presence of extra appendiceal epithelial cells. Disease-free and overall survival depend on treatment and initial lesion characterization. A five-year survival rate of 86% is reported for low-grade mucinous neoplasms. Follow-up approaches lack an ideal standard, generally involving physical examinations and imaging studies every six months to one year during the first six years.
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