未经评估:该研究旨在评估组织病理学变化,酶改变,全身γ射线照射对大鼠肺DNA的损伤以及碧萝精的保护作用。
UnASSIGNED:将100只成年雄性大鼠平均分为10组,包括对照组,四种抗氧化剂,γ-辐照,四种抗氧化剂+γ辐照。该研究在放射治疗前一天开始并持续3天。用5%二甲基亚砜溶解并通过胃管以37.5mg/kg的剂量给药,75mg/kg,150mg/kg,和300毫克/千克在24、48和72小时照射前。在一个部分中以900cGy的全身照射剂量进行照射。DNA损伤,组织病理学变化,过氧化氢酶(CAT),照射后3天,观察大鼠肺组织超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平。
UNASSIGNED:照射组CAT和SOD活性显著低于对照组(P<0.001)。抗氧化剂γ照射组的CAT和SOD活性均高于照射组和对照组。照射组MDA含量明显高于对照组(P<0.001),与辐照组相比,抗氧化剂γ辐照组的MDA水平降低。与对照组相比,抗氧化剂组的彗星参数显着增加,取决于碧萝精的剂量。与γ辐照相比,抗氧化剂γ辐照降低了彗星参数。由于组织病理学的结果,抗氧化组与对照组不同,在肺泡囊区域和结缔组织区域见与照射组相似的出血区域。
UNASSIGNED:我们证明,300mg/kg的碧萝精可能对全身电离辐射对肺组织的有害影响提供显著的保护作用。P300+γ射线组可显着减轻放射性肺损伤,并有可能观察到明显的保存。
UNASSIGNED: The study aims to evaluate the histopathological changes, enzymatic alterations, and DNA damage in rat lungs induced by whole-body gamma irradiation as well as evaluation of the protective effect of
pycnogenol.
UNASSIGNED: A hundred adult male rats were equally divided into ten groups including control, four antioxidants, γ-irradiation, four antioxidant + γ-irradiations. This study began the day before radiation treatment and continued for 3 days. The
pycnogenol was dissolved 5% dimethyl sulfoxide and then administered orally through a gastric tube at a dose of 37.5 mg/kg, 75 mg/kg, 150 mg/kg, and 300 mg/kg in 24, 48, and 72 h before irradiation. Irradiation was applied with a whole-body irradiation dose of 900 cGy in one fraction. DNA damage, histopathological changes, catalase (CAT), and superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in lung tissue of rats were evaluated 3 days after irradiation.
UNASSIGNED: CAT and SOD activities were found to be significantly lower in the irradiation group than control (P < 0.001). CAT and SOD activities were higher in the antioxidant + γ-irradiation group than both irradiation and control groups. MDA levels were significantly higher in the irradiation group compared to control (P < 0.001), whereas MDA levels decreased in the antioxidant + γ-irradiation group compared to the irradiation group. The antioxidant groups were significantly increased comet parameters depend on
pycnogenol doses compared to control. The antioxidant + γ-irradiation was decreased comet parameter compared to γ-irradiation. As a result of the histopathologically, the antioxidant groups were different than the control group that in the areas of alveolar sacs and connective tissue areas were seen hemorrhage areas similar to the irradiation group.
UNASSIGNED: We demonstrate that 300 mg/kg of
pycnogenol might provide significant protection against deleterious effects from whole-body ionizing radiation on the lung tissue. P300+ γ-ray group was significantly reduced radiation-induced lung injury and was possible to observe significantly preservation.