■确定新的修复材料(RenewalMI)中的哪些成分可以改善其在脱矿质牙本质内形成树脂标签的能力。
■各种成分包括聚赖氨酸(PLS),磷酸一钙(MCP),粉液比(PLR),4-甲基丙烯酰氧基乙基偏苯三酸酯酸酐(4META),和聚丙二醇二甲基丙烯酸酯(PPGDMA)。氨基甲酸酯二甲基丙烯酸酯(UDMA),含有PPGDMA(24重量%)和4META(3重量%),与具有MCP(8重量%)和PLS(5重量%)的玻璃填料混合。PLR为3:1或5:1。将MCP和/或PLS分别降低至4和2重量%或完全去除MCP,PLS,4META或PPGDMA总共提供16种制剂。续订MI,Z250(有或没有Scotchbond通用粘合剂)和Activa用作商业比较剂。胶原蛋白圆盘是通过完全去矿化2毫米厚,人类,前磨牙,冠状牙本质盘浸入甲酸(4M)48小时。然后将修复材料应用于顶部(n=3),在次氯酸钠(15%)中溶解胶原蛋白之前。SEM/EDX用于确定树脂标签长度,composition,和表面覆盖。
■标签>400、20和200µm,覆盖了续约MI的粘附界面的62、55和39%,Scotchbond和Activa,分别。用实验配方,它们的长度为200和>400µm,具有较高的vs.低PLR,主要由聚合单体组成。覆盖的粘合界面的百分比在35%和84%之间变化。减少PLS或MCP会导致覆盖率下降,这与它们的浓度呈线性关系。当PLS或PLR较低时,降低MCP的作用较小。4META的去除导致比PPGDMA去除更大的覆盖率降低。
■PLS,MCP,4META,PPGDMA和低PLR共同增强了RenewalMI标签的形成,从而密封,去矿化牙本质.
UNASSIGNED: To determine which components in a new restorative material (Renewal MI) improve its ability to form resin tags within demineralized dentine.
UNASSIGNED: Varied components included polylysine (PLS), monocalcium phosphate (MCP), powder to liquid ratio (PLR), 4-methacryloyloxyethyl trimellitate anhydride (4META), and polypropylene glycol dimethacrylate (PPGDMA). Urethane dimethacrylate (UDMA), containing PPGDMA (24 wt%) and 4META (3 wt%), was mixed with glass filler with MCP (8 wt%) and PLS (5 wt%). PLR was 3:1 or 5:1. Reducing MCP and/or PLS to 4 and 2 wt% respectively or fully removing MCP, PLS, 4META or PPGDMA gave 16 formulations in total. Renewal MI, Z250 (with or without Scotchbond Universal adhesive) and Activa were used as commercial comparators. Collagen discs were obtained by totally demineralizing 2 mm thick, human, premolar, coronal dentine discs by immersion in formic acid (4M) for 48 h. The restorative materials were then applied on top (n = 3), before dissolving the collagen in sodium hypochlorite (15%). SEM/EDX was employed to determine resin tags length, composition, and surface coverage.
UNASSIGNED: Tags were >400, 20 and 200 µm and covered 62, 55 and 39% of the adhesion interface for Renewal MI, Scotchbond and Activa, respectively. With experimental formulations, they were 200 and >400 µm long with high vs. low PLR and composed primarily of polymerized monomers. Percentages of the adhesion interface covered varied between 35 and 84%. Reducing PLS or MCP caused a decline in coverage that was linear with their concentrations. Reducing MCP had lesser effect when PLS or PLR were low. Removal of 4META caused a greater reduction in coverage than PPGDMA removal.
UNASSIGNED: PLS, MCP, 4META, PPGDMA and low PLR together enhance Renewal MI tags formation in, and thereby sealing of, demineralized dentine.