Capsiate(CAP)是一种非刺激性辣椒素类似物(CapsicumannuumL.提取物),已被研究为潜在的抗肥胖药。然而,慢性CAP补充与抗阻训练之间的相互作用尚不清楚。这项研究的目的是检查脂肪组织来源的激素的变化,身体成分,食欲,抗阻训练10周后的肌肉力量,结合健康未经训练的男性的慢性CAP补充。我们假设,与单独的阻力训练相比,CAP在干预10周后与阻力训练相结合可以产生更高的益处。二十四个年轻人(年龄,22.0±2.9)被随机分配给辣椒素补充剂(CAP=12mg/天)或安慰剂(PL),两组均进行阻力训练.身体成分,瘦素和脂联素浓度,主观的食欲评价,能量摄入,在进行10周的渐进性阻力训练之前和之后评估运动表现。体重显著增加(P<0.001),无脂质量(CAP:58.0±7.1vs.post,59.7±7.1kg;PL:预,58.4±7.3vs.post,59.8±7.1kg;P<.001),静息代谢率(CAP:前,1782.9±160.6vs.post,1796.3±162.0千卡;PL:预,1733.0±148.9vs.post,1750.5±149.8千卡;P<.001),两组在45腿按压(P<.001)和卧推(P<.001)时的最大强度,但没有显著(P>0.05)补充训练期间的相互作用,也没有观察到脂肪量。对于食欲的主观评级,能量摄入,瘦素,和脂联素,没有观察到训练期交互作用的显着影响(P>.05)。总之,10周的阻力训练增加了总体重,肌肉质量,和最大的力量在健康的未经训练的男人;然而,CAP补充剂(12毫克,每周7天)未能改变脂肪组织来源的激素,食欲,这个人群的身体成分和肌肉力量。根据巴西临床试验注册中心(RBR-8cz9kfq)注册。
Capsiate (CAP) is a nonpungent capsaicin analog (Capsicum annuum L. extract) that has been studied as a potential antiobesity agent. However, the interaction between chronic CAP supplementation and resistance training is not clear. The purpose of this study was to examine the changes in adipose tissue-derived hormones, body composition, appetite, and muscle strength after 10 weeks of resistance training, combined with chronic CAP supplementation in healthy untrained men. We hypothesized that CAP could induce higher benefits when combined with resistance training after 10 weeks of intervention compared to resistance training alone. Twenty-four young men (age, 22.0 ± 2.9) were randomized to either capsiate supplementation (CAP = 12 mg/day) or placebo (PL), and both groups were assigned to resistance training. Body composition, leptin and adiponectin concentrations, subjective ratings of appetite, energy intake, and exercise performance were assessed at before and after 10 weeks of progressive resistance training. There was a significant increase in body mass (P < .001), fat-free mass (CAP: 58.0 ± 7.1 vs. post, 59.7 ± 7.1 kg; PL: pre, 58.4 ± 7.3 vs. post, 59.8 ± 7.1 kg; P < .001), resting metabolic rate (CAP: pre, 1782.9 ± 160.6 vs. post, 1796.3 ± 162.0 kcal; PL: pre, 1733.0 ± 148.9 vs. post, 1750.5 ± 149.8 kcal; P < .001), maximal strength at 45 leg press (P < .001) and bench press (P < .001) in both groups, but no significant (P > .05) supplementation by training period interaction nor fat mass was observed. For subjective ratings of appetite, energy intake, leptin, and adiponectin, no significant effect of supplementation by training period interaction was observed (P > .05). In conclusion, 10 weeks of resistance training increased total body weight, muscle mass, and maximum strength in healthy untrained men; however, CAP supplementation (12 mg, 7 days per week) failed to change adipose tissue-derived hormones, appetite, body composition and muscle strength in this population. Registered under Brazilian Registry of Clinical Trials (RBR-8cz9kfq).