评估最初在青春期女性中检测到的HPV16是否可以在成年期重新检测到。
对27名青春期已知HPV16检测的成年女性的便利样本进行HPV16再检测评估。对一些原始和重新检测的HPV16分离株进行长控制区(LCR)DNA序列的比较。
再入学时的中位年龄为27.5岁(四分位距为26.7-29.6)。在最初的HPV16检测后平均六年重新登记。27名女性中有11人重新检测到HPV16。这些HPV16感染中的一些显然在青春期已经清除。LCR测序在来自6名女性的配对分离株中成功;在6例中的5例中,重新检测到的HPV16分离株与青春期检测到的相同,结论:HPV16可能在年轻女性中被特殊地检测到,即使在很长一段时间内。具有相同LCR序列的HPV16重新检测表明低水平持续感染,而不是真正的清除。尽管不能排除新获得的相同HPV16分离株的感染。然而,这项研究表明,在临床环境中,新的HPV16阳性检测可能不提示新的感染.
To assess whether HPV 16 originally detected in adolescent women can be redetected in adulthood.
A convenience sample of 27 adult women with known HPV 16 detection during adolescence was assessed for HPV 16
redetection. A comparison of the long control region (LCR) DNA sequences was performed on some of the original and redetected HPV 16 isolates.
Median age at reenrollment was 27.5 years (interquartile range of 26.7-29.6). Reenrollment occurred six years on average after the original HPV 16 detection. Eleven of 27 women had HPV 16 redetected. Some of these HPV 16 infections had apparently cleared during adolescence. LCR sequencing was successful in paired isolates from 6 women; in 5 of 6 cases the redetected HPV 16 isolates were identical to those detected during adolescence, CONCLUSIONS: HPV 16 may be episodically detected in young women, even over long time periods. HPV 16
redetection with identical LCR sequences suggests low-level persistent infection rather than true clearance, although newly acquired infection with an identical HPV 16 isolate cannot be excluded. However, this study suggests that a new HPV 16-positive test in a clinical setting may not indicate a new infection.