背景:2019年冠状病毒病(COVID-19)对全球卫生和医疗保健系统产生了重大影响。这项回顾性研究旨在评估Jazan的COVID-19患者的生化参数与预后之间的关系,沙特阿拉伯。
方法:在建立纳入标准并获得伦理批准后,156例经逆转录聚合酶链反应(RT-PCR)证实的COVID-19患者的数据来自Samtah一家综合医院的电子病历,Jazan,从2020年4月到2021年10月。收集的数据包括患者的人口统计学和肝脏,肾,心,和电解质功能标记水平。描述性的,推论,并进行了主成分分析。
结果:生存率因年龄和体重指数(BMI)而异。统计分析表明,谷草转氨酶(AST)的水平,丙氨酸氨基转移酶(ALT),碱性磷酸酶(ALP),钠(Na),钾(K),血尿素氮(BUN),肌酐(Cr),肌酸激酶(CK),CK心肌带(MB),乳酸脱氢酶(LDH)明显高于参考值(P<0.05),如使用单样本t检验评估的。主成分分析(PCA)还揭示了这些生化标记物变化的潜在模式。这些结果表明,某些生化参数可能是监测COVID-19患者病情的有用指标。
结论:这项在Jazan的回顾性研究,沙特阿拉伯强调了COVID-19患者的生化参数与预后之间的关系。肝脏标志物水平升高,肾,心,和电解质功能提示器官损伤和失调。通过PCA识别的模式提供了对疾病严重程度的见解。监测这些参数可以作为评估COVID-19患者的有价值的指标。需要进一步的研究来验证这些发现,探索他们个性化治疗策略的潜力,并在持续的大流行期间改善患者的预后。
BACKGROUND: Coronavirus disease 2019 (COVID-19) has had a significant impact on global health and healthcare systems. This retrospective study aimed to assess the association between biochemical parameters and outcomes in COVID-19 patients in Jazan, Saudi Arabia.
METHODS: After establishing the inclusion criteria and obtaining ethical approval, data from 156 reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed COVID-19 patients were collected from electronic medical records from a general hospital in Samtah, Jazan, from April 2020 to October 2021. The collected data included patient demographics and liver, kidney, heart, and electrolyte function marker levels. Descriptive, inferential, and principal component analyses were conducted.
RESULTS: Survival rates varied according to age and body mass index (BMI). Statistical analysis demonstrated that the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), sodium (Na), potassium (K), blood urea nitrogen (BUN), creatinine (Cr), creatine kinase (CK), CK myocardial band (MB), and lactate dehydrogenase (LDH) were significantly higher (P < 0.05) than the reference values, as assessed using the one-sample t-test. Principal component analysis (PCA) also revealed an underlying pattern in the variation of these biochemical markers. These findings suggest that certain biochemical parameters may serve as useful indicators for monitoring the condition of COVID-19 patients.
CONCLUSIONS: This retrospective study in Jazan, Saudi Arabia highlights the association between biochemical parameters and outcomes in COVID-19 patients. Elevated levels of markers of liver, kidney, heart, and electrolyte function suggest organ damage and dysregulation. The pattern identified through PCA provides insights into disease severity. Monitoring these parameters may serve as valuable indicators for assessing COVID-19 patients. Further research is needed to validate these findings, explore their potential for personalized treatment strategies, and improve patient outcomes during the ongoing pandemic.