糖尿病是一种常见的慢性代谢性疾病,发病率逐年上升。糖尿病患者主要死于各种并发症,最常见的是糖尿病性心肌病。然而,糖尿病心肌病在临床上的检出率较低,缺乏针对性的治疗。最近,大量研究证实,糖尿病性心肌病的心肌细胞死亡涉及细胞焦凋亡,凋亡,坏死,铁性凋亡,坏死,突起,细胞埋葬,和其他过程。最重要的是,许多动物研究表明,糖尿病性心肌病的发生和进展可以通过抑制这些调节性细胞死亡过程来缓解,例如通过使用抑制剂,螯合剂,或基因操纵。因此,我们回顾了铁死亡的作用,坏死,和角化,糖尿病心肌病中三种新形式的细胞死亡,寻找可能的目标,并分析这些靶点的相应治疗方法。
Diabetes is a common chronic metabolic disease, and its incidence continues to increase year after year. Diabetic patients mainly die from various complications, with the most common being diabetic cardiomyopathy. However, the detection rate of diabetic cardiomyopathy is low in clinical practice, and targeted treatment is lacking. Recently, a large number of studies have confirmed that myocardial cell death in diabetic cardiomyopathy involves pyroptosis, apoptosis, necrosis, ferroptosis, necroptosis, cuproptosis, cellular burial, and other processes. Most importantly, numerous animal studies have shown that the onset and progression of diabetic cardiomyopathy can be mitigated by inhibiting these regulatory cell death processes, such as by utilizing inhibitors, chelators, or genetic manipulation. Therefore, we review the role of ferroptosis, necroptosis, and cuproptosis, three novel forms of cell death in diabetic cardiomyopathy, searching for possible targets, and analyzing the corresponding therapeutic approaches to these targets.