背景:储存晶体的组织细胞增生症(CSH)是一种罕见的疾病,其特征是含有晶体材料内含物的组织细胞积累。该实体可误诊为感染或肿瘤。我们介绍了一例特发性CSH在颈淋巴结中模仿转移性鳞状细胞癌的病例,并回顾了有关这种罕见实体的文献。
结果:患者为一名70岁男性患者,有舌根右侧鳞状细胞癌病史。患者表现为颈部淋巴结肿大,临床诊断为转移癌。术中会诊时,意外发现淋巴结表现出广泛的组织细胞增生症,含有晶体材料。由于淀粉样沉积,最终病理鉴定为“晶体储存组织细胞增生症”。未见转移癌。
结论:经过10个月的随访,病人没有疾病。据我们所知,这种不寻常的临床表现是首次描述CSH模拟转移性癌的病例.
BACKGROUND: Crystal storing histiocytosis (CSH) is a rare disorder characterized by accumulation of histiocytes containing crystalline material inclusions. This entity can be misdiagnosed as infection or tumor. We present a case of idiopathic CSH mimicking metastatic squamous cell carcinoma in a cervical lymph node and review of literature regarding this rare entity.
RESULTS: The patient was a 70-year-old man with a medical history of squamous cell carcinoma of the right base of the tongue. The patient presented with an enlarged cervical lymph node, which was clinically diagnosed as metastatic carcinoma. At intraoperative consultation, it was unexpectedly discovered that the lymph node exhibited extensive histiocytosis containing crystal materials. Final pathology identified \"crystal storing histiocytosis\" because of amyloidal depositions. No metastatic carcinoma was seen.
CONCLUSIONS: After 10 months of follow-up, the patient is disease free. To the best of our knowledge, this unusual clinical presentation is the first to describe CSH mimicking a metastatic carcinoma.