preparation techniques

制备技术
  • 文章类型: Journal Article
    竹节虫是一种可食用和药用的真菌,属于担子菌,链球菌,Phallales,Phallaceae科,和竹竿属,这在中国和亚洲地区的消费者中很受欢迎。来自竹笋属物种(DPs)的多糖是具有多种健康益处的重要生物活性大分子,根据已发表的研究,包括抗肿瘤,抗氧化,抗肥胖,抗高脂血症,保肝,免疫调节,抗炎,肠道微生物群的调节,抗菌,保护肾脏,和其他药理作用。基于其丰富的药理活性,准备技术,DPs的结构特征和药理活性已被广泛研究。然而,据我们所知,没有专门的审查来阐明移民的最新进展。因此,为了填补这个空白,这篇综述提供了对DPs研究的全面概述,包括提取的最新进展,分离和纯化,结构特征,药理学性质,安全评估和潜在利用,为后续DP相关产品的研发提供理论依据。
    Dictyophora species is an edible and medicinal fungus belonging to the Basidiomycotina, Gasteromycetes, Phallales, family Phallaceae, and genus Dictyophora, which is popular with consumers in China and across various Asian regions. Polysaccharides from Dictyophora species (DPs) are important bioactive macromolecules with multiple health benefits, according to published studies, including anti-tumor, antioxidative, anti-obesity, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory, regulation of gut microbiota, antibacterial, renoprotective, and other pharmacological effects. Based on their rich pharmacological activities, the preparation techniques, structural characteristics and pharmacological activities of DPs have been extensively studied. However, to the best of our knowledge, there is no dedicated review to shed light on recent advances in DPs. Therefore, in order to fill this gap, this review provides a comprehensive overview of the research on DPs, including the latest advances in extraction, isolation and purification, structural characteristics, pharmacological properties, safety assessment and potential utilizations, which will provide a theoretical basis for the research and development of subsequent DPs-related products.
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  • 文章类型: Journal Article
    随着便携式可穿戴设备的蓬勃发展和巨大需求,基于功能纤维的可穿戴电子产品在各种储能领域不断涌现,运动监测,疾病预防,电磁干扰(EMI)屏蔽,等。MXene,作为一种新兴的二维无机化合物,由于其自身良好的力学性能,在功能纤维制造中显示出巨大的潜力,并引起了许多研究关注,高导电性,优异的电化学性能和良好的加工性能。在这里,本文综述了近年来MXene基纤维的研究进展。谈到MXene分散体,MXene分散体的性质,包括分散稳定性,流变性能和液晶性。用于生产MXene基纤维的制备技术以及MXene基纤维在超级电容器中的应用进展,传感器,总结了EMI屏蔽和焦耳加热器。提出了未来围绕MXene基纤维发展的挑战和前景。这篇综述旨在为MXene基纤维制造提供加工指南,从而实现基于MXene的光纤在高级应用中的更多可能性,以期为智能可穿戴设备领域注入更多活力。
    With the vigorous development and huge demand for portable wearable devices, wearable electronics based on functional fibers continue to emerge in a wide range of energy storage, motion monitoring, disease prevention, electromagnetic interference (EMI) shielding, etc. MXene, as an emerging two-dimensional inorganic compound, has shown great potential in functional fiber manufacturing and has attracted much research attention due to its own good mechanical properties, high electrical conductivity, excellent electrochemical properties and favorable processability. Herein, this paper reviews recent advances of MXene-based fibers. Speaking to MXene dispersions, the properties of MXene dispersions including dispersion stability, rheological properties and liquid crystalline properties are highlighted. The preparation techniques used to produce MXene-based fibers and application progress regarding MXene-based fibers into supercapacitors, sensors, EMI shielding and Joule heaters are summarized. Challenges and prospects surrounding the development of MXene-based fibers are proposed in future. This review aims to provide processing guidelines for MXene-based fiber manufacturing, thereby achieving more possibilities of MXene-based fibers in advanced applications with a view to injecting more vitality into the field of smart wearables.
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  • 文章类型: Journal Article
    纤维素水凝胶,由纤维素或其衍生物通过物理或化学交联形成三维网络,以其卓越的吸水能力和生物相容性而闻名。对可持续材料的不断增长的需求激发了人们对纤维素水凝胶的兴趣,归因于他们丰富的供应,生物降解性,和无毒的性质。这些特性突出了它们在包括生物医学在内的各个领域的广泛潜力,食品工业,和环境保护。纤维素水凝胶在药物递送等应用中特别有利,伤口敷料,和水处理。最近的大规模研究提高了我们对纤维素制备及其应用的理解。这篇综述深入研究了基本概念,制备技术,以及纤维素水凝胶在各个领域的应用现状。它还讨论了纳米木质素基水凝胶的最新进展,提供这种有前途的材料的全面概述,并为未来的研究和开发提供见解和指导。
    Cellulose hydrogels, formed either through physical or chemical cross-linking into a three-dimensional network from cellulose or its derivatives, are renowned for their exceptional water absorption capacities and biocompatibility. Rising demands for sustainable materials have spurred interest in cellulose hydrogels, attributed to their abundant supply, biodegradability, and non-toxic nature. These properties highlight their extensive potential across various sectors including biomedicine, the food industry, and environmental protection. Cellulose hydrogels are particularly advantageous in applications such as drug delivery, wound dressing, and water treatment. Recent large-scale studies have advanced our understanding of cellulose preparation and its applications. This review delves into the fundamental concepts, preparation techniques, and current applications of cellulose hydrogels in diverse fields. It also discusses the latest advances in nano-lignin-based hydrogels, providing a comprehensive overview of this promising material and offering insights and guidance for future research and development.
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  • 文章类型: Journal Article
    山药是重要的主食和淀粉来源,特别是在热带和亚热带地区,在世界十大块茎作物中排名第四。山药块茎富含必需的营养物质和多种有益的植物化合物,这有助于他们多方面的有益功能。此外,山药中丰富的淀粉和抗性淀粉(RS)含量可以满足市场对RS的需求。山药淀粉和RS的固有和改性特性使它们成为多种食品的通用成分,有潜力成为食品工业中最具成本效益的原材料之一。近年来,山药RS的研究经历了逐步扩展。本文全面总结了山药淀粉及其RS的最新研究成果,阐明了RS商业化生产的可行性以及该技术对淀粉理化性质的影响。山药已成为可持续RS生产的有前途的块茎淀粉储库,与热,化学,酶和组合处理被证明是RS的有效制造程序。山药RS的适应性允许广泛的食品应用。
    Yam is a significant staple food and starch source, particularly in tropical and subtropical regions, holding the fourth position among the world\'s top ten tuber crops. Yam tubers are rich in essential nutrients and a diverse range of beneficial plant compounds, which contribute to their multifaceted beneficial functions. Furthermore, the abundant starch and resistant starch (RS) content in yam can fulfil the market demand for RS. The inherent and modified properties of yam starch and RS make them versatile ingredients for a wide range of food products, with the potential to become one of the most cost-effective raw materials in the food industry. In recent years, research on yam RS has experienced progressive expansion. This article provides a comprehensive summary of the latest research findings on yam starch and its RS, elucidating the feasibility of commercial RS production and the technology\'s impact on the physical and chemical properties of starch. Yam has emerged as a promising reservoir of tuber starch for sustainable RS production, with thermal, chemical, enzymatic and combination treatments proving to be effective manufacturing procedures for RS. The adaptability of yam RS allows for a wide range of food applications.
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  • 文章类型: Journal Article
    固体脂质纳米颗粒(SLN)由于其生物相容性和生物降解性,在制药行业中获得了广泛的关注,使它们成为受欢迎的功能性纳米载体。SLN是一种流行的纳米载体,因为它们能够绕过脾脏和肝脏,提供高药物稳定性,提高生物利用度,灭菌,固定化,靶向药物释放,和生物相容性成分。本文讨论了各种SLN制备技术,包括高剪切均化,热均质化,冷均质化,基于微乳液的,溶剂蒸发,溶剂乳化-蒸发,基于超临界流体,喷雾干燥,双乳液,和降水技术,注重方法论方面。这篇综述讨论了SLN的物理化学行为,包括药物装载,释放,颗粒大小,稳定性,细胞毒性,和细胞摄取,以及它们的主要生物医学应用。
    Solid lipid nanoparticles (SLNs) are gaining significant attention in the pharmaceutical industry due to their biocompatibility and biodegradability, making them a popular functional nanocarrier. SLNs are a popular nanocarrier due to their ability to bypass the spleen and liver, offer high drug stability, and improve bioavailability, sterilization, immobilization, targeted drug release, and biocompatible ingredients. This article discusses various SLN preparation techniques, including high shear homogenization, hot homogenization, cold homogenization, microemulsion-based, solvent evaporation, solvent emulsification-evaporation, supercritical fluid-based, spray drying, double emulsion, and precipitation techniques, focusing on methodological aspects. This review discusses the physicochemical behavior of SLNs, including drug loading, release, particle size, stability, cytotoxicity, and cellular uptake, and their major biomedical applications.
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  • 文章类型: Journal Article
    多糖,由于它们的显著特征,在纳米粒子(NPs)的可持续生产中获得了显著的突出地位。市场需求大,生产成本最低,与化学合成的NP相比,展示了对环境良性的基于多糖的纳米颗粒(PSNP)的驱动。各种方法用于PSNP的合成,包括交联,聚电解质络合,和自我组装。PSNPs有可能取代食品中广泛多样的基于化学的试剂,健康,医疗和制药部门。然而,与优化PSNP的特性以满足特定的靶向应用相关的相当大的挑战至关重要。这篇综述详细汇编了PSNP综合方面的最新成就,支配它们合理制造的基本原则和关键因素,以及各种表征技术。值得注意的是,PSNPs在生物医学等不同学科中的多次使用,化妆品农用化学品,储能,水解毒,和食物相关的领域,详细说明了。解决了PSNPs的毒理学影响及其对人类健康的可能风险的见解,强调了在PSNPs开发和优化策略方面所做的努力,这些策略可以增强交付。最后,局限性,潜在的缺点,市场扩散,还讨论了PSNPs实现广泛商业用途的经济可行性和未来可能性。
    Polysaccharides, due to their remarkable features, have gained significant prominence in the sustainable production of nanoparticles (NPs). High market demand and minimal production cost, compared to the chemically synthesised NPs, demonstrate a drive towards polysaccharide-based nanoparticles (PSNPs) benign to environment. Various approaches are used for the synthesis of PSNPs including cross-linking, polyelectrolyte complexation, and self-assembly. PSNPs have the potential to replace a wide diversity of chemical-based agents within the food, health, medical and pharmacy sectors. Nevertheless, the considerable challenges associated with optimising the characteristics of PSNPs to meet specific targeting applications are of utmost importance. This review provides a detailed compilation of recent accomplishments in the synthesis of PSNPs, the fundamental principles and critical factors that govern their rational fabrication, as well as various characterisation techniques. Noteworthy, the multiple use of PSNPs in different disciplines such as biomedical, cosmetics agrochemicals, energy storage, water detoxification, and food-related realms, is accounted in detail. Insights into the toxicological impacts of the PSNPs and their possible risks to human health are addressed, and efforts made in terms of PSNPs development and optimising strategies that allow for enhanced delivery are highlighted. Finally, limitations, potential drawbacks, market diffusion, economic viability and future possibilities for PSNPs to achieve widespread commercial use are also discussed.
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  • 文章类型: Journal Article
    巨型单层囊泡(GUV)是多功能且有前途的细胞大小的生物膜模拟平台。它们的应用范围从理解和量化膜生物物理过程到充当合成细胞的自底向上组装的基本模块。GUV的确定属性和必要目标取决于对其应用成功至关重要的制备技术。这里,我们回顾了巨大单层囊泡制备技术的关键进展,并讨论了它们的形成机制。描述了用于GUV制备的脂质水合和乳化技术的发展。概述了涉及脂质或表面活性剂稳定的乳液的新型基于微流体的技术。总结了GUV固定化策略,包括基于重力的沉降,共价连接,通过微流体固定,电动,磁障。此外,在过去的十年中,已经确定了GUV作为仿生和合成细胞平台的一些关键应用。膜界面过程如相分离,膜蛋白重建,和膜弯曲已使用GUV解密。此外,囊泡也被用作构建块,以构建具有确定的细胞样功能的合成细胞,包括隔室,代谢反应器,以及成长和分裂的能力。我们批判性地讨论了制备技术的利弊以及它们赋予GUV的属性,并确定了专用应用的潜在技术。
    Giant unilamellar vesicles (GUVs) are versatile and promising cell-sized bio-membrane mimetic platforms. Their applications range from understanding and quantifying membrane biophysical processes to acting as elementary blocks in the bottom-up assembly of synthetic cells. Definite properties and requisite goals in GUVs are dictated by the preparation techniques critical to the success of their applications. Here, we review key advances in giant unilamellar vesicle preparation techniques and discuss their formation mechanisms. Developments in lipid hydration and emulsion techniques for GUV preparation are described. Novel microfluidic-based techniques involving lipid or surfactant-stabilized emulsions are outlined. GUV immobilization strategies are summarized, including gravity-based settling, covalent linking, and immobilization by microfluidic, electric, and magnetic barriers. Moreover, some of the key applications of GUVs as biomimetic and synthetic cell platforms during the last decade have been identified. Membrane interface processes like phase separation, membrane protein reconstitution, and membrane bending have been deciphered using GUVs. In addition, vesicles are also employed as building blocks to construct synthetic cells with defined cell-like functions comprising compartments, metabolic reactors, and abilities to grow and divide. We critically discuss the pros and cons of preparation technologies and the properties they confer to the GUVs and identify potential techniques for dedicated applications.
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  • 文章类型: Journal Article
    在热带和亚热带地区,块茎和块根作物是主食和能源的主要来源。甘薯(SP)因其大小多样,目前被认为是世界十大食品之一,形状,颜色,和健康益处。SP的抗性淀粉(RS)含量是相当大的。由于其种类繁多,预计将成为食品工业中最便宜的产品,食品稳定性,乳化剂和脂肪替代能力,作为填料。因此,最近对SP采购RS的兴趣有所增加。由于其独特的营养和功能品质,新颖性已成为近年来的热门研究热点。这篇综述将总结目前对SP淀粉成分的理解及其对生产淀粉的技术和理化性质的影响,以实现商业可行性。强调了甘薯RS在解决未来RS需求可持续性方面的重要性。作为RS生产的可持续原料,SP是块茎的可行替代品。由于其固有的营养价值和气候耐受性,它比块茎具有优势。热,化学,和酶处理是有效的RS制造程序。甘薯RS的适应性允许广泛的食品应用。
    In tropical and subtropical areas, tuber and root crops are staple foods and a key source of energy. Sweet potato (SP) is currently regarded as one of the world\'s top ten foods because of its diverse sizes, shapes, color, and health benefits. The resistant starch (RS) content of SP is substantial. It is predicted to become the cheapest item in the food industry due to its extensive variety, food stability, emulsifier and fat substitution capabilities, and as filler. As a result, interest in SP-sourced RS has recently increased. Due to their unique nutritional and functional qualities, novelty has become a popular research focus in recent years. This review will summarize the current understanding of SP starch components and their impact on the technological and physicochemical properties of produced starch for commercial viability. The importance of sweet potato RS in addressing future RS demand sustainability is emphasized. SPs are a viable alternative to tubers as a sustainable raw material for RS production. It has an advantage over tubers because of its intrinsic nutritional value and climatic endurance. Thermal, chemical, and enzymatic treatments are effective RS manufacturing procedures. The adaptability of sweet potato RS allows for a wide range of food applications.
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  • 文章类型: Journal Article
    药物物质的持续释放仍然是最方便的药物递送方式。因此,在与药物递送系统(DDS)相关的公开文献中可以追溯到各种各样的报道。具体来说,在过去的二十年中,微粒系统的使用受到了特别的关注。聚合物微粒(MP)被认为是非常普遍的载体,用于提高亲水性和亲脂性药物物质的生物分布和生物利用度。聚乳酸(PLA),聚(乳酸-乙醇酸)(PLGA),和它们的共聚物是用于包封药物的最常用的生物可降解聚合物之一。这篇综述描述了目前在研究聚乳酸/聚乳酸共乙醇酸微粒和聚乳酸共聚物与其他脂肪酸作为药物递送装置以提高药物递送效率方面的最新研究。增强释放曲线,和药物靶向活性药物成分(API)。仿制药的潜在进展和治疗性肽的不断发现将有望促进微球技术的成功。
    The sustained release of pharmaceutical substances remains the most convenient way of drug delivery. Hence, a great variety of reports can be traced in the open literature associated with drug delivery systems (DDS). Specifically, the use of microparticle systems has received special attention during the past two decades. Polymeric microparticles (MPs) are acknowledged as very prevalent carriers toward an enhanced bio-distribution and bioavailability of both hydrophilic and lipophilic drug substances. Poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and their copolymers are among the most frequently used biodegradable polymers for encapsulated drugs. This review describes the current state-of-the-art research in the study of poly(lactic acid)/poly(lactic-co-glycolic acid) microparticles and PLA-copolymers with other aliphatic acids as drug delivery devices for increasing the efficiency of drug delivery, enhancing the release profile, and drug targeting of active pharmaceutical ingredients (API). Potential advances in generics and the constant discovery of therapeutic peptides will hopefully promote the success of microsphere technology.
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  • 文章类型: Journal Article
    纳米结构脂质载体(NLC)被开发为替代载体系统,优化了表面真菌感染的局部治疗中的局限性。例如通过皮肤的有限渗透。然而,很少有发表的研究集中在这些脂质纳米系统质量的决定变量的标准化和表征。因此,本系统综述旨在收集有关脂质选择的信息,表面活性剂,以及与该纳米技术的最终质量密切相关的制备方法。为此,搜索使用以下描述符进行:“纳米结构脂质载体”,\'局部\',用布尔运算符\'和\'分隔的\'抗真菌药\',出现在数据库的标题中:科学直接,Scopus和Pubmed。该综述包括实验文章,重点是开发具有抗真菌活性的纳米结构脂质载体,从2015年到2021年出版。评论文章,临床研究,研究中排除了用于其他给药途径的其他纳米载体的开发研究。这项研究包括26篇文章,其中58%是在印度和巴西开发的,53%在2019年和2020年发布。至于纳入NLC的抗真菌药物的选择,唑类比其他类更有偏好,伏立康唑被纳入研究的26个开发的NLC中的5个。还观察到作为液体脂质的中链甘油三酯(MCT)和作为表面活性剂的聚山梨醇酯80占优势。在其他结果中,这篇综述汇编了NLC质量参数中讨论的每个变量的影响,以指导未来涉及该技术发展的研究。图形抽象。
    Nanostructured lipid carriers (NLC) were developed as an alternative carrier system optimizing limitations found in topical treatments for superficial fungal infections, such as limited permeation through the skin. However, few published studies are focused on standardization and characterization of determinant variables of these lipid nanosystems\' quality. Thus, this systematic review aims to compile information regarding the selection of lipids, surfactants, and preparation method that intimately relates to the final quality of this nanotechnology. For this, the search was carried with the following descriptors: \'nanostructured lipid carriers\', \'topical\', \'antifungal\' separated by the Boolean operators \'and\', present in the titles of the databases: Science Direct, Scopus and Pubmed. The review included experimental articles focused on the development of nanostructured lipid carriers targeted for topical application with antifungal activity, published from 2015 to 2021. Review articles, clinical studies, and studies on the development of other nanocarriers intended for other routes of administration were excluded from the study. The research included 26 articles, of which 58% were developed in India and Brazil, 53% published in the years 2019 and 2020. As for the selection of antifungal drugs incorporated into NLCs, the azole class had a preference over other classes, voriconazole being incorporated into 5 of the 26 developed NLC studied. It was also observed a predominance of medium chain triglycerides (MCT) as a liquid lipid and polysorbate 80 as a surfactant. Among other results, this review compiles the influences of each of the variables discussed in the quality parameters of NLCs, in order to guide future research involving the development of this technology. Graphical Abstract.
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