■为了研究定量纵向弛豫时间(T1)的值,横向弛豫时间(T2),和来自合成磁共振成像(MRI)的质子密度(PD)图,用于评估无淋巴结转移(LNM)的宫颈鳞状细胞癌(CSCC)中淋巴管间隙侵犯(LVSI)的状态。
■收集2020年5月至2023年3月在我院就诊的疑似宫颈癌患者。所有患者术前均行MRI检查,包括常规序列和合成MRI。本研究包括经病理证实无淋巴结转移的CSCC患者。根据LVSI的状态将受试者分为阴性和阳性LVSI组。使用独立样本t检验比较两组之间来自合成MRI的T1,T2和PD值的定量参数。接收器工作特性曲线用于确定参数的诊断功效。
■59例患者纳入本研究,分为阳性(n=32)和阴性LVSI组(n=27)。T1和T2值显示出负LVSI与正LVSICSCC之间的显着差异(1307.39±122.02与1193.03±107.86,P<0.0001;88.42±7.24vs.分别为80.99±5.50,P<0.0001)。T1,T2值以及T1和T2值的组合的曲线下面积(AUC)分别为0.756,0.799,0.834,各参数单独诊断和联合诊断的诊断效能差异无统计学意义。
■从合成MRI得出的定量参数可用于评估没有LNM的CSCC患者的LVSI状态。
UNASSIGNED: To investigate the value of quantitative longitudinal relaxation time (T1), transverse relaxation time (T2), and proton density (PD) maps derived from synthetic magnetic resonance imaging (MRI) for evaluating the status of lymphovascular space invasion (LVSI) in cervical squamous cell carcinoma (CSCC) without lymph node metastasis (LNM).
UNASSIGNED: Patients with suspected cervical cancer who visited our hospital from May 2020 to March 2023 were collected. All patients underwent preoperative MRI, including routine sequences and synthetic MRI. Patients with pathologically confirmed CSCC without lymphatic metastasis were included in this study. The subjects were divided into negative- and positive-LVSI groups based on the status of LVSI. Quantitative parameters of T1, T2, and PD values derived from synthetic MRI were compared between the two groups using independent samples t-test. Receiver operating characteristic curves were used to determine the diagnostic efficacy of the parameters.
UNASSIGNED: 59 patients were enrolled in this study and were classified as positive (n = 32) and negative LVSI groups (n = 27). T1 and T2 values showed significant differences in differentiating negative-LVSI from positive-LVSI CSCC (1307.39 ± 122.02 vs. 1193.03 ± 107.86, P<0.0001; 88.42 ± 7.24 vs. 80.99 ± 5.50, P<0.0001, respectively). The area under the curve (AUC) for T1, T2 values and a combination of T1 and T2 values were 0.756, 0.799, 0.834 respectively, and there is no statistically significant difference in the diagnostic efficacy between individual and combined diagnosis of each parameter.
UNASSIGNED: Quantitative parameters derived from synthetic MRI can be used to evaluate the LVSI status in patients with CSCC without LNM.