pregnancy and heart disease

妊娠和心脏病
  • 文章类型: Case Reports
    我们讨论了一种情况,即临床绒毛膜羊膜炎和D-二聚体水平升高的患者的血液培养能够早期诊断感染性心内膜炎。一名怀孕39周的31岁女性因发烧出现在产科。心脏造影显示胎儿心动过速和严重的晚期减速。术前检查显示白细胞计数为15,900/μL,D-二聚体水平为86.2μg/mL。由于临床绒毛膜羊膜炎,她被诊断出胎儿状况令人不放心;因此,进行了紧急剖宫产术.影像学检查排除了血栓栓塞的可能性。随后的母体血液培养对金黄色葡萄球菌呈阳性。超声心动图显示主动脉瓣上有植被,导致感染性心内膜炎的诊断。血培养可用于评估D-二聚体水平升高的临床绒毛膜羊膜炎的败血症,因为它们可能有助于妊娠期间感染性心内膜炎的早期诊断。
    We discuss a case where the blood cultures of a patient with clinical chorioamnionitis and elevated D-dimer levels enabled early diagnosis of infective endocarditis. A 31-year-old female with a 39-week pregnancy presented to the obstetrics department with a fever. Cardiotocography revealed fetal tachycardia and severe late deceleration. Preoperative examinations revealed a leukocyte count of 15,900/μL and D-dimer levels of 86.2 μg/mL. She was diagnosed with a non-reassuring fetal status due to clinical chorioamnionitis; accordingly, an emergency cesarean section was performed. Imaging studies ruled out the possibility of a thromboembolism. Subsequent maternal blood cultures were positive for Staphylococcus aureus. Echocardiography revealed vegetation on the aortic valve, leading to a diagnosis of infective endocarditis. Blood cultures can be useful in evaluating for sepsis in cases of clinical chorioamnionitis with elevated D-dimer levels as they may facilitate early diagnosis of infective endocarditis during pregnancy.
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  • 文章类型: Journal Article
    许多患有先天性心脏病(CHD)的妇女希望安全和成功怀孕,但很大一部分不寻求孕前咨询。
    这项研究旨在区分这个不断增长的人口中对怀孕的个人优先事项和看法。
    年龄在18至50岁的CHD女性从2个研究点登记。使用混合方法方法(Q-methodology),179名参与者对23条陈述进行了分类,这些陈述代表了关于怀孕的观点的集合,使用了从“强烈同意”到“强烈不同意”的优先强制排名。\"
    大多数女性年龄在25至29岁之间,患有中度或重度复杂冠心病,结婚了.从患者的反应中阐明了五个独特的群体身份。第一组围绕着建立家庭的强烈愿望。第2组的女性有明显的焦虑,他们的心理健康干扰了他们组建家庭的决定。第3组的妇女担心过早死亡;如果她们有孩子,他们想活着看到他们变老。第4组的妇女强烈反对终止合同。第5组重视医疗保健参与。群体身份与冠心病复杂性和人口统计学因素如年龄和婚姻状况无关。确定了六个区分性陈述,这些陈述有助于区分女性与哪个组保持一致。
    患有冠心病的女性在妊娠和心脏病方面有不同的优先事项和价值观。本研究使用混合方法方法提供了一个框架,确定了冠心病女性有针对性的孕前咨询的几个领域。
    UNASSIGNED: Many women with congenital heart disease (CHD) desire safe and successful pregnancies, but a significant proportion does not seek prepregnancy counseling.
    UNASSIGNED: This study aims to distinguish the personal priorities and perceptions about pregnancy in this growing population.
    UNASSIGNED: Women aged 18 to 50 years with CHD were enrolled from 2 sites. Using a mixed-methods approach (Q-methodology), 179 participants sorted 23 statements representing a collection of views on pregnancy using priority forced ranking along a scale from \"strongly agree\" to \"strongly disagree.\"
    UNASSIGNED: Majority of women were between 25 and 29 years of age, had moderate or severely complex CHD, and were married. Five unique group identities were elucidated from patient responses. Group 1 was centered around a strong desire to start a family. Women in group 2 had significant anxiety, and their psychological wellbeing interfered with their decision to start a family. Women in group 3 were concerned about premature death; if they do have kids, they want to be alive to see them grow old. Women in group 4 had strong objections to termination. Group 5 valued health care engagement. Group identities were unrelated to CHD complexity and demographic factors such as age and marital status. Six differentiating statements were identified that help distinguish which group a woman aligns with.
    UNASSIGNED: Women with CHD have diverse priorities and values relating to pregnancy and heart disease. This study used a mixed-methods approach to provide a framework identifying several domains for targeted prepregnancy counseling in women with CHD.
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  • 文章类型: Case Reports
    怀孕是大多数女性的主要生活事件,会导致广泛的生理变化。因此,它与患有先天性心脏病的女性的额外风险有关。没有发表有关怀孕或由没有房间隔缺损的孤立性右心室发育不全的妇女所生的婴儿的报告。在这种情况下,患者的右心室很小,没有收缩力。右心房高度扩大,其收缩性导致肺循环无肺动脉高压。分娩后的尺寸比怀孕前增加。幸运的是,一个健康的婴儿出生时没有任何右心衰竭症状。
    Pregnancy is a major life event for most women that causes extensive physiological changes. Hence, it is associated with additional risks in women with congenital heart disease. No reports of pregnancy or a baby born to a woman with isolated right ventricular hypoplasia without an atrial septal defect have been published. In this case, the patient\'s right ventricle was very small with no contractility. The right atrium was highly enlarged, and its contractility resulted in pulmonary circulation without pulmonary hypertension. The size increased post-delivery than that before pregnancy. Fortunately, a healthy infant was born without any right heart failure symptoms.
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  • 文章类型: Case Reports
    先天性完全性心脏传导阻滞是罕见的。在某些情况下,它保持无症状,直到成年或在妇女的情况下,直到怀孕。它通常继发于母体抗体的胎盘转移,并与高死亡率和发病率相关。我们介绍了一例积极分娩的产妇,胎膜早破和胎动减少。我们发现,患者有一个完整的心脏传导阻滞和轻度的努力不耐受评估。代谢和缺血原因的标志物为阴性,我们做了先天性完全性心脏传导阻滞的临时诊断.患者在脊髓麻醉和临时起搏器备用下进行了下段剖腹产。术后,患者接受了永久性起搏器植入术.此病例报告强调了标准的美国麻醉医师协会(ASA)监测的重要性,包括12导联心电图(ECG),这可以证明在可怕的情况下具有决定性和挽救生命。
    Congenital complete heart block is a rare occurrence. In some cases, it remains asymptomatic until adulthood or in the case of women until pregnancy. It is usually secondary to placental transfer of maternal antibodies and is associated with high mortality and morbidity. We present a case of a parturient who presented in active labor with premature rupture of membranes and decreased fetal movements. We found that the patient had a complete heart block with mild effort intolerance on evaluation. Markers for metabolic and ischemic causes were negative, and we made a provisional diagnosis of congenital complete heart block. The patient underwent a lower section cesarian section under spinal anesthesia with temporary pacemaker backup. Postoperatively, the patient underwent permanent pacemaker implantation. This case report underlines the importance of standard American Society of Anesthesiologists (ASA) monitoring, including a 12-lead electrocardiogram (ECG), which could prove decisive and life-saving in dire circumstances.
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  • 文章类型: Case Reports
    Atrioventricular (AV) block in pregnancy is infrequently encountered and there is little management guidance available. We present a case of a 24-year-old G3P1011 at 24 weeks\' gestation who presented to the obstetrics and gynecology clinic complaining of palpitations, fatigue, and dyspnea on exertion. Cardiology workup including an electrocardiogram (ECG) and Holter monitor detected second-degree type II (Mobitz) AV block with the longest asystole event lasting 15.8 seconds.  A St. Jude\'s dual-chamber pacemaker (Abbott Laboratories, Abbott Park, IL) was implanted immediately. Standard radiation precautions were taken with additional shielding for the fetus. The patient experienced significant improvement in her symptoms. The patient went into labor at 37 3/7 weeks. Due to non-reassuring fetal heart tones, a cesarean section was performed, and a healthy baby girl was born.  The management of heart block in pregnancy can be divided into involving those who are symptomatic and those who are asymptomatic. Symptoms of heart block can include palpitations, fatigue, dyspnea, and/or syncope; the presence of these symptoms warrants the placement of a pacemaker, preferably during pre-pregnancy or during the first two trimesters, as high-grade heart block is associated with significant mortality. Those who are in their last trimester or postpartum should consider the use of a temporary pacemaker as heart block could be due to pregnancy-related cardiovascular changes.  For women with heart block, labor and delivery could result in worsening of bradycardia due to uterine contractions displacing blood into the central circulation. Most women with heart block do well in labor and delivery and having a pacemaker is not necessarily an indication for a cesarean section.
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  • 文章类型: Journal Article
    目的:这些妇女妊娠期间的心房颤动(AF)/房扑(AFL)与妊娠不良结局有关。
    背景:发病率,定时,心脏病患者妊娠期间AF或AFL的后果尚不清楚。
    方法:2008年1月至2011年6月,28个国家的60家医院前瞻性地纳入了1,321例先天性心脏病孕妇,心脏瓣膜病,缺血性心脏病,或ROPAC(妊娠和心脏病注册)中的心肌病。我们研究了发病率,发病,以及妊娠期AF/AFL的预测因素,并评估妊娠结局。提供了现有文献的概述。
    结果:17名妇女(1.3%)在怀孕期间发生AF/AFL,主要在孕中期(61.5%)。单变量分析确定了以下妊娠中AF/AFL的孕前危险因素:妊娠前AF/AFL(比值比[OR]:7.1,95%置信区间[CI]:1.5至32.8);二尖瓣心脏病(OR:6.9,95%CI:2.6至18.3);使用β受体阻滞剂(OR:3.3,95%CI:1.2至9.0);左侧病变(OR:2.9至95%CI:8.3)。有AF/AFL的女性产妇死亡率高于无AF/AFL的女性(11.8%vs.0.9%;p=0.01),虽然心力衰竭并不常见。低出生体重(<2,500g)在女性中的发生率高于无AF/AFL的女性(35%vs.14%;p=0.02)。
    结论:AF/AFL发生在1.3%的妊娠结构性心脏病患者中,在妊娠中期末期达到峰值。心脏病患者妊娠期间的AF/AFL与不良的母体结局有关,并且对胎儿出生体重也有影响。
    OBJECTIVE: Atrial fibrillation (AF)/atrial flutter (AFL) during pregnancy in these women is associated with adverse outcome of pregnancy.
    BACKGROUND: The incidence, timing, and consequences of AF or AFL during pregnancy in patients with heart disease are not well known.
    METHODS: Between January 2008 to June 2011, 60 hospitals in 28 countries prospectively enrolled 1,321 pregnant women with congenital heart disease, valvular heart disease, ischemic heart disease, or cardiomyopathy in the ROPAC (Registry of Pregnancy and Cardiac Disease). We studied the incidence, onset, and predictors of AF/AFL during pregnancy and assessed the pregnancy outcome. An overview of the existing literature is provided.
    RESULTS: Seventeen women (1.3%) developed AF/AFL during pregnancy, mainly in the second trimester (61.5%). Univariable analysis identified the following pre-pregnancy risk factors for AF/AFL in pregnancy: AF/AFL before pregnancy (odds ratio [OR]: 7.1, 95% confidence interval [CI]: 1.5 to 32.8); mitral valvular heart disease (OR: 6.9, 95% CI: 2.6 to 18.3); beta-blocker use (OR: 3.3, 95% CI: 1.2 to 9.0); and left-sided lesions (OR: 2.9, 95% CI: 1.0 to 8.3). Maternal mortality was higher in women with than in women without AF/AFL (11.8% vs. 0.9%; p = 0.01), although heart failure was not seen more often. Low birth weight (<2,500 g) occurred more often in women with than in women without AF/AFL (35% vs. 14%; p = 0.02).
    CONCLUSIONS: AF/AFL occurs in 1.3% of pregnant patients with structural heart disease with a peak at the end of the second trimester. AF/AFL during pregnancy in cardiac patients is associated with unfavorable maternal outcome and also has an impact on fetal birth weight.
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  • 文章类型: Letter
    暂无摘要。
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