目的:建立健康白种人桡骨乳头周围毛细血管丛(RPC)血管密度(VD)的规范数据库。
方法:633名健康白种人受试者接受了完整的眼科检查,包括裂隙灯生物显微镜,最佳矫正视力测量与早期治疗糖尿病视网膜病变研究图表,眼内压测量,眼底检查,和黄斑和视神经乳头(ONH)结构光学相干断层扫描(OCT)。记录RPC丛的正面4.5×4.5mmOCT血管造影扫描,并记录VD值,由AngioAnalytics™软件自动提供,noted.我们使用线性混合模型对年龄和性别对RPCVD值的影响进行了统计估计。
结果:560名受试者完全符合纳入标准,根据年龄,分为5组:18-50岁(77岁),51-60岁(160)61-70年(110年),71-80岁(132)≥81岁(81岁)。总的来说,整个人脸图像的平均RPCVD为53.03±4.27%。年龄与整个人脸图像的RPCVD值显着相关(r=-0.454;p<0.0001),随着年龄的增长而减少。线性混合模型公开了年龄对整个面部图像中的RPCVD值具有统计上显著的影响(p=0.0006)。随着年龄的增长,RPCVD值每年减少0.12。相反,在分析所有年龄组的整个面部图像和每个乳头旁象限的RPCVD值方面,没有发现显著的性别相关差异.
结论:结果显示,健康白种人受试者的RPCVD值随着年龄的增长而降低。这些数据可用于创建对临床使用有用的参考规范数据库。
结论:什么是已知的径向乳头状周围毛细血管(RPC)丛,由长的平行毛细血管组成,具有罕见的分叉和吻合,并沿着视网膜神经纤维层的路线一直延伸到后极,在一些视神经乳头(ONH)和视网膜疾病的早期可能会受到影响。这项研究报告了RPC血管密度(VD)值,在光学相干断层扫描血管造影上自动测量,在健康的白人受试者中,证明年龄与RPCVD值呈负相关。结果表明,健康白种人受试者的RPCVD值随着年龄的增长而降低。这些数据可用于创建对临床使用有用的参考规范数据库。
OBJECTIVE: To establish a normative database for vascular density (VD) of radial peripapillary capillary plexus (RPC) in healthy Caucasian subjects.
METHODS: 633 healthy Caucasian subjects underwent a complete ophthalmological examination, including slit-lamp biomicroscopy, best corrected visual acuity measurement with Early Treatment Diabetic Retinopathy Study charts, intraocular pressure measurement, fundus examination, and macular and optic nerve head (ONH) structural optical coherence tomography (OCT). En-face 4.5 × 4.5 mm OCT angiography scans of the RPC plexus were recorded and VD values, automatically provided by the AngioAnalytics™ software, noted. We statistically estimated the impact of age and gender on RPC VD values using a linear mixed model.
RESULTS: 560 subjects fully met inclusion criteria and, according to age, were stratified into 5 groups: 18-50 years (77), 51-60 years (160), 61-70 years (110), 71-80 years (132), and ≥ 81 years (81). Overall, mean RPC VD of the whole en-face image was 53.03 ± 4.27%. Age was significantly related to RPC VD values of whole en-face image (r = -0.454; p < 0.0001), which decreased with aging. The linear mixed model disclosed that age has a statistically significant effect on RPC VD values in whole en-face image (p = 0.0006). As age increases, RPC VD values decrease by 0.12 per year. Conversely, no significant gender-related differences were found in terms of RPC VD values of whole en-face image and each parapapillary quadrant analyzing all age group.
CONCLUSIONS: Results show that RPC VD values in healthy Caucasian subjects decrease with aging. These data may be used to create a reference normative database useful for clinical use.
CONCLUSIONS: What is known Radial peripapillary capillary (RPC) plexus, consisting of long parallel capillaries with rare bifurcations and anastomosis and extending straight along the course of the retinal nerve fiber layer to the posterior pole, may be affected early in some optic nerve head (ONH) and retinal diseases. What is new This study reports RPC vascular density (VD) values, automatically measured on optical coherence tomography angiography, in healthy Caucasian subjects, demonstrating that age is negatively related to RPC VD values. Results show that RPC VD values in healthy Caucasian subjects decrease with aging. These data may be used to create a reference normative database useful for clinical use.