remission of hypertension

  • 文章类型: Journal Article
    在老龄化社会和越来越多的肥胖人群的时代,越来越多的老年患者正在咨询减肥外科医师。高血压(HT)的发病率也随着年龄和体重而上升,使老年人的治疗成为一个重大挑战。
    确定65岁以上患者减重手术后HT缓解的预测因素。
    一项回顾性研究分析了2008年至2022年在波兰接受腹腔镜减肥手术的65岁以上HT患者。数据来自11个减肥中心。患者分为两组:反应者(R)和非反应者(NR)。进行多因素logistic回归分析以确定显著的独立危险因素。
    该研究分析了244名患者,55例(22.5%)患者的HT完全缓解。几乎90%的患者显示HT改善。平均随访时间为47.4个月。导致HT缓解的因素包括HT持续时间少于5年,使用单一药物,与%EWL有显著相关性。
    65岁以上患者的减重手术对HT缓解有积极作用。HT缓解的机会随着药物的减少而增加,较短的HT持续时间,手术后体重减轻更大。
    UNASSIGNED: In the era of an aging society and a growing number of obese people, an increasing number of older patients are consulting bariatric surgeons. The incidence of hypertension (HT) also rises with age and body weight, making the treatment of the elderly a significant challenge.
    UNASSIGNED: To identify predictors of HT remission after bariatric surgery in patients over 65 years of age.
    UNASSIGNED: A retrospective study analyzed patients over 65 years old with HT who underwent laparoscopic bariatric procedures in Poland between 2008 and 2022. The data came from 11 bariatric centers. Patients were categorized into two groups: responders (R) and non-responders (NR). A multivariate logistic regression analysis was conducted to identify significant independent risk factors.
    UNASSIGNED: The study analyzed 244 patients, with complete HT remission observed in 55 (22.5%) patients. Almost 90% of patients showed improvement in HT. The mean follow-up time was 47.4 months. Factors contributing to HT remission included HT duration of less than 5 years, the use of single medication, and a significant correlation with %EWL.
    UNASSIGNED: Bariatric surgery in patients aged over 65 has a positive effect on HT remission. The chance of HT remission increases with fewer medications, shorter HT duration, and greater weight loss after surgery.
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  • 文章类型: Journal Article
    目的:根据现行指南,建议进行适度至剧烈的体育锻炼以预防高血压。然而,总体力活动(TPA)及其变化对正常高血压患者和高血压患者有益的程度尚不确定。我们的目的是研究TPA及其变化对发病率的影响,programming,以及大规模前瞻性队列中高血压的缓解。
    方法:共有73,077名参与者(55,101名正常高血压患者和17,976名高血压患者)符合TPA分析的条件。在平均7.16年(394,038人年)的随访期间,确定了12,211例高血压病例。TPA被估计为代谢当量并被分类为四分位数。使用Cox比例风险回归和多变量逻辑回归来估计TPA和TPA变化与高血压事件和高血压进展/缓解的关联。
    结果:与TPA的最低四分位数相比,第三和最高四分位数的Normotensives降低了高血压事件的风险,风险比(HR)为0.86[95%置信区间(CI):0.81-0.91]和0.81(95%CI:0.77-0.86),分别。TPA最高四分位数的高血压患者显示高血压进展风险降低[比值比(OR)=0.87,95%CI:0.79-0.95],高血压缓解概率增加(OR=1.17,95%CI:1.05~1.29)。此外,在随访期间,从久坐的生活方式中积极运动可以降低25%(HR=0.75,95%CI:0.58-0.96)的高血压事件风险,而那些久坐不动的人并没有从最初的活动中获益。
    结论:我们的研究结果表明,增加和维持TPA水平可能有益于正常人群,而需要更高的TPA水平来有效控制进展和改善高血压的缓解。体力活动无疑在高血压的一级和二级预防中起着至关重要的作用。
    OBJECTIVE: Moderate to vigorous physical activity is recommended to prevent hypertension according to the current guidelines. However, the degree to which the total physical activity (TPA) and its changes benefit normotensives and hypertensives is uncertain. We aimed to examine the effects of TPA and its changes on the incidence, progression, and remission of hypertension in the large-scale prospective cohorts.
    METHODS: A total of 73,077 participants (55,101 normotensives and 17,976 hypertensives) were eligible for TPA analyses. During a mean follow-up of 7.16 years (394,038 person-years), 12,211 hypertension cases were identified. TPA was estimated as metabolic equivalents and categorized into quartiles. Cox proportional hazards regression and multivariable logistic regression were used to estimate associations of TPA and changes in TPA with incident hypertension and progression/remission of hypertension.
    RESULTS: Compared with the lowest quartile of TPA, normotensives at the third and the highest quartile had a decreased risk of incident hypertension, with hazard ratios (HRs) of 0.86 [95% confidence interval (CI): 0.81-0.91] and 0.81 (95% CI: 0.77-0.86), respectively. Hypertensives at the highest quartile of TPA demonstrated a decreased risk of progression of hypertension [odds ratio (OR) = 0.87, 95% CI: 0.79-0.95], and an increased probability of hypertension remission (OR = 1.17, 95% CI: 1.05-1.29). Moreover, getting active from a sedentary lifestyle during the follow-up period could reduce 25% (HR = 0.75, 95% CI: 0.58-0.96) risk of incident hypertension, whereas those becoming sedentary did not achieve benefit from initially being active.
    CONCLUSIONS: Our findings indicated that increasing and maintaining TPA levels could benefit normotensives, whereas higher TPA levels were needed to effectively control progression and improve remission of hypertension. Physical activity played undoubtedly an essential role in both primary and secondary prevention of hypertension.
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