瞄准同种异体移植物,自体移植物,异体和异种移植物经常用于牙周再生。这项研究的目的是确定晚期富血小板纤维蛋白(A-PRF)与脱矿质冻干同种异体骨移植(DFDBA)和单独的DFDBA在牙周缺陷中的疗效。方法这是一项裂口设计研究,其中包括10例患者中的20种次生缺陷。将患者随机分为两组,其中DFDBA同种异体移植物和A-PRF用于测试组,而对照组仅使用DFDBA同种异体移植物。此外,在基线时评估结果,三,九个月,分别,在临床和影像学参数方面。在P<0.05(统计学显著)的显著性水平下,用未配对t检验分析数据。结果两种治疗均显示从基线到9个月的临床和影像学参数降低。菌斑指数(PI)无显著差异,探查出血(BOP),临床依恋水平(CAL),和射线照相缺陷填充(RDF)。与对照组相比(3.40±0.516),试验组9个月时的探查袋深度(PPD)(3.22±0.422)具有统计学显著性,显示PPD降低(P=0.042).结论在其局限性内,研究表明,A-PRF加DFDBA和DFDBA单独治疗方式降低了基线的临床和影像学参数,9个月;然而,当比较两组时,A-PRF的纳入并没有显著改善治疗结果,除了九个月后的探测口袋深度。
Aim Allografts, autografts, alloplast and xenografts are frequently used for periodontal regeneration. The aim of this study was to determine the efficacy of advanced platelet-rich fibrin (A-PRF) in combination with demineralized freeze-dried bone allograft (DFDBA) and DFDBA alone in periodontal infrabony defects. Methodology This was a split-mouth design study where 20 infrabony defects in 10 patients were included. Patients were randomly divided into two groups, where DFDBA allograft and A-PRF were used in the test group, while the DFDBA allograft alone was used in the control group. Furthermore, the results were evaluated at baseline, three, and nine months, respectively, in terms of clinical and
radiographic parameters. Data were analysed with an unpaired t-test at the significance level of P < 0.05 (statistically significant). Results Both treatments showed reduced clinical and
radiographic parameters from baseline to nine months. There was a non-significant difference in the plaque index (PI), bleeding on probing (BOP), clinical attachment level (CAL), and
radiographic defect fill (RDF). In comparison to the control group (3.40 ± 0.516), the probing pocket depth (PPD) in the test group at nine months (3.22 ± 0.422) was statistically significant showing reduction in the PPD (P = 0.042). Conclusion Within its limitations, the study showed that A-PRF plus DFDBA and DFDBA alone treatment modalities reduced clinical and
radiographic parameters from baseline, at 9 months; however, the inclusion of A-PRF did not substantially improve the treatment outcome when comparing both the groups, except for the probing pocket depth after nine months.