目的:女性在怀孕时更容易发生缺铁性贫血。尚未彻底研究平均网织红细胞体积(MRV)在识别怀孕期间ID贫血中的诊断用途。这项研究的目的是评估MRV诊断孕妇ID的有效性。
方法:首先,对20名健康女性志愿者(健康组)的MRV在1个月的特定日进行测量。随后,对724名孕妇的临床资料进行了全面检查.这些妇女分为两组:282例有ID(研究组)和442例无ID(对照组)。MRV等参数,网织红细胞血红蛋白当量(RHE),红细胞体积分布宽度-标准偏差(RDW-SD),平均红细胞体积(MCV),平均红细胞血红蛋白(MCH),平均红细胞血红蛋白浓度(MCHC),血细胞比容(HCT),网织红细胞计数(RET),MRV/MCV比值,并对血清铁蛋白(SF)进行分析比较。
结果:20名健康个体的MRV在一个月的时间内保持一致。此外,MRV有显著差异,RHE,RDW-SD,MCV,MCH,MCHC,HCT,RET,研究组与对照组之间的MRV/MCV。受试者工作特征(ROC)分析表明,这些措施的曲线下面积(AUC)分别为:0.840、0.837、0.676、0.654、0.639、0.602、0.571、0.550和0.816。最终,口服铁剂治疗前后MRV存在显著差异.
结论:在健康女性中,MRV保持稳定,是可靠的ID标记,可用于评估怀孕期间口服铁治疗的有效性。
OBJECTIVE: Women are more prone to iron deficiency (ID) anemia when pregnant. The diagnostic use of mean reticulocyte volume (MRV) in identifying ID anemia during pregnancy has not been thoroughly investigated. The objective of this study is to evaluate the effectiveness of MRV in diagnosing ID in pregnant women.
METHODS: Firstly, MRV of 20 healthy female volunteers (healthy group) was measured on specific days for one month. Subsequently, clinical data from 724 pregnant women were thoroughly examined. These women were divided into two groups: 282 with ID (research group) and 442 without ID (control group). Parameters such as MRV, reticulocyte hemoglobin equivalent (RHE), red blood cell volume distribution width-standard deviation (RDW-SD), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), hematocrit (HCT), reticulocyte count (RET), MRV/MCV ratio, and serum ferritin (SF) were analyzed and compared.
RESULTS: MRV remained consistent over a period of one month for 20 healthy individuals. In addition, there were significant differences in MRV, RHE, RDW-SD, MCV, MCH, MCHC, HCT, RET, and MRV/MCV between the research group and control group. The receiver operating characteristic (ROC) analysis showed that the areas under the curve (AUCs) for these measures were as follow: 0.840, 0.837, 0.676, 0.654, 0.639, 0.602, 0.571, 0.550, and 0.816, respectively. Ultimately, there was a substantial disparity in MRV prior to and following therapy with oral iron treatments.
CONCLUSIONS: In healthy women, MRV remains stable and is a reliable ID marker, which can be used to assess oral iron treatment effectiveness during pregnancy.