■电路训练是一种锻炼模式,这可能包括耐力和阻力成分。有前提的是,这两种模式的结合会带来额外的好处,特别是在提高胰岛素敏感性方面。视黄醇结合蛋白4(RBP4)可抑制骨骼肌胰岛素代谢途径的信号传导,从而发展胰岛素抵抗。这项研究旨在评估中等强度的循环训练结合力量和耐力运动是否会引起组织胰岛素敏感性的变化。碳水化合物和脂质代谢,胰岛素抵抗妇女的血清RBP4水平。
■在这项临床对照试验中,被诊断为胰岛素抵抗的妇女被随机分为两组。训练组(T)在五台重量和两台有氧器械上进行了结合力量(50%-80%1RM)和耐力(50%-75%HRR)运动的回路训练,33分钟,每周三次,三个月。对照组非训练组(NT)的妇女没有改变以前的体育锻炼。在研究开始和干预期之后,一个重复的最大值,体重,和组成,静息心率(HR),血压,葡萄糖,胰岛素,血脂,促甲状腺激素(TSH),胰岛素样生长因子-1(IGF-1),测量RBP4和胰岛素抵抗(HOMA-IR)。使用双向重复测量ANOVA分析了27例患者的结果。
■发现静息HR(p<0.010)和总瘦体重(p<0.039)的组间随时间变化的模式存在显着差异。HOMA-IR没有差异,与研究前相比,T组研究后观察到RBP4。发现RBP4与TSH浓度之间存在显着相关性。
■结合力量和耐力锻炼的十二周巡回训练对HOMA-IR的影响较小,葡萄糖和脂质代谢,IGF-1,TSH,RBP4。虽然中等强度的电路训练被认为是安全的,其在超重和轻度肥胖患者中的有效性可能不足以降低胰岛素抵抗。
■ClinicalTrials.gov:NCT04528693,注册于2020年8月23日。
UNASSIGNED: Circuit training is an exercise mode, that may include both endurance and resistance components. There are premises that a combination of these two modalities brings additional benefits, particularly in improving insulin sensitivity. The retinol-binding protein 4 (RBP4) may inhibit signaling from insulin metabolic pathways in skeletal muscles, thus developing insulin resistance. This study aimed to evaluate whether moderate intensity circuit training combining strength and endurance exercise induces changes in tissue insulin sensitivity, carbohydrate and lipid metabolism, and serum RBP4 levels in insulin-resistant women.
UNASSIGNED: In this clinical controlled trial women diagnosed with insulin-resistance were randomly divided into two groups. The training group (T) performed circuit training combining strength (50%-80%1RM) and endurance (50%-75%HRR) exercise on five weight and two cardio machines, for 33 minutes, three times per week, for 3 months. Women from the control non-training group (NT) did not change their previous physical activity. At the beginning of the study and after the intervention period, a one-repetition maximum, body mass, and composition, resting heart rate (HR), blood pressure, glucose, insulin, blood lipids, thyroid-stimulating hormone (TSH), insulin-like growth factor-1 (IGF-1), RBP4, and insulin resistance (HOMA-IR) were measured. The results of 27 patients were analyzed using a two-way repeated measures ANOVA.
UNASSIGNED: Significant differences in the pattern of change over time between the groups for resting HR (p < 0.010) and total lean mass (p < 0.039) were found. No differences in HOMA-IR, and RBP4 were observed post-study compared to pre-study in the T group. A significant correlation between RBP4 and TSH concentration was found.
UNASSIGNED: Twelve-week circuit training combining strength and endurance exercise has minor effects on HOMA-IR, glucose and lipid metabolism, IGF-1, TSH, and RBP4. Although moderate-intensity circuit training is considered safe, its effectiveness in patients with overweight and mild obesity may be insufficient to reduce insulin resistance.
UNASSIGNED: ClinicalTrials.gov: NCT04528693, registered August 23, 2020.