介绍急性心肌梗塞(AMI)经常发生心律失常,这仍然是AMI中突然死亡的主要原因。镁水平异常与心律失常的出现有关,因为它可以增强心肌代谢和心输出量,并通过降低心律失常来防止钙积聚和心肌细胞死亡。这项研究的目的是评估血清镁水平和QTc间期作为AMI患者住院48小时的预后指标,并将这些参数与全球急性冠状动脉事件注册(GRACE)评分相关联。我们将AMI患者分为两组:血清镁水平异常的患者和正常的患者。方法获得伦理批准后,患者接受了详细的病史,其中包括社会人口统计细节,药物史,临床检查,和研究,如肌酸激酶心肌带(CK-MB),CK-total,肌钙蛋白T,心电图(QTc间期),二维超声心动图(2D-ECHO),血清肌酐和镁水平,心率,还有血压.我们还计算了所有患者的GRACE评分。结果我们发现,51-60岁年龄组的患者更容易发生心律失常,虽然AMI在男性中更为普遍,女性AMI患者心律失常的发生率略高。前壁运动异常(AWMA)是最主要的异常,12.3%的AWMA患者有心律失常。发生心律失常的患者的QTc间期明显更长。有趣的是,在QTc延长的患者中,35%的患者镁水平异常,而65%的人镁水平正常。在我们的研究中,在25例高镁血症患者中,9人(36%)发生了心律失常,而在75例低镁血症患者中,15例(20%)患者出现心律失常。有趣的是,我们发现GRACE评分与血清镁和QTc间期延长呈正相关。最后,在报告的六人死亡中,3例(50%)患者出现心律失常.结论总体来说,我们得出的结论是,血清镁水平作为心律失常的预后工具发挥着关键作用,并且在AMI患者入院48小时内是一项有用的研究.
Introduction Acute myocardial infarction (AMI) is frequently preceded by arrhythmias, which continue to be a prominent cause of abrupt fatality in AMI. Abnormal magnesium levels have been linked to the emergence of arrhythmia because it enhances myocardial metabolism and cardiac output and prevents calcium buildup and myocardial cell death by lowering arrhythmias. The objectives of this study were to evaluate serum magnesium levels and QTc interval as prognostic indicators in AMI patients during the initial 48 hours of hospital stay and to correlate these parameters with the Global Registry of Acute Coronary Events (GRACE) scoring. We studied AMI patients by dividing them into two groups: those with abnormal and those with normal serum magnesium levels. Methods After obtaining ethical approvals, patients were subjected to detailed history, which included sociodemographic details, drug history, clinical examination, and investigations such as creatine kinase myocardial band (CK-MB), CK-total, troponin-T, ECG (QTc interval), two-dimensional echocardiogram (2D-ECHO), serum creatinine and magnesium levels, heart rate, and blood pressure. We also calculated the GRACE score for all patients. Results We found that patients in the age group of 51-60 years were more prone to developing arrhythmias, and while AMI was more prevalent in males, the occurrence of arrhythmias was slightly higher in females with AMI. Anterior wall motion abnormality (AWMA) was the most predominant abnormality, and 12.3% of AWMA patients had arrhythmias. QTc interval was significantly longer in patients who developed arrhythmias. Interestingly, among patients with QTc prolongation, 35% patients had abnormal magnesium levels, while 65% had normal magnesium levels. In our study, of the 25 patients with hypermagnesemia, nine (36%) developed arrhythmias, while of the 75 patients with hypomagnesemia, 15 (20%) patients developed arrhythmias. Interestingly, we found that there was a positive correlation between GRACE score and serum magnesium as well as QTc interval prolongation. Lastly, among the six deaths reported, three (50%) patients had arrhythmias. Conclusion Overall, we conclude that serum magnesium levels play a pivotal role as a prognostic tool for arrhythmias and are a useful investigation during the initial 48 hours of admission in AMI patients.