背景:我们研究的目的是使用SS-OCTA内置软件报告系统性高血压(HTN)患者的扫频源光学相干断层扫描血管造影(SS-OCTA)视网膜和脉络膜微血管的定量参数。
方法:我们进行了一项回顾性研究。这项研究纳入了51名HTN受试者的93只眼和38名健康受试者的71只眼。OCTA定量参数(血管密度(VD)和浅毛细血管丛(SCP)的中央凹无血管区(FAZ)面积,中毛细血管丛(MCP),深毛细血管丛(DCP),记录了OCTA立方体的总毛细血管丛(TCP)和脉络膜毛细血管(CC))4,5mm×4,5mm。
结果:CC中旁凹VD降低,在HTN组和对照组之间显示了DCP和TCP(p<0.05)。相反,SCP和MCP的旁凹VD没有差异(p>0.05)。亚组分析显示SCP中心VD减少,服用一种抗高血压药物的患者与用两种药物治疗的患者相比,DCP和TCP(p<0.05)。相关分析表明,虽然虚弱,HTN持续时间之间呈负相关,SCP和FAZ区域内的副凹VD,DCP和TCP(p<0,05和r<0,300)。
结论:当规范数据可用时,OCTA可能用作预防和随访HTN继发的终末器官损害的潜在工具。尽管如此,需要进一步的研究来证实这一假设。
BACKGROUND: The aim of our study is to report swept-source optical coherence tomography angiography (SS-OCTA) quantitative parameters of retinal and choroidal microvasculature in patients with systemic hypertension (HTN) using a built-in software of SS-OCTA.
METHODS: We performed a retrospective study. This study enrolled 93 eyes of 51 subjects with HTN and 71 eyes of 38 healthy subjects. OCTA quantitative parameters (vessel density (VD) and foveal avascular zone (FAZ) area of superficial capillary plexus (SCP), middle capillary plexus (MCP), deep capillary plexus (DCP), total capillary plexus (TCP) and choriocapillaris (CC)) of the OCTA cube of 4,5 mm × 4,5 mm were recorded.
RESULTS: A decrease of parafoveal VD in CC, DCP and TCP were demonstrated between HTN group and control group (p < 0,05). Conversely, no differences were demonstrated in parafoveal VD of SCP and MCP (p > 0,05). Subgroup analysis revealed a diminution of central VD at SCP, DCP and TCP in patients taking one antihypertensive drug compared to patients treated with two medications (p < 0,05). Correlation analysis showed a significant, albeit weak, negative correlation between HTN duration, and parafoveal VD in the SCP and FAZ area at SCP, DCP and TCP (p < 0,05 and r < 0,300).
CONCLUSIONS: When normative data are available, OCTA might be used as a potential tool in the prevention and follow-up of end-organ damage secondary to HTN. Nonetheless, further studies are needed to confirm this hypothesis.