■良性阵发性位置性眩晕(BPPV)是临床常见的眩晕性疾病,这种疾病最有效的治疗方法是管道重新定位程序(CRP)。大多数患者在单一治疗后恢复正常。然而,部分患者治疗后仍有残留头晕(RD),目前该病的发病机制尚不清楚。目的利用静息态功能磁共振成像(rs-fMRI)探讨RD患者是否存在脑功能活动异常,为研究RD的发病机制提供影像学依据。
■徐州医科大学第二附属医院BPPV患者纳入时间为2021年12月至2022年11月。所有患者都接受了人口统计学和临床特征的收集(年龄,性别,涉及半规管,患侧,CRP次数,BPPV课程,RD症状的持续时间,他们是否有高血压,糖尿病,冠心病.),规模评估,包括头晕障碍库存(DHI),汉密尔顿焦虑量表(HAMA),汉密尔顿抑郁量表(HAMD),rs-fMRI数据收集,CRP治疗,然后进行一个月的随访.根据后续结果,包括18例RD患者。同时,我们从我们医院的体检中心选择了19名与他们年龄相匹配的健康个体,性别作为健康控制(HC)。首先,采用振幅低频波动(ALFF)分析方法比较两组受试者的局部功能活动。然后,提取具有不同ALFF结果的大脑区域作为种子点。采用基于种子点的功能连接(FC)分析方法探讨RD患者的全脑FC。最后,我们对临床特征和rs-fMRI数据进行了相关性分析.
■与HC相比,RD患者右前肌ALFF值较低,右上颞回(STG)ALFF值较高。当使用正确的STG作为种子点时,发现在正确的STG之间的FC,右颌上回(SMG),RD患者的左前肌减少。然而,当使用右前叶作为种子点时,在FC中未观察到明显的异常。
■在RD患者中,右前叶的局部功能活动减弱,右STG的局部功能活性增强。此外,正确的STG之间的FC,正确的SMG,而左前叶被削弱了.这些变化可以解释头晕的症状,漂浮的感觉,行走不稳定,颈部松紧度,其他症状在一定程度上与RD有关。
UNASSIGNED: Benign paroxysmal positional vertigo (BPPV) is a common clinical vertigo disease, and the most effective treatment for this disease is canal repositioning procedures (CRP). Most patients return to normal after a single treatment. However, some patients still experience residual dizziness (RD) after treatment, and this disease\'s pathogenesis is currently unclear. The purpose of this study is to explore whether there are abnormal brain functional activities in patients with RD by using resting-state functional magnetic resonance imaging (rs-fMRI) and to provide imaging evidence for the study of the pathogenesis of RD.
UNASSIGNED: The BPPV patients in the Second Affiliated Hospital of Xuzhou Medical University had been included from December 2021 to November 2022. All patients had been received the collection of demographic and clinical characteristics (age, gender, involved semicircular canal, affected side, CRP times, BPPV course, duration of RD symptoms, and whether they had hypertension, diabetes, coronary heart disease.), scale assessment, including Dizziness Handicap Inventory (DHI), Hamilton Anxiety Inventory (HAMA), Hamilton Depression Inventory (HAMD), rs-fMRI data collection, CRP treatment, and then a one-month follow-up. According to the follow-up results, 18 patients with RD were included. At the same time, we selected 19 healthy individuals from our hospital\'s physical examination center who matched their age, gender as health controls (HC). First, the amplitude of low-frequency fluctuations (ALFF) analysis method was used to compare the local functional activities of the two groups of subjects. Then, the brain regions with different ALFF results were extracted as seed points. Functional connectivity (FC) analysis method based on seed points was used to explore the whole brain FC of patients with RD. Finally, a correlation analysis between clinical features and rs-fMRI data was performed.
UNASSIGNED: Compared to the HC, patients with RD showed lower ALFF value in the right precuneus and higher ALFF value in the right superior temporal gyrus (STG). When using the right STG as a seed point, it was found that the FC between the right STG, the right supramarginal gyrus (SMG), and the left precuneus was decreased in RD patients. However, no significant abnormalities in the FC were observed when using the right precuneus as a seed point.
UNASSIGNED: In patients with RD, the local functional activity of the right precuneus is weakened, and the local functional activity of the right STG is enhanced. Furthermore, the FC between the right STG, the right SMG, and the left precuneus is weakened. These changes may explain the symptoms of dizziness, floating sensation, walking instability, neck tightness, and other symptoms in patients with RD to a certain extent.