■尚不清楚胃组织病理学是否与结肠肿瘤的发生有关。我们旨在阐明胃组织病理学与不同类型的结直肠息肉(CP)和结直肠癌(CRC)之间的关系。以及各种胃组织病理学是否是不同类型CP和CRC的危险因素。
■对2019年8月1日至2020年5月31日在绍兴市人民医院同时接受胃镜和结肠镜检查的5,986例患者进行了回顾性横断面研究。采用Pearsonχ2检验分析不同类型CP和CRC的各种胃组织病理学发生情况,和logistic回归用于确定各种胃组织病理学是否是不同类型CP和CRC的危险因素。
■对于中国人口,男性(优势比[OR]1.67,95%置信区间[CI]1.41-1.97,P<0.001)和年龄(OR1.03,95%CI1.02-1.04,P<0.001)是非腺瘤性息肉(NAP)的危险因素,但幽门螺杆菌(H.pylori)和各种胃组织病理学在NAP中与正常组相比没有显着。然而,值得注意的是,类似于男性和老年,幽门螺杆菌(OR1.22,95%CI1.08-1.38,P=0.002),低度上皮内瘤变(LGIN)(OR1.79,95%CI1.21-2.66,P=0.004),胃底腺息肉(FGPs)(OR1.44,95%CI1.11-1.87,P=0.007),增生/炎性胃息肉(GHP或GIP)(OR1.50,95%CI1.06-2.12,P=0.022),和萎缩/肠上皮化生(AG或IM)(OR1.27,95%CI1.13-1.43,P<0.001)都是结直肠腺瘤性息肉(AP)的危险因素。然而,结直肠癌结果显示高龄(OR1.13,95%CI1.10-1.16,P<0.001)和幽门螺杆菌(OR1.67,95%CI0.99-2.75,P<0.05)是结直肠癌的危险因素(OR1.67,95%CI0.99-2.75,P<0.05),但性别和各种胃组织病理学(P>0.05)。
■胃组织病理学,例如AG或IM,LGIN,FGP,和GHP或GIP,是AP的危险因素,但对于国家行动方案和儿童权利委员会,提示胃组织病理学对中国人群AP具有潜在预测价值。
UNASSIGNED: It remains unknown whether gastric histopathology is associated with the occurrence of colonic neoplasms. We aimed to clarify the association between gastric histopathology and different types of colorectal polyps (CP) and colorectal cancer (CRC), and whether various gastric histopathologies are risk factors for different types of CP and CRC.
UNASSIGNED: A retrospective cross-sectional study was conducted on 5,986 patients who underwent gastroscopy and colonoscopy simultaneously at Shaoxing People\'s Hospital from August 1, 2019, to May 31, 2020. The Pearson χ2 test was used to analyze the occurrence of various gastric histopathologies in different types of CP and CRC, and logistic regression was used to determine whether various gastric histopathologies were risk factors for different types of CP and CRC.
UNASSIGNED: For the Chinese population, male sex (odds ratio [OR] 1.67, 95% confidence interval [CI] 1.41-1.97, P < 0.001) and old age (OR 1.03, 95% CI 1.02-1.04, P < 0.001) were risk factors for non-adenomatous polyps (NAP), but Helicobacter pylori (H. pylori) and various gastric histopathologies were not significant in the NAP compared with the normal group. Nevertheless, it is noteworthy that, similar to male sex and old age, H. pylori (OR 1.22, 95% CI 1.08-1.38, P = 0.002), low-grade intraepithelial neoplasia (LGIN) (OR 1.79, 95% CI 1.21-2.66, P = 0.004), gastric fundus gland polyps (FGPs) (OR 1.44, 95% CI 1.11-1.87, P = 0.007), hyperplastic/inflammatory gastric polyps (GHP or GIP) (OR 1.50, 95% CI 1.06-2.12, P = 0.022), and atrophy/intestinal metaplasia (AG or IM) (OR 1.27, 95% CI 1.13-1.43, P < 0.001) were all risk factors for colorectal adenomatous polyps (AP). However, the results of CRC showed that old age (OR 1.13, 95% CI 1.10-1.16, P < 0.001) and H. pylori (OR 1.67, 95% CI 0.99-2.75, P < 0.05) were risk factors for CRC (OR 1.67, 95% CI 0.99-2.75, P < 0.05), but not sex and various gastric histopathologies (P > 0.05).
UNASSIGNED: Gastric histopathology, such as AG or IM, LGIN, FGP, and GHP or GIP, were risk factors for AP, but not for NAP and CRC, indicating that gastric histopathology has potential predictive value for AP in the Chinese population.