细胞衰老,传统上被认为是增殖和生长的细胞被广泛的压力和损伤淹没的结果,长期以来一直被认为是一种关键的细胞衰老机制。最近的研究,然而,揭示了一种新的途径,称为“静止起源衰老”,细胞从静止状态直接过渡到衰老,绕过细胞增殖和生长。本文提出了一个框架,将静止和衰老之间的连续体概念化,并将静止加深作为衰老进入的前兆。我们探索这一过程的触发因素和控制因素,并讨论其生物学意义。鉴于人体中的大多数细胞是休眠的而不是增殖的,理解静止起源衰老对组织稳态有重要意义,老化,癌症,和各种疾病过程。探索这种以前被忽视的衰老细胞群的新范式可能会重塑我们对年龄相关疾病和组织再生的干预策略。
Cellular senescence, traditionally viewed as a consequence of proliferating and growing cells overwhelmed by extensive stresses and damage, has long been recognized as a critical cellular aging mechanism. Recent research, however, has revealed a novel pathway termed \"
quiescence-origin senescence\", where cells directly transition into senescence from the quiescent state, bypassing cell proliferation and growth. This opinion paper presents a framework conceptualizing a continuum between
quiescence and senescence with
quiescence deepening as a precursor to senescence entry. We explore the triggers and controllers of this process and discuss its biological implications. Given that the majority of cells in the human body are dormant rather than proliferative, understanding
quiescence-origin senescence has significant implications for tissue homeostasis, aging, cancer, and various disease processes. The new paradigm in exploring this previously overlooked senescent cell population may reshape our intervention strategies for age-related diseases and tissue regeneration.