■本研究探讨了不同剂量的甲苯磺酸瑞咪唑安定(RT)和异丙酚复合瑞芬太尼麻醉对腹腔镜手术患者血流动力学和炎症反应的影响。
■90名BMI小于35kg/m²的患者,归类为ASAII-III,并计划进行腹腔镜手术,参加了这项研究。患者分为三组:低剂量RT组(A),高剂量RT组(B),丙泊酚组(C)。SBP等血液动力学指标的变化,DBP,HR,MAP,和炎症反应指标,如IL-6,SAA,CRP,PCT,随着拔管时间和舒芬太尼的剂量,瑞芬太尼,乌拉地尔,和去氧肾上腺素,在三组之间进行比较。
■拔管时间差异无统计学意义,舒芬太尼和瑞芬太尼的剂量,或三组之间乌拉地尔和去氧肾上腺素的使用率和平均剂量。A组去氧肾上腺素平均剂量低于B组和C组,具有统计学上的显著差异。SBP组间差异无统计学意义,DBP,HR,和MAP从T0到T2,也不在IL-6,SAA,CRP,或PCT水平。
■在腹腔镜手术中使用RT诱导和维持麻醉可确保患者稳定的血流动力学和炎症反应。低剂量RT可降低术中去氧肾上腺素等血管加压药的使用率和剂量。
UNASSIGNED: This study explored the effects of different doses of remimazolam tosilate (RT) and propofol combined with remifentanil anesthesia on hemodynamic and inflammatory responses in patients undergoing laparoscopic surgery.
UNASSIGNED: Ninety patients with a BMI of less than 35 kg/m², classified as ASA II-III and scheduled for laparoscopic surgery, were enrolled in this study. Patients were divided into three groups: low-dose RT group (A), high-dose RT group (B), and propofol group (C). The changes in hemodynamic indices such as SBP, DBP, HR, MAP, and inflammatory response indices such as IL-6, SAA, CRP, and PCT, along with extubation time and doses of sufentanil, remifentanil, urapidil, and phenylephrine, were compared among the three groups.
UNASSIGNED: There were no statistically significant differences in extubation time, doses of sufentanil and remifentanil, or the usage rates and average doses of urapidil and phenylephrine between the three groups. The average dose of phenylephrine in group A was lower than in group B and group C, with a statistically significant difference. There were no statistically significant differences among the groups in SBP, DBP, HR, and MAP from T0 to T2, nor in IL-6, SAA, CRP, or PCT levels.
UNASSIGNED: Using RT for induction and maintenance of anesthesia in laparoscopic surgery ensures stable hemodynamic and inflammatory responses in patients. Low-dose RT may reduce the usage rate and dose of vasopressors such as phenylephrine during surgery.