■早期的研究表明,在工作场所暴露于多氯二苯并对二恶英(PCDD)可以增加癌症相关死亡的可能性。然而,关于PCDD暴露与普通人群癌症死亡风险之间的联系的信息有限(即,未通过职业接触这些物质的个人)。
■国家健康和营养检查调查(NHANES)在普通人群中检测到PCDD,截至2019年12月31日,死亡数据最近更新。我们进行了Cox回归分析,并控制了包括年龄在内的协变量,性别,种族,教育程度,身体活动,酒精摄入量,NHANES调查期间,BMI类别,可替宁浓度,和家庭收入。
■在考虑了混杂因素后,研究结果表明,1,2,3,4,6,7,8,9-八氯二苯并对二恶英每增加1个对数单位,任何原因死亡的可能性增加了76%,p值为0.003。1,2,3,4,6,7,8-七氯二苯并呋喃浓度增加1个对数单位可能导致癌症死亡风险增加90%。P值为0.034,95%置信区间为0.05-2.43。随着1,2,3,4,6,7,8-七氯二苯并呋喃的浓度增加,剂量-反应曲线表明癌症死亡风险呈比例上升,伴随着0.044的线性p值。敏感性分析表明,我们的研究结果是有弹性的。
■在一般人群中,由于1,2,3,4,6,7,8-七氯二苯并呋喃的存在,PCDD的癌症死亡率风险升高.需要机理研究来进一步证实这一点。
Earlier research has indicated that being exposed to polychlorinated dibenzo-p-dioxins (PCDDs) in the workplace can heighten the likelihood of cancer-related deaths. Nevertheless, there is limited information available regarding the connection between PCDD exposure and the risk of cancer mortality in the general population (i.e., individuals not exposed to these substances through their occupation).
The National Health and Nutrition Examination Survey (NHANES) detected PCDDs in the general population, and the death data were recently updated as of December 31, 2019. We conducted Cox regression analysis and controlled for covariates including age, gender, ethnicity, educational attainment, physical activity, alcohol intake, NHANES survey period, BMI category, cotinine concentration, and household earnings.
After accounting for confounding factors, the findings indicated that for each incremental rise of 1 log unit in 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin, there was a 76% rise in the likelihood of death from any cause, with a p value of 0.003. An increase of 1 log unit in the concentration of 1,2,3,4,6,7,8-heptachlorodibenzofuran could potentially lead to a 90% higher risk of cancer mortality, as indicated by a p value of 0.034 and a 95% confidence interval of 0.05-2.43. As the concentrations of 1,2,3,4,6,7,8-heptachlorodibenzofuran increased, the dose-response curve indicated a proportional rise in the risk of cancer mortality, accompanied by a linear p value of 0.044. The sensitivity analysis demonstrated that our findings were resilient.
In the general population, an elevated risk of cancer mortality was observed in PCDDs due to the presence of 1,2,3,4,6,7,8-heptachlorodibenzofuran. Mechanistic research is required to further confirm it.