■多普勒超声检查参数,特别是电阻指数(RI),已被确定为评估肾移植功能障碍(RTD)的重要工具。然而,先前关于这一问题的研究结果存在一些歧义。因此,我们研究的目的是检验RTD后RI变化之间的关系.
■这是一项系统评价和荟萃分析研究。我们搜索了三个电子数据库PubMed,WebofScience,还有Scopus,从2000年到2022年5月10日。主要效应大小被认为是通过活检证实的RTD病例与无RTD的对照患者的平均RI差异。我们使用随机效应模型来汇集效应大小。
■我们的综述包括13项研究。对照组的合并平均值(95%CI)为0.71(0.67,0.75),肾移植功能障碍患者为0.73(0.68,0.78),在两种分析都具有高度异质性的随机效应模型下(I2=98%和97%,分别)。合并平均值在对照组和RTD患者之间存在显着差异(P=0.05)。基于合并效应大小的t检验。
■根据我们的研究结果,我们发现肾移植功能障碍患者的RI与对照组之间存在显着差异。然而,在RTD的治疗和诊断中,RI不能替代肾活检。
UNASSIGNED: Doppler sonography parameters, particularly the resistive index (RI), have been identified as an essential tool for assessing renal transplant dysfunction (RTD). However, there is some ambiguity in the findings of previous research studies on this matter. Therefore, the objective of our study is to examine the relationship between changes in RI subsequent to RTD.
UNASSIGNED: This was a systematic review and meta-analysis study. We searched three electronic databases PubMed, Web of Science, and Scopus, from the year 2000 to 10 May 2022. The main effect size was considered as the mean RI differences of cases with RTD confirmed by biopsy with control patients with no RTD. We used random effect models to pool the effect size.
UNASSIGNED: Thirteen studies were included in our review. The pooled mean (95% CI) for the control group was calculated to be 0.71 (0.67, 0.75) and for patients with renal transplant dysfunction was 0.73 (0.68, 0.78), under a random effect model with high heterogeneity for both analyses (I2=98% and 97%, respectively). The pooled mean was significantly different between the control group and patients with RTD (P= 0.05), based on a t-test of pooled effect sizes.
UNASSIGNED: Based on the result of our study, we showed that there is a significant difference between RI in patients with kidney transplant dysfunction and the control group. However, RI cannot substitute kidney biopsy in the management and diagnosis of RTD.