prediction models

预测模型
  • 文章类型: Journal Article
    本研究介绍了一种使用非对称卷积块(ACB)识别高效钙钛矿材料的创新方法。我们的方法涉及对钙钛矿氧化物材料的大量数据进行预处理,并开发精确的预测模型。该系统旨在准确预测带隙和稳定性等关键特性,从而消除了对传统特征重要性过滤的依赖。它表现突出,在分类任务中达到96.8%的准确率和0.998的召回率,在回归任务中,决定系数(R2)值为0.993,均方误差(MSE)为0.004。值得注意的是,DyCoO3和YVO3由于其最佳带隙而被确定为光伏应用的有希望的候选者。这种高效而精确的方法极大地推进了太阳能电池先进材料的开发,为快速材料筛选提供了一个强大的框架。
    This study introduces an innovative method for identifying high-efficiency perovskite materials using an asymmetric convolution block (ACB). Our approach involves preprocessing extensive data on perovskite oxide materials and developing a precise predictive model. This system is designed to accurately predict key properties such as band gap and stability, thereby eliminating the reliance on traditional feature importance filtering. It exhibited outstanding performance, achieving an accuracy of 96.8% and a recall of 0.998 in classification tasks, and a coefficient of determination (R2) value of 0.993 with a mean squared error (MSE) of 0.004 in regression tasks. Notably, DyCoO3 and YVO3 were identified as promising candidates for photovoltaic applications due to their optimal band gaps. This efficient and precise method significantly advances the development of advanced materials for solar cells, providing a robust framework for rapid material screening.
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  • 文章类型: Journal Article
    研究影响水分含量的主要因素对于研究真空过滤机理至关重要。鉴于目前实验数据不足,影响滤饼水分含量的主导因素尚未确定,在这项研究中,设计和建造了真空过滤装置。石英砂颗粒用作过滤材料。在不同的实验条件下获得了300个滤饼水分含量的数据集。多元线性回归,人工神经网络,决策树,随机森林,采用极端梯度提升法建立真空筛选过程中水分含量的预测模型。通过综合分析特征重要性排序以及正相关和负相关的影响,真空筛选过程中影响滤饼水分含量的主要因素是颗粒比,筛网,和气流速率。这一发现不仅为真空筛分技术的优化提供了科学依据,而且为实际应用中提高筛分效率指明了道路。这对于加深对真空筛分机理的认识和促进其广泛应用具有重要意义。
    The study of the dominant factors influencing moisture content is essential for investigating vacuum filtration mechanisms. In view of the present situation where there is insufficient experimental data and the dominant factors influencing the moisture content of a filter cake have not been identified, in this study a vacuum filtration apparatus was designed and constructed. Quartz sand particles were used as the filtration material. 300 datasets of moisture contents of a filter cake were obtained under different experimental conditions. Multiple Linear Regression, artificial neural network, decision tree, random forest, and extreme gradient boosting were used to establish a prediction model for moisture content during vacuum screening. By comprehensively analyzing the feature importance rankings and the effects of positive and negative correlations, the dominant factors influencing the moisture content of the filter cake during vacuum screening were the particle ratio, screen mesh, and airflow rate. This finding not only provides a scientific basis for the optimization of vacuum screening technology but also points the way for improving screening efficiency in practical applications. It is of significant importance for deepening the understanding of the vacuum screening mechanism and promoting its extensive application.
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  • 文章类型: Journal Article
    目的:为了评估RIETE的辨别能力和校准,Kuijer,和HAS-BLED模型预测静脉血栓栓塞(VTE)抗凝患者3个月出血风险。
    方法:基于圣伊格纳西奥医院VTE患者回顾性队列研究的预测模型的外部验证研究,波哥大(哥伦比亚),2021年7月至2023年6月。使用Hosmer-Lemeshow测试和每个风险类别中观察到的事件与预期事件(ROE)的比率来评估量表的校准。使用ROC曲线的曲线下面积(AUC)评估辨别能力。
    结果:我们分析了470例患者(中位年龄65岁,女性59.3%)在大多数情况下诊断为深静脉血栓形成(57.4%),观察到5.7%的出血事件。关于校准,鉴于事件数量有限,不能排除适当的校准。Kuijer评分的曲线下面积(AUC)为0.48(CI0.37-0.59),HAS-BLED为0.58(CI0.47-0.70),RIETE为0.64(CI0.51-0.76)。
    结论:Kuijer,BLED,VTE患者的RIETE模型通常不能充分估计3个月时的出血风险,辨别高危患者的能力较低。建议谨慎解释,直到有进一步的证据为止。
    OBJECTIVE: To evaluate the discriminative ability and calibration of the RIETE, Kuijer, and HAS-BLED models for predicting 3-month bleeding risk in patients anticoagulated for venous thromboembolism (VTE).
    METHODS: External validation study of a prediction model based on a retrospective cohort of patients with VTE seen at the Hospital Universitario San Ignacio, Bogotá (Colombia) between July 2021 and June 2023. The calibration of the scales was evaluated using the Hosmer-Lemeshow test and the ratio of observed to expected events (ROE) within each risk category. Discriminatory ability was assessed using the area under the curve (AUC) of a ROC curve.
    RESULTS: We analyzed 470 patients (median age 65 years, female sex 59.3%) with a diagnosis of deep vein thrombosis in most cases (57.4%), 5.7% bleeding events were observed. Regarding calibration, adequate calibration cannot be ruled out given the limited number of events. The discriminatory ability was limited with an area under the curve (AUC) of 0.48 (CI 0.37-0.59) for Kuijer Score, 0.58 (CI 0.47-0.70) for HAS-BLED and 0.64 (CI 0.51-0.76) for RIETE.
    CONCLUSIONS: The Kuijer, HAS-BLED, and RIETE models in patients with VTE generally do not adequately estimate the risk of bleeding at three months, with a low ability to discriminate high-risk patients. Cautious interpretation is recommended until further evidence is available.
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  • 文章类型: Journal Article
    艾滋病毒和结核病都是慢性传染病,需要长期治疗和随访。导致大量的电子病历。随着健康和医疗大数据的指数增长,对这些数据进行有效的提取和分析成为研究热点。作为人工智能的一个基本方面,机器学习在医学研究中得到了广泛的应用,包括诊断,治疗,病人监护,药物开发,和流行病学调查。这显著增强了医疗信息系统并且促进了医疗数据的互操作性。
    在我们的研究中,我们分析了4540名患者的电子健康记录的纵向数据,来自深圳国家传染病临床研究中心,中国,从2017年到2021年。最初,我们使用微调的ChatGLM构建电子病历.随后,我们利用多层感知器对每位患者进行分类,并确定HIV患者是否存在结核.使用基于机器学习的自然语言处理,我们对这些记录进行了结构化,以建立针对HIV和TB合并感染的专门数据库。我们研究了流行病学特征,专注于发病模式,患者特征,和影响因素,揭示这些疾病在深圳的传播特征。此外,我们使用长短期记忆来创建HIV患者结核病合并感染的预测模型,根据他们的医疗记录.该模型预测了结核病合并感染的风险,为临床决策提供科学依据,实现早期发现和精确干预。
    基于为结构化电子健康记录量身定制的精细ChatGLM模型,症状提取的准确性始终超过0.95精度。腹泻和正常等主要症状的准确率超过0.90。在召回和F1得分方面也取得了高分。在4540名HIV患者中,758人被诊断为并发结核病,表明合并感染率为16.7%,而梅毒合并感染占25.1%,强调HIV患者并发感染的患病率。利用电子健康记录,开发了多层感知器分类器作为长期短期记忆的基准,以预测HIV和结核病合并感染的高危人群。多层感知器分类器在测试集上显示出AUROC值范围为0.616至0.682的预测能力,尽管它在识别HIV-TB合并感染方面具有准确性,但仍有进一步优化和推广的机会。在基于实验室结果的结核病智能诊断中,长短期记忆在5倍交叉验证中表现一致,AUROC值范围为0.827~0.850,表明结核病预测的可靠性和一致性。此外,通过优化分类阈值,该模型在区分HIV合并感染的结核病和单纯HIV感染方面的总体准确率为81.18%.
    将多层感知器分类器与长短期记忆相结合,是一种有效提取电子健康记录并将其用于疾病预测的先进方法。这突显了深度学习技术在管理结构化和非结构化医疗数据方面的卓越表现。与仅依靠电子健康记录预测结核病发病率的模型相比,利用实验室时间序列数据的模型表现出明显更好的性能。这强调了深度学习在处理复杂医疗数据方面的好处,并为医疗保健提供者探索深度学习在疾病预测和管理中的应用提供了有价值的见解。
    UNASSIGNED: Both HIV and TB are chronic infectious diseases requiring long-term treatment and follow-up, resulting in extensive electronic medical records. With the exponential growth of health and medical big data, effectively extracting and analyzing these data has become the research hotspot. As a fundamental aspect of artificial intelligence, machine learning has been extensively applied in medical research, encompassing diagnosis, treatment, patient monitoring, drug development, and epidemiological investigations. This significantly enhances medical information systems and facilitates the interoperability of medical data.
    UNASSIGNED: In our study, we analyzed longitudinal data from the electronic health records of 4540 patients, gathered from the National Clinical Research Center for Infectious Diseases in Shenzhen, China, spanning from 2017 to 2021. Initially, we employed the fine-tuned ChatGLM to structure the electronic medical records. Subsequently, we utilized a multi-layer perceptron to classify each patient and determined the presence of tuberculosis in HIV patients. Using machine learning-based natural language processing, we structured these records to build a specialized database for HIV and TB co-infection. We studied the epidemiological characteristics, focusing on incidence patterns, patient characteristics, and influencing factors, to uncover the transmission characteristics of these diseases in Shenzhen. Additionally, we used Long Short-Term Memory to create a predictive model for TB co-infection among HIV patients, based on their medical records. This model predicted the risk of TB co-infection, providing scientific evidence for clinical decision-making and enabling early detection and precise intervention.
    UNASSIGNED: Based on the refined ChatGLM model tailored for structured electronic health records, the accuracy of symptom extraction consistently surpassed 0.95 precision. Key symptoms such as diarrhea and normal showed precision rates exceeding 0.90. High scores were also achieved in recall and F1 scores. Among 4540 HIV patients, 758 were diagnosed with concurrent tuberculosis, indicating a 16.7% co-infection rate, while syphilis co-infection affected 25.1%, underscoring the prevalence of concurrent infections among HIV patients. Utilizing electronic health records, a Multilayer Perceptron classifier was developed as a benchmark against Long Short-Term Memory to predict high-risk groups for HIV and tuberculosis co-infections. The Multilayer Perceptron classifier demonstrated predictive ability with AUROC values ranging from 0.616 to 0.682 on the test set, suggesting opportunities for further optimization and generalization despite its accuracy in identifying HIV-TB co-infections. In tuberculosis intelligent diagnosis based on laboratory results, the Long Short-Term Memory showed consistent performance across 5-fold cross-validation, with AUROC values ranging from 0.827 to 0.850, indicating reliability and consistency in tuberculosis prediction. Furthermore, by optimizing classification thresholds, the model achieved an overall accuracy of 81.18% in distinguishing HIV co-infected tuberculosis from simple HIV infection.
    UNASSIGNED: Combining the Multilayer Perceptron classifier with Long Short-Term Memory represented an advanced approach for effectively extracting electronic health records and utilizing it for disease prediction. This underscored the superior performance of deep learning techniques in managing both structured and unstructured medical data. Models leveraging laboratory time-series data demonstrated notably better performance compared to those relying solely on electronic health records for predicting tuberculosis incidence. This emphasized the benefits of deep learning in handling intricate medical data and provided valuable insights for healthcare providers exploring the use of deep learning in disease prediction and management.
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  • 文章类型: Journal Article
    越来越多,信息技术促进了对风险分析和事件预测有用的数据的存储和管理。与职业健康和安全相关的数据提取研究越来越多;然而,由于其可变性,建筑业值得特别关注。这项审查是在国家职业意外保险研究所(Inail)的研究计划下进行的。
    目标:研究问题的重点是确定哪些数据挖掘(DM)方法,在监督中,无人监督,和其他人,最适合某些调查目标,类型,和数据来源,由作者定义。
    方法:Scopus和ProQuest是我们提取建筑领域研究的主要来源,2014年至2023年出版。选择研究的资格标准基于系统评价和荟萃分析的首选报告项目(PRISMA)。出于探索目的,我们应用了层次聚类,而为了深入分析,我们使用主成分分析(PCA)和荟萃分析。
    结果:基于PRISMA资格标准的搜索策略为我们提供了2234篇潜在文章中的63篇,206项意见,89种方法,4调查目的,3个数据源,7种数据类型,和3种资源类型。聚类分析和PCA将论文数据集中的信息分为两个维度和标签:“监督方法,机构数据集,以及预测和分类目的“(相关性0.97-8.18×10-1;p值7.67×10-55-1.28×10-22)和第二个,Dim2“非监督方法;项目,模拟,文学,文本数据;监控,决策过程;机械与环境\“(Corr.0.84-0.47;p值5.79×10-25-3.59×10-6)。我们回答了关于哪种方法的研究问题,在监督中,无人监督,或其他,最适合应用于建筑行业的数据。
    结论:荟萃分析提供了监督方法(赔率比=0.71,置信区间0.53-0.96)比非监督方法更好的有效性的总体估计。
    Increasingly, information technology facilitates the storage and management of data useful for risk analysis and event prediction. Studies on data extraction related to occupational health and safety are increasingly available; however, due to its variability, the construction sector warrants special attention. This review is conducted under the research programs of the National Institute for Occupational Accident Insurance (Inail).
    OBJECTIVE: The research question focuses on identifying which data mining (DM) methods, among supervised, unsupervised, and others, are most appropriate for certain investigation objectives, types, and sources of data, as defined by the authors.
    METHODS: Scopus and ProQuest were the main sources from which we extracted studies in the field of construction, published between 2014 and 2023. The eligibility criteria applied in the selection of studies were based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). For exploratory purposes, we applied hierarchical clustering, while for in-depth analysis, we used principal component analysis (PCA) and meta-analysis.
    RESULTS: The search strategy based on the PRISMA eligibility criteria provided us with 63 out of 2234 potential articles, 206 observations, 89 methodologies, 4 survey purposes, 3 data sources, 7 data types, and 3 resource types. Cluster analysis and PCA organized the information included in the paper dataset into two dimensions and labels: \"supervised methods, institutional dataset, and predictive and classificatory purposes\" (correlation 0.97-8.18 × 10-1; p-value 7.67 × 10-55-1.28 × 10-22) and the second, Dim2 \"not-supervised methods; project, simulation, literature, text data; monitoring, decision-making processes; machinery and environment\" (corr. 0.84-0.47; p-value 5.79 × 10-25--3.59 × 10-6). We answered the research question regarding which method, among supervised, unsupervised, or other, is most suitable for application to data in the construction industry.
    CONCLUSIONS: The meta-analysis provided an overall estimate of the better effectiveness of supervised methods (Odds Ratio = 0.71, Confidence Interval 0.53-0.96) compared to not-supervised methods.
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  • 文章类型: Journal Article
    高通量测序技术的广泛使用彻底改变了对生物学和癌症异质性的理解。最近,已经开发了几种基于转录数据的机器学习模型来准确预测患者的预后和临床反应。然而,一个开源的R包,涵盖了最先进的机器学习算法,用于用户友好的访问尚未开发。因此,我们提出了一个灵活的计算框架来构建一个基于机器学习的集成模型,具有优雅的性能(Mime)。Mime简化了高精度预测模型的开发过程,利用复杂的数据集来识别与预后相关的关键基因。与其他已发表的模型相比,由Mime构建的基于从头PIEZO1相关签名的计算机组合模型在预测患者结局方面具有很高的准确性。此外,通过在Mime中应用不同算法,PIEZO1相关特征也可以精确推断免疫治疗反应.最后,选自PIEZO1相关特征的SDC1表现出作为神经胶质瘤靶标的高潜力。一起来看,我们的软件包为构建基于机器学习的集成模型提供了用户友好的解决方案,并将大大扩展以提供对当前领域的宝贵见解。Mime软件包可在GitHub(https://github.com/l-magnumeration/Mime)上找到。
    The widespread use of high-throughput sequencing technologies has revolutionized the understanding of biology and cancer heterogeneity. Recently, several machine-learning models based on transcriptional data have been developed to accurately predict patients\' outcome and clinical response. However, an open-source R package covering state-of-the-art machine-learning algorithms for user-friendly access has yet to be developed. Thus, we proposed a flexible computational framework to construct a machine learning-based integration model with elegant performance (Mime). Mime streamlines the process of developing predictive models with high accuracy, leveraging complex datasets to identify critical genes associated with prognosis. An in silico combined model based on de novo PIEZO1-associated signatures constructed by Mime demonstrated high accuracy in predicting the outcomes of patients compared with other published models. Furthermore, the PIEZO1-associated signatures could also precisely infer immunotherapy response by applying different algorithms in Mime. Finally, SDC1 selected from the PIEZO1-associated signatures demonstrated high potential as a glioma target. Taken together, our package provides a user-friendly solution for constructing machine learning-based integration models and will be greatly expanded to provide valuable insights into current fields. The Mime package is available on GitHub (https://github.com/l-magnificence/Mime).
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  • 文章类型: Journal Article
    使用快速粘度分析仪测定高质量木薯粉的糊化性质是昂贵且耗时的。使用移动近红外光谱(SCiO™)是一种替代的高通量表型技术,用于预测高质量木薯粉性状的糊化特性。然而,模型的开发和验证是必要的,以验证合理的期望建立了一个预测模型的准确性。在持续繁殖的背景下,我们调查了一种廉价的,便携式光谱仪,只记录整个近红外光谱的一部分(740-1070nm)来预测木薯粘贴特性。三种机器学习模型,即glmnet,lm,和GBM,在R统计程序的Caret包中实现,被单独评估。根据校准统计(R2、RMSE和MAE),我们发现使用glmnet的模型校准提供了分解粘度的最佳模型,峰值粘度和糊化温度。使用一阶导数的glmnet模型,峰值粘度的校准精度和验证精度分别为R2=0.56和R2=0.51,而细分粘度的校准精度和验证精度分别为R2=0.66和R2=0.66.我们还发现,用移动平均线叠加预处理,SavitzkyGolay,一阶导数,使用glmnet模型的二阶导数和标准正态变量导致粘贴温度的校准和验证精度分别为R2=0.65和R2=0.64。开发的校准模型预测HQCF的粘贴特性,具有足够的准确性,可用于筛选目的。因此,SCiO™可以可靠地用于筛选早期育种材料的粘贴特性。
    Determination of pasting properties of high quality cassava flour using rapid visco analyzer is expensive and time consuming. The use of mobile near infrared spectroscopy (SCiO™) is an alternative high throughput phenotyping technology for predicting pasting properties of high quality cassava flour traits. However, model development and validation are necessary to verify that reasonable expectations are established for the accuracy of a prediction model. In the context of an ongoing breeding effort, we investigated the use of an inexpensive, portable spectrometer that only records a portion (740-1070 nm) of the whole NIR spectrum to predict cassava pasting properties. Three machine-learning models, namely glmnet, lm, and gbm, implemented in the Caret package in R statistical program, were solely evaluated. Based on calibration statistics (R2, RMSE and MAE), we found that model calibrations using glmnet provided the best model for breakdown viscosity, peak viscosity and pasting temperature. The glmnet model using the first derivative, peak viscosity had calibration and validation accuracy of R2 = 0.56 and R2 = 0.51 respectively while breakdown had calibration and validation accuracy of R2 = 0.66 and R2 = 0.66 respectively. We also found out that stacking of pre-treatments with Moving Average, Savitzky Golay, First Derivative, Second derivative and Standard Normal variate using glmnet model resulted in calibration and validation accuracy of R2 = 0.65 and R2 = 0.64 respectively for pasting temperature. The developed calibration model predicted the pasting properties of HQCF with sufficient accuracy for screening purposes. Therefore, SCiO™ can be reliably deployed in screening early-generation breeding materials for pasting properties.
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  • 文章类型: Journal Article
    本研究旨在使用概念框架开发ICU死亡率预测模型,关注反映在MIMICIV数据库护理记录中的护士关注问题。我们包括46,693名18岁以上成年人的首次ICU入院,至少24小时逗留,不包括那些接受临终关怀或姑息治疗的人。预测因素包括人口统计,临床特征,和与护士相关的护理文件频率。在调整类失衡后,对四个模型进行了10倍交叉验证训练。随机森林(RF)模型被认为是表现最好的,在这个模型中,死亡率的关键预测因素是生命体征的频率,护理笔记文档的频率,以及与监测相关的护理记录的频率。这表明使用护理记录的预测模型,这反映了护士的担忧,表现为护理文件的频率,可以集成到临床决策支持工具中,有可能提高ICU患者的预后。
    This study aimed to develop ICU mortality prediction models using a conceptual framework, focusing on nurses\' concerns reflected in nursing records from the MIMIC IV database. We included 46,693 first-time ICU admissions of adults over 18 years with a minimum 24-hour stay, excluding those receiving hospice or palliative care. Predictors included demographics, clinical characteristics, and nursing documentation frequencies related to nurses\' concerns. Four models were trained with 10-fold cross-validation after adjusting class imbalance. The random forest (RF) model was identified as the best-performing, with key predictors of mortality in this model being the frequency of vital signs, the frequency of nursing note documentation, and the frequency of monitoring-related nursing notes. This suggests that predictive models using nursing records, which reflect nurses\' concerns as represented by the frequency of nursing documentation, may be integrated into clinical decision support tools, potentially enhancing patient outcomes in ICUs.
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  • 文章类型: Journal Article
    目标:训练,测试和外部验证一个预测模型,该模型支持全科医生(GP)早期识别存在持续超过一年的症状诊断风险的患者。
    方法:我们从家庭医学网(FaMe-Net)数据库中回顾性收集并选择了2008年至2021年期间出现症状诊断发作的所有患者。从这个群体中,我们确定了持续不到1年的症状诊断和持续超过1年的症状诊断.使用反向选择的多变量逻辑回归分析用于评估哪些因素对持续超过一年的症状诊断最具预测性。使用校准和鉴别(AUC)测量来评估模型的性能。使用AHON注册中心2018年至2022年之间的数据对外部验证进行了测试,初级保健电子健康记录数据登记处,包括来自荷兰北部和东部地区的73例一般诊所和约460,795例患者.
    结果:从FaMe-Net注册表中纳入的47,870例症状诊断患者中,12,481(26.1%)的症状诊断持续了一年以上。年龄较大(≥75岁:OR=1.30,95%CI[1.19,1.42]),既往症状诊断较多(≥3:1.11,[1.05,1.17])和过去2年与全科医生接触较多(≥10次接触:5.32,[4.80,5.89])可预测持续超过1年的症状诊断,且区分度基本可接受(AUC0.70,95%CI[0.69-0.70]).外部验证显示性能差,AUC为0.64([0.63-0.64])。
    结论:基于年龄的临床预测模型,以前的症状诊断和接触次数可能有助于全科医生早期识别出现持续超过一年的症状诊断的患者.然而,原始模型的性能是有限的。因此,该模型尚未准备好大规模实施。
    OBJECTIVE: To train, test and externally validate a prediction model that supports General Practitioners (GPs) in early identification of patients at risk of developing symptom diagnoses that persist for more than a year.
    METHODS: We retrospectively collected and selected all patients having episodes of symptom diagnoses during the period 2008 and 2021 from the Family Medicine Network (FaMe-Net) database. From this group, we identified symptom diagnoses that last for less than a year and symptom diagnoses that persist for more than a year. Multivariable logistic regression analysis using a backward selection was used to assess which factors were most predictive for developing symptom diagnoses that persist for more than a year. Performance of the model was assessed using calibration and discrimination (AUC) measures. External validation was tested using data between 2018 and 2022 from AHON-registry, a primary care electronic health records data registry including 73 general practices from the north and east regions of the Netherlands and about 460,795 patients.
    RESULTS: From the included 47,870 patients with a symptom diagnosis in the FaMe-Net registry, 12,481 (26.1%) had a symptom diagnosis that persisted for more than a year. Older age (≥ 75 years: OR = 1.30, 95% CI [1.19, 1.42]), having more previous symptom diagnoses (≥ 3: 1.11, [1.05, 1.17]) and more contacts with the GP over the last 2 years (≥ 10 contacts: 5.32, [4.80, 5.89]) were predictive of symptom diagnoses that persist for more than a year with a marginally acceptable discrimination (AUC 0.70, 95% CI [0.69-0.70]). The external validation showed poor performance with an AUC of 0.64 ([0.63-0.64]).
    CONCLUSIONS: A clinical prediction model based on age, number of previous symptom diagnoses and contacts might help the GP to early identify patients developing symptom diagnoses that persist for more than a year. However, the performance of the original model is limited. Hence, the model is not yet ready for a large-scale implementation.
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  • 文章类型: Journal Article
    脑瘫(CP)是一种常见的运动障碍,起源于早期脑损伤或畸形,在临床表现和病因上有显著的变异性。缺乏可靠的生物标志物阻碍了早期诊断和个性化治疗干预。这项研究旨在确定脑瘫的潜在生物标志物,并开发预测模型以增强早期诊断和预后。我们对CP患者肌肉样本中的基因表达谱进行了全面的生物信息学分析,以确定候选生物标志物。六个关键基因(CKMT2,TNNT2,MYH4,MYH1,GOT1和LPL)在一个独立的队列中进行了验证,并对CP发病机制中潜在的生物学通路和分子网络进行分析。功能调节等过程的重要性,能量代谢,强调了CP患者肌肉中的细胞信号传导途径。开发并可视化与CP相关的肌肉样品生物标志物的预测模型。校准曲线和受试者工作特性分析表明,预测模型在区分CP风险个体方面表现出高灵敏度和特异性。识别的生物标志物和开发的预测模型为CP的早期诊断和个性化管理提供了巨大的潜力。未来的研究应该集中在更大的队列中验证这些生物标志物,并将它们整合到临床实践中,以改善CP患者的预后。
    Cerebral palsy (CP) is a prevalent motor disorder originating from early brain injury or malformation, with significant variability in its clinical presentation and etiology. Early diagnosis and personalized therapeutic interventions are hindered by the lack of reliable biomarkers. This study aims to identify potential biomarkers for cerebral palsy and develop predictive models to enhance early diagnosis and prognosis. We conducted a comprehensive bioinformatics analysis of gene expression profiles in muscle samples from CP patients to identify candidate biomarkers. Six key genes (CKMT2, TNNT2, MYH4, MYH1, GOT1, and LPL) were validated in an independent cohort, and potential biological pathways and molecular networks involved in CP pathogenesis were analyzed. The importance of processes such as functional regulation, energy metabolism, and cell signaling pathways in the muscles of CP patients was emphasized. Predictive models of muscle sample biomarkers related to CP were developed and visualized. Calibration curves and receiver operating characteristic analysis demonstrated that the predictive models exhibit high sensitivity and specificity in distinguishing individuals at risk of CP. The identified biomarkers and developed prediction models offer significant potential for early diagnosis and personalized management of CP. Future research should focus on validating these biomarkers in larger cohorts and integrating them into clinical practice to improve outcomes for individuals with CP.
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