背景:产生的每个单位的红细胞(RBC)对医疗保健系统来说都是巨大的成本。应尽量减少不必要的血液浪费。在临床环境中,从血库的受保护设置发行后对血液成分袋的更改包括笔标记,那些暴露在感染环境中的人需要表面消毒。由于对RBC质量的影响不清楚,这些单位可能会被丢弃。在这项研究中,我们调查笔标记或表面消毒是否会对包装的红细胞质量产生负面影响,以及笔墨水是否会通过血袋扩散。
方法:用笔标记RBC袋(水,油,或以酒精为基础的)或进行表面消毒(乙醇,过氧化氢[优先湿巾],或基于苯扎氯铵的湿巾[CaviWipes]),并在施加处理后24小时和收集后第42天取样(每种情况下n=3)。分析样品的RBC体外质量标志物。使用质谱法(n=2)研究RBC袋中任何墨水的存在。
结果:来自24小时和第42天时间点的数据表明RBC计数没有差异,平均红细胞体积,形态学,可变形性,钾含量,或与未处理的对照相比,笔标记或消毒剂的溶血(p>.05)。在袋子内没有检测到墨水的痕迹。
结论:RBC单位标有圆点,凝胶,或者Sharpie笔不会遭受体外质量的损失,用70%乙醇进行表面消毒的红细胞单位也没有,先发制人的湿巾或CaviWipes。
Each unit of red blood cells (RBCs) produced represents a significant cost to the healthcare system. Unnecessary blood wastage should be minimized. In clinical settings, alterations to blood component bags after issue from the protected setting of the blood bank include pen markings, and those that are exposed to an infectious environment require surface disinfecting. These units may be discarded due to unclear effects on RBC quality. In this study, we investigate whether pen markings or surface disinfection negatively affects the quality of packed RBCs and whether pen ink diffuses through the blood bag.
RBC bags were marked with pens (water, oil, or alcohol-based) or subjected to surface disinfection (ethanol, hydrogen peroxide [Preempt wipes], or benzalkonium chloride-based wipes [CaviWipes]) and sampled 24 h after applying the treatment and at day 42 post collection (n = 3 for each condition). The samples were analyzed for RBC in vitro quality markers. The presence of any ink in the RBC bags was investigated using mass spectrometry (n = 2).
Data from 24 h and day 42 time points indicated no differences in RBC count, mean corpuscular volume, morphology, deformability, potassium content, or hemolysis for either pen markings or disinfectants when compared with their untreated controls (p > .05). No trace of ink was detected inside the bag.
RBC units marked with ballpoint, gel, or Sharpie pens do not suffer a loss of in vitro quality, nor do RBC units which have been surface disinfected with 70% ethanol, Preempt wipes or CaviWipes.