■人类免疫缺陷病毒(HIV)阳性个体中的机会性感染(OIs)是由于HIV介导的免疫抑制而比正常人更频繁或更严重的感染。当这些OI在获得性免疫缺陷综合征(AIDS)患者中以复发或再感染的形式出现时,据说它们是OI的复发。这项研究将试图找出在解决研究领域的负担方面的差距。
这项横断面研究是在阿尔巴明奇镇一家公共卫生机构就诊的450名艾滋病毒/艾滋病患者中进行的,埃塞俄比亚南部。这项研究于2020年4月5日至2020年4月20日进行。使用计算机生成的简单随机抽样来选择研究参与者。使用SPSS版本25统计软件进行分析。使用双变量和多变量逻辑回归来确定与OIs复发相关的因素。P值≤0.05用于确定显著关联。结果以数字形式报告,tables,和图表,基于数据类型。
■450名研究参与者的平均±标准差年龄为34.3±8.47岁。80例患者(17.8%)患有慢性疾病。总的来说,119名HIV/AIDS患者(26.4%)被诊断为OI复发。肺结核是主要的复发OI。年龄,农村住宅,慢性疾病,基线抗逆转录病毒治疗(ART)依从性,目前的血红蛋白水平,和当前细胞分化4(CD4)计数是与复发显着相关的因素。
■尽管OIs的复发程度低于以前的研究,利益相关者之间必须继续努力,以解决与OI再次发生相关的因素。
UNASSIGNED: Opportunistic infections (OIs) in human immunodeficiency virus (HIV)-positive individuals are infections that are more frequent or more severe than normal because of HIV-mediated immunosuppression. When these OIs occur in acquired immune deficiency syndrome (AIDS) patients in the form of relapse or reinfection, they are said to be a
reoccurrence of OI. This study will try to identify gaps in addressing the burden in the study area.
UNASSIGNED: This cross-sectional study was conducted among 450 HIV/AIDS patients with previous OIs attending a public health facility in Arba Minch Town, Southern Ethiopia. This study was conducted from 5 April 2020 to 20 April 2020. Computer-generated simple random sampling was used to select the study participants. Analysis was performed using SPSS version 25 statistical software. Bivariate and multivariable logistic regression was used to identify factors associated with the
reoccurrence of OIs. A P value of ≤0.05 was used to determine significant association. The results were reported as numerical figures, tables, and diagrams, based on the type of data.
UNASSIGNED: The mean ± standard deviation age of the 450 study participants was 34.3±8.47 years. Eighty patients (17.8%) had chronic disease. In total, 119 HIV/AIDS patients (26.4%) were diagnosed with
reoccurrence of OIs. Pulmonary tuberculosis was the major reoccurring OI. Age, rural residence, chronic disease, baseline anti-retroviral therapy (ART) adherence, current hemoglobin level, and current cell differentiation-4 (CD4) count were factors significantly associated with reoccurrence.
UNASSIGNED: Although the magnitude of
reoccurrence of OIs was lower than in previous studies, efforts have to be continued among stakeholders to tackle factors associated with the
reoccurrence of OIs.