pulmonary artery pseudoaneurysm

肺动脉假性动脉瘤
  • 文章类型: Journal Article
    背景:肺动脉假性动脉瘤(PAP)破裂引起的咯血是巨大而致命的,而导致假性动脉瘤破裂的因素仍然难以捉摸。本研究旨在阐明PAP的临床和放射学特征,并确定与破裂相关的危险因素。
    方法:回顾性收集2019年1月至2022年12月发生PAP咯血的患者。人口统计学特征的临床数据,放射学发现,治疗策略,并收集预后。对破裂和未破裂病例的特征进行了比较分析。
    结果:在50例患者中发现58例PAP。最常见的原因是感染(86%)和癌症(8%)。PAP主要位于双肺的上叶,57(99.3%)分布在节段或亚节段肺动脉中。中位直径为6.1(4.3-8.7)mm。共有29个PAP被确定为邻近肺空洞,腔的中值直径为18.9(12.4-34.8)mm。21例(42%)发生假性动脉瘤破裂。与未破裂组相比,破裂组大咯血的比例明显更高(57.1%vs.6.9%,p<0.001),较大的假性动脉瘤直径(8.1±3.2mmvs.6.0±2.3mm,p=0.012),肺空洞的发生率更高(76.2%vs.44.8%,p=0.027),和更大的空化直径(32.9±18.8mmvs.15.7±8.4mm,p=0.005)。破裂组的平均肺动脉压(mPAP)也明显高于未破裂组[23.9±7.4mmHgvs.19.2±5.0mmHg,p=0.011]。21例PAP破裂患者均成功行血管内治疗,其中临床成功率为96.0%。5例患者在一年内出现反复咯血。
    结论:大咯血,假性动脉瘤直径,肺空洞,mPAP升高是假性动脉瘤破裂的危险因素。我们的发现有助于在破裂高风险下早期识别和及时干预PAP。
    BACKGROUND: Hemoptysis resulting from rupture of the pulmonary artery pseudoaneurysm (PAP) is massive and fatal, while factor contributing to the rupture of pseudoaneurysm remains elusive. This study aimed to elucidate the clinical and radiological features of PAP and identify the risk factors associated with rupture.
    METHODS: Patients who developed hemoptysis with PAP were collected from January 2019 to December 2022 retrospectively. Clinical data of the demographic characteristics, radiological findings, treatment strategies, and prognosis were collected. A comparative analysis was performed on the characteristics in the ruptured and non-ruptured cases.
    RESULTS: A total of 58 PAPs were identified in the 50 patients. The most common causes were infection (86%) and cancer (8%). The PAPs were located predominantly in the upper lobes of both lungs, and 57 (99.3%) were distributed in the segmental or subsegmental pulmonary arteries. The median diameter was 6.1(4.3-8.7) mm. A total of 29 PAPs were identified adjacent to pulmonary cavitations, with the median diameter of the cavity being 18.9 (12.4-34.8) mm. Rupture of pseudoaneurysm occurred in 21 cases (42%). Compared to unruptured group, the ruptured group had a significantly higher proportion of massive hemoptysis (57.1% vs. 6.9%, p < 0.001), larger pseudoaneurysm diameter (8.1 ± 3.2 mm vs. 6.0 ± 2.3 mm, p = 0.012), higher incidence of pulmonary cavitation (76.2% vs. 44.8%, p = 0.027), and larger cavitation diameters (32.9 ± 18.8 mm vs. 15.7 ± 8.4 mm, p = 0.005). The mean pulmonary artery pressure (mPAP) in the ruptured group was also significantly higher than that in the unruptured group [23.9 ± 7.4 mmHg vs. 19.2 ± 5.0 mmHg, p = 0.011]. Endovascular treatment was successfully performed in all 21 patients with ruptured PAP, of which the clinical success rate was 96.0%. Five patients experienced recurrent hemoptysis within one year.
    CONCLUSIONS: Massive hemoptysis, pseudoaneurysm diameter, pulmonary cavitation, and elevated mPAP were the risk factors for rupture of pseudoaneurysm. Our findings facilitate early identification and timely intervention of PAP at high risk of rupture.
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  • 文章类型: Case Reports
    UNASSIGNED: Hemoptysis is defined as coughing out of blood. Pulmonary tuberculosis is the most common cause of hemoptysis in tuberculosis-endemic countries like India. Rasmussen aneurysm is a pseudoaneurysm arising from the pulmonary artery adjacent to or within a tuberculous cavity. Chest radiographs, chest computed tomography angiography (CTA), and digital subtraction angiography (DSA) are the imaging tools for evaluating a case of hemoptysis.
    UNASSIGNED: A 32-year-old man with a history of pulmonary tuberculosis presented with complaints of recurrent hemoptysis. On imaging evaluation, multiple pulmonary artery pseudoaneurysms were seen in the left lung. The patient was shifted to the DSA lab and the pseudoaneurysms were subsequently treated by endovascular coil embolization. Hemoptysis resolved following the procedure and the patient was again started on anti-tubercular therapy.
    UNASSIGNED: Endovascular coiling is minimally invasive, safe, and effective management of multiple Rasmussen aneurysms for preventing possible torrential blood loss and unfortunate death.
    UNASSIGNED: Hemoptizė yra kosulys su krauju. Endeminėse šalyse, pavyzdžiui, Indijoje, plaučių tuberkuliozė yra dažniausia hemoptizės priežastis. Rasmusseno aneurizma yra pseudoaneurizma, atsirandanti iš plaučių arterijos, esančios šalia tuberkuliozinės ertmės arba jos viduje. Krūtinės ląstos rentgenogramos, krūtinės ląstos kompiuterinės tomografijos angiografija (KTA) ir skaitmeninė subtrakcinė angiografija (DSA) – tai vaizdinimo priemonės hemoptizės atvejui įvertinti.
    UNASSIGNED: 32 metų vyras, sirgęs plaučių tuberkulioze, skundėsi pasikartojančia hemoptize. Atlikus vaizdų vertinimą, kairiajame plautyje buvo matomos daugybinės plaučių arterijos pseudoaneurizmos. Pacientas buvo perkeltas į DSA laboratoriją, o vėliau pseudoaneurizmos gydytos endovaskuline spiraline embolizacija. Po procedūros hemoptizė išnyko ir pacientui vėl buvo pradėtas antituberkuliozinis gydymas.
    UNASSIGNED: Endovaskulinė embolizacija yra minimaliai invazinis, saugus ir veiksmingas daugybinių Rasmusseno aneurizmų gydymas, siekiant išvengti galimo didelio kraujo netekimo ir nelaimingos mirties.
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  • 文章类型: Case Reports
    肺动脉假性动脉瘤(PAP)是咯血的罕见病因。潜在的原因包括外伤,感染,或医疗干预。有破裂的危险,这与高死亡率有关。我们描述了一个72岁的病人,有肺癌病史,6年前曾接受过放化疗治疗,出现咯血的人.她的血液动力学稳定,没有其他投诉。胸部CT血管造影显示PAP源自先前照射区域的右肺动脉分支。该患者通过栓塞栓塞成功治疗。用放化疗治疗肺癌可导致PAP的发展。临床医生应该意识到这种并发症,甚至在治疗后几年。在文学中,仅描述了接受(化学)放射疗法治疗的肺癌患者中的少数PAP病例,最长间隔时间可达7年。
    Pulmonary artery pseudoaneurysm (PAP) is a rare cause of hemoptysis. Potential causes include trauma, infection, or medical interventions. There is a risk of rupture, which is associated with a high mortality rate. We describe a 72-year-old patient, with a past medical history of a lung carcinoma for which she was treated with chemoradiotherapy 6 years prior, who presented with hemoptysis. She was hemodynamically stable and there were no other complaints. CT angiography of the thorax showed a PAP originating from a branch of the right pulmonary artery in the previously irradiated area. The patient was successfully treated by an embolization with plugs. Treatment of lung carcinoma with chemoradiotherapy can result in the development of a PAP. Clinicians should be aware of this complication, even years after the therapy. In literature, only a few cases of PAP in patients treated with (chemo)radiotherapy for lung cancer are described, with a maximum interval up to 7 years.
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  • 文章类型: Case Reports
    我们介绍了一例平滑肌肉瘤转移中肺动脉假性动脉瘤形成的罕见病例,并有急性出血和随后的介入放射学治疗的证据。
    We present a rare case of pulmonary artery pseudoaneurysm formation in leiomyosarcoma metastases with evidence of acute bleeding and subsequent interventional radiological management.
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  • 文章类型: Case Reports
    肺动脉假性动脉瘤(PAP)并不常见,然而,它们经常导致咯血,并与不良预后有关。我们报告一例87岁男性患者。最初,他住进了以前的医院,诊断为左下叶肺脓肿.在第二个住院日,他出现咯血.对比增强胸部计算机断层扫描(CT)确定了感染性肺动脉假性动脉瘤。第九个住院日,肺动脉弹簧圈栓塞术成功,显著改善患者的病情。
    Pulmonary artery pseudoaneurysms (PAPs) are uncommon, yet they frequently result in hemoptysis and are associated with a poor prognosis. We report a case of an 87-year-old male patient. Initially, he was admitted to a previous hospital, and diagnosed with a lung abscess in the left lower lobe. On the second hospital day, he developed hemoptysis. A contrast-enhanced chest computed tomography (CT) identified an infectious pulmonary artery pseudoaneurysm. On the ninth hospital day, pulmonary artery coil embolization was successfully performed, significantly improving the patient\'s condition.
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  • 文章类型: Case Reports
    一名12岁的肺动脉狭窄女性因脓毒性栓塞而出现假性动脉瘤,需要密切跟进。
    A 12-year-old female with pulmonary artery stenosis developed pseudoaneurysms due to septic embolism, requiring close follow-up.
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  • 文章类型: Case Reports
    背景:鉴于2019年冠状病毒病(COVID-19)的广泛流行,疑似或确诊COVID-19的患者倾向于避免进行口腔和颈部检查。这可能会延迟Lemierre综合征等疾病的诊断,这涉及类似于COVID-19相关喉咙表现的症状。
    方法:一名24岁无任何潜在疾病的男子在就诊前7天被诊断为COVID-19。他在出现严重的COVID-19和疑似细菌性肺炎前1天被送往另一家医院;他开始接受雷姆德西韦和美罗培南的治疗。由于菌血症并发症,病人被转移到我们医院接受重症监护。第六天,患者出现咯血;进一步,计算机断层扫描(CT)扫描显示新的肺动脉假性动脉瘤。成功进行栓塞以实现止血。在以前医院进行的血液培养中,分离出核梭杆菌,提示感染的来源是宫颈.颈部CT扫描证实扁桃体周围脓肿和左颈内静脉血栓;因此,他被诊断出患有Lemierre综合征.治疗改用氨苄西林/舒巴坦,根据药敏结果。治疗6周后,患者完全康复,无并发症。
    结论:该病例强调了对疑似或诊断为COVID-19的患者进行彻底的口腔和颈部检查对于检测其他疾病引起的咽喉和颈部症状的重要性。
    BACKGROUND: Given the widespread prevalence of the coronavirus disease 2019 (COVID-19), oral and neck examinations tend to be avoided in patients with suspected or confirmed COVID-19. This might delay the diagnosis of conditions such as Lemierre\'s syndrome, which involves symptoms resembling COVID-19-related throat manifestations.
    METHODS: A 24-year-old man without any underlying conditions was diagnosed with COVID-19 7 days before presentation. He was admitted to another hospital 1 day before presentation with severe COVID-19 and suspected bacterial pneumonia; accordingly, he was started on treatment with remdesivir and meropenem. Owing to bacteremic complications, the patient was transferred to our hospital for intensive care. On the sixth day, the patient experienced hemoptysis; further, a computed tomography (CT) scan revealed new pulmonary artery pseudoaneurysms. Successful embolization was performed to achieve hemostasis. In blood cultures conducted at the previous hospital, Fusobacterium nucleatum was isolated, suggesting a cervical origin of the infection. A neck CT scan confirmed a peritonsillar abscess and left internal jugular vein thrombus; accordingly, he was diagnosed with Lemierre\'s syndrome. The treatment was switched to ampicillin/sulbactam, based on the drug susceptibility results. After 6 weeks of treatment, the patient completely recovered without complications.
    CONCLUSIONS: This case highlights the significance of thorough oral and neck examinations in patients with suspected or diagnosed COVID-19 for the detection of throat and neck symptoms caused by other conditions.
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  • 文章类型: Case Reports
    创伤性肺动脉假性动脉瘤(PAP)是罕见的发现,通常与胸部穿透性创伤有关。我们介绍了钝性创伤后肺动脉假性动脉瘤的病例。一名49岁的男子在机动车碰撞后出现。颈部的对比增强计算机断层扫描,胸部,腹部,获得的骨盆显示近端右肺动脉假性动脉瘤,小体积心包积血,左第一肋骨骨折,和左锁骨下动脉局灶性非血流限制性夹层。对于正确的PAP的管理,为了严格控制心率和血压,我们采用了艾司洛尔输注的非手术治疗策略.第二天获得超声心动图,未发现心脏压塞。24小时后进行胸部血管造影,显示右侧PAP和心包血稳定。患者在医院第11天出院回家。
    Traumatic pulmonary artery pseudoaneurysms (PAP) are rare findings and are often associated with penetrating trauma to the chest. We present a case of a pulmonary artery pseudoaneurysm following blunt trauma. A 49-year-old man presented after a motor vehicle collision. Contrast enhanced computed tomography scans of the neck, chest, abdomen, and pelvis were obtained demonstrating a proximal right pulmonary artery pseudoaneurysm, small volume hemopericardium, left first rib fracture, and focal non-flow limiting dissection of left subclavian artery. For the management of right PAP, we adopted a non-operative management strategy with an esmolol infusion for strict heart rate and blood pressure control. An echocardiogram was obtained the next day revealing no cardiac tamponade. Angiography of the chest was done after 24 h which showed stable appearance of the right PAP and hemopericardium. Patient was discharged home on hospital day 11.
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  • 文章类型: Case Reports
    动脉瘤的特征在于由于弱化导致的血管壁的局灶性扩张。两层血管壁的参与被分类为假性动脉瘤,而所有三层的参与被称为真正的动脉瘤。肿瘤性病变的参与是罕见的,但是少数报道的病例与肺动脉假性动脉瘤有关,而不是真正的肺动脉动脉瘤(PAAs)。我们的肺部转移性肉瘤患者的真实左PAA病例显示,据我们所知,这种关联以前从未报道过。
    Aneurysms are characterized by focal dilation of the blood vessel wall due to weakening. The involvement of two layers of the vessel wall is classified as a pseudoaneurysm while the involvement of all three layers is called a true aneurysm. Involvement of neoplastic lesions is rare, but the few reported cases have been associated with pulmonary artery pseudoaneurysms as opposed to true pulmonary artery aneurysms (PAAs). Our case of a true left PAA of a patient with metastatic sarcoma of the lung shows an association that has previously not been reported to the best of our knowledge.
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  • 文章类型: Journal Article
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