小热休克蛋白(HSPB)调节各种细胞功能。我们先前报道HSPB1,HSPB6和HSPB8各自抑制肝细胞癌(HCC)的进展。推测HSP的杂低聚化对于功能活性至关重要。这里,我们调查了HSPBs的复合物与HCC进展之间的关系。HSPB1/HSPB6复合物和HSPB1/HSPB8复合物,但不是HSPB6/HSPB8复合物,在过表达HSPB6的人HCC来源的HuH-7细胞和切除的人HCC肿瘤组织中均观察到。差异化,舞台,肿瘤大小,肝癌的静脉浸润与肝癌组织中HSPB复合物的存在呈负相关。我们的结果强烈表明,HSPB复合物的形成在HCC进展中起抑制作用。
Small heat shock proteins (HSPBs) regulate various cell functions. We previously reported that HSPB1, HSPB6, and HSPB8 each suppress the progression of hepatocellular carcinoma (HCC). The heterooligomerization of HSPs is speculated to be crucial for functional activities. Here, we investigated the relationship between the complex of HSPBs and the progression of HCC. HSPB1/HSPB6 complex and HSPB1/HSPB8 complex, but not HSPB6/HSPB8 complex, were observed in both HSPB6-overexpressing human HCC-derived HuH-7 cells and resected human HCC tumor tissue. Differentiation, stage, tumor size, and vein invasion of HCC were inversely related to the presence of HSPB complexes in the HCC tissue. Our results strongly suggest that the HSPB complex formation plays a suppressive role in the HCC progression.