背景:该研究旨在探讨国家眼科研究所视觉功能问卷(NEIVFQ)的心理测量特性以及隐性Stargardt病(STGD1)中视力障碍(IVI)特征的影响。
方法:将NEIVFQ-25和IVI-28给予STGD1患者。根据心理上建立的NEIVFQ(视觉功能[VF]子量表;社会情感[SE]子量表)和IVI(功能[F]子量表;情感[E]子量表)的维度结构进行了分析。我们分析了内部一致性,维度,项目适合,和差分项功能(DIF),使用潜在特征模型。使用皮尔逊相关系数评估标准有效性。
结果:71名参与者(42名女性,29名男性;平均年龄,包括44±19年)。自我报告的难度水平低于两种工具中项目的平均难度。仪器的人员可靠性和人员分离指数分别为0.85和2.40(NEIVFQ-VF),0.69和1.49(NEI-VFQ-SE),0.88和2.77(IVI-F),和0.72和1.62(IVI-E)。没有项目显示出在使测量系统失真的水平不匹配。一个IVI项目按性别显示了DIF,但由于个人措施在很大程度上不受删除的影响而保留。NEIVFQ-VF和IVI-F以及NEIVFQ-SE和IVI-E呈正相关(r分别为0.79和0.64)。
结论:NEIVFQ和IVI在STGD1中具有可接受的心理测量特性,而IVI允许更敏感的人分层。通过包括特定于该疾病的其他内容域,可以改善针对STGD1个体的问卷调查。
BACKGROUND: The study aimed to explore the psychometric properties of the National Eye Institute Visual Function Questionnaire (NEI VFQ) and Impact of Vision Impairment (IVI) profile in recessive Stargardt disease (STGD1).
METHODS: The NEI VFQ-25 and IVI-28 were administered to individuals with STGD1. Responses were analyzed following psychometrically established dimension structures of the NEI VFQ (visual function [VF] subscale; socioemotional [SE] subscale) and of the IVI (functional [F] subscale; emotional [E] subscale). We analyzed internal consistency, dimensionality, item fit, and differential item functioning (DIF), using latent trait models. Criterion validity was assessed using Pearson correlation coefficients.
RESULTS: Seventy-one participants (42 females, 29 males; mean age, 44 ± 19 years) were included. Self-reported difficulty levels were lower than the mean difficulty of items in both instruments. Person reliability and person separation index of the instruments were 0.85 and 2.40 (NEI VFQ-VF), 0.69 and 1.49 (NEI-VFQ-SE), 0.88 and 2.77 (IVI-F), and 0.72 and 1.62 (IVI-E). No items showed misfit at a level distorting the measurement system. One IVI item showed DIF by gender but was retained as person measures were largely unaffected by its removal. NEI VFQ-VF and IVI-F as well as NEI VFQ-SE and IVI-E were positively correlated (r = 0.79 and 0.64, respectively).
CONCLUSIONS: The NEI VFQ and IVI have acceptable psychometric properties in STGD1 with the IVI allowing more sensitive person stratification. Targeting of questionnaires to individuals with STGD1 might be improved by including additional content domains specific to the disease.