■确定与遗传性玻璃体视网膜病变相关的小儿视网膜脱离(RD)的治疗模式和结果。
■使用IRIS®Registry(IntelligentResearchinSight)数据库进行回顾性队列分析。
■患者<18岁,患有与玻璃体视网膜变性相关的流源性RD和系统性疾病(例如,Stickler综合征)或2013-2019年的其他玻璃体畸形。
■使用国际疾病分类确定病例,IRIS®Registry队列的第九次和第十次修订(ICD-9,ICD-10)诊断代码。通过文本搜索捕获未由特定ICD代码编码的其他遗传性玻璃体视网膜病变。还包括非特异性玻璃体异常ICD代码。排除标准包括使用ICD代码治疗眼外伤和浆液性或渗出性视网膜脱离的外伤性视网膜脱离。使用用于修复视网膜脱离的当前程序术语(CPT)代码鉴定外科手术。收集的基线人口统计信息包括年龄,性别,种族/民族,提供者位置的地理区域,和健康保险状况。
■本研究中测量的主要结果是首次手术的平均时间,出现双侧脱离的眼睛数量,以及初始外科手术的选择。
■共确定1722例患者的2115只眼(平均年龄,10.4岁;58%男性)。首次手术的中位时间为7天(四分位距,40天)。1134例患者的一千四百七只眼有≥1年的随访,506只眼睛(36%)发展为同眼RD。33%的患者出现双侧脱离,349只眼在CPT代码记录的索引日期后1年内进行了初次RD手术。初次表现后平均32天发生同眼脱离。1年内每只眼睛的平均手术次数为1.68。最佳矫正视力没有从基线20/54提高到20/62。最初的手术是最常见的复杂的RD修复(n=176),其次是巩膜扣(n=102),平坦部玻璃体切除术(n=89),激光(n=59),冷冻疗法(n=5),和气动视网膜固定术(n=5)。手术后1年内有51例新诊断青光眼和37例新诊断无晶状体眼。
■IRIS注册数据提供了对罕见的儿科玻璃体视网膜病变相关视网膜病变的洞察,有很高的再次手术率和同伴的眼睛参与。
■专有或商业披露可以在参考文献之后找到。
UNASSIGNED: To determine the treatment patterns and outcomes of pediatric retinal detachments (RDs) associated with hereditary vitreoretinopathies.
UNASSIGNED: Retrospective cohort analysis using IRIS® Registry (Intelligent Research in Sight) database.
UNASSIGNED: Patients < 18 years old with a rhegmatogenous RD and a systemic disorder associated with vitreoretinal degeneration (e.g., Stickler syndrome) or other malformation of the vitreous from 2013-2019.
UNASSIGNED: Cases were identified using International Classification of Diseases, Ninth and Tenth Revisions (ICD-9, ICD-10) diagnostic codes from the IRIS® Registry cohort. Other hereditary vitreoretinopathies that are not encoded by specific ICD code(s) were captured by text search. Nonspecific vitreous abnormality ICD codes were also included. Exclusion criteria included traumatic retinal detachments using ICD codes for ocular trauma and serous or exudative retinal detachment. Surgical procedures were identified using Current Procedural Terminology (CPT) codes for repair of retinal detachment. Baseline demographic information collected included age, gender, race/ethnicity, geographic region of the provider location, and health insurance status.
UNASSIGNED: Main outcomes measured in this study were average time to first surgery, number of eyes presenting with bilateral detachments, and choice of initial surgical procedure.
UNASSIGNED: A total of 2115 eyes of 1722 patients were identified (mean age, 10.4 years; 58% male). The median time to first surgery was 7 days (interquartile range, 40 days). One thousand four hundred seven eyes of 1134 patients had ≥ 1 year of follow-up, with 506 eyes (36%) developing a fellow eye RD. Thirty-three percent of patients presenting with bilateral detachments, and 349 eyes had initial RD surgery within 1 year of the index date documented by CPT code. Fellow eye detachment occurred a mean of 32 days after initial presentation. The mean number of surgeries per eye within 1 year was 1.68. Best-corrected visual acuity did not improve from a baseline 20/54 to 20/62. The initial procedure was most commonly complex RD repair (n = 176), followed by scleral buckle (n = 102), pars plana vitrectomy (n = 89), laser (n = 59), cryotherapy (n = 5), and pneumatic retinopexy (n = 5). There were 51 new diagnoses of glaucoma and 37 new diagnoses of aphakia within 1 year after the surgical procedure.
UNASSIGNED: IRIS Registry data provide insight into rare pediatric vitreoretinopathy-associated RDs, which have a high rate of reoperation and fellow eye involvement.
UNASSIGNED: Proprietary or commercial disclosure may be found after the references.