postpartum health

产后健康
  • 文章类型: Journal Article
    背景:与接收国的妇女相比,移民妇女是一个异质性群体,其妊娠并发症和不良分娩结局的风险较高和较低。本研究旨在调查妇女产后使用瑞典医疗保健的情况,住院时间>48小时,再次入院,和专门的门诊就诊,关于母亲的出生国。
    方法:一项基于人群的登记研究,包括瑞典278219名初产妇和367776名多胎妇女(2014-2019年),使用瑞典妊娠登记册的数据,瑞典国家患者登记和统计。多变量逻辑回归分析用于估计产妇出生国和结局之间的关联,调整出生年份,产妇年龄,教育,孕前高血压和糖尿病,和医疗保健地区,以瑞典出生女性为参考,以95%置信区间(CI)表示为粗比值比和调整后比值比(aOR)。
    结果:移民妇女亚组产后住院时间>48小时的几率更高,尤其是来自厄立特里亚的妇女(初产AOR2.80,CI2.49-3.15;多产AOR2.78,CI2.59-2.98),索马里(初产aOR2.61,CI2.34-2.92;多产aOR1.87,CI1.79-1.97),和印度(初产AOR2.52,CI2.14-2.97;多产AOR2.61,CI2.33-2.93),与瑞典出生的女性相比。来自阿富汗的初产妇(aOR1.32,CI1.08-1.6),伊拉克(aOR1.30,CI1.16-1.46),伊朗(aOR1.23,CI1.04-1.45)再次入院的几率略高,以及来自印度(aOR1.34,CI1.02-1.76)和索马里(aOR1.24,CI1.11-1.38)的多产妇女。专业门诊就诊最常见于索马里初产妇(aOR1.47,CI1.35-1.59),伊朗(aOR1.31,CI1.22-1.42)和阿富汗(aOR1.31,CI1.18-1.46),在伊朗(aOR1.30,CI1.20-1.41)和伊拉克(aOR1.15,CI1.11-1.20)的多产妇女中,然而在其他一些国家的女性中却不那么常见。
    结论:妇女在产后期间瑞典医疗保健的使用各不相同,这取决于他们的出生国家。来自某些国家的妇女产后住院时间超过48小时的几率特别高,与瑞典出生的女性相比,不管胎次和孕前医学疾病。需要进一步的研究来确定在产后期间移民妇女的个人需求是否得到满足。
    BACKGROUND: Migrant women are a heterogenous group with both higher and lower risk for pregnancy complications and adverse birth outcomes compared with women in the receiving countries. This study aimed to investigate women\'s use of Swedish healthcare postpartum, in terms of hospital stay >48 h, readmission to hospital, and specialized out-patient clinic visits, in relation to maternal country of birth.
    METHODS: A population-based register study including 278 219 primiparous and 367 776 multiparous women in Sweden (2014-2019) using data from Swedish Pregnancy Register, National Patient Register and Statistics Sweden. Multivariable logistic regression analyses were used to estimate associations between maternal country of birth and outcomes, adjusting for year of birth, maternal age, education, pre-gestational hypertension and diabetes, and healthcare region, presented as crude and adjusted odds ratios (aOR) with 95% confidence interval (CI) with Swedish-born women as reference.
    RESULTS: Subgroups of migrant women had higher odds of postpartum hospital stays > 48 h, particularly women from Eritrea (primiparous aOR 2.80, CI 2.49-3.15; multiparous aOR 2.78, CI 2.59-2.98), Somalia (primiparous aOR 2.61, CI 2.34-2.92; multiparous aOR 1.87, CI 1.79-1.97), and India (primiparous aOR 2.52, CI 2.14-2.97; multiparous aOR 2.61, CI 2.33-2.93), compared to Swedish-born women. Primiparous women from Afghanistan (aOR 1.32, CI 1.08-1.6), Iraq (aOR 1.30, CI 1.16-1.46), and Iran (aOR 1.23, CI 1.04-1.45) had slightly higher odds of hospital readmission, along with multiparous women from India (aOR 1.34, CI 1.02-1.76) and Somalia (aOR 1.24, CI 1.11-1.38). Specialized out-patient clinic visits were most common in primiparous women from Somalia (aOR 1.47, CI 1.35-1.59), Iran (aOR 1.31, CI 1.22-1.42) and Afghanistan (aOR 1.31, CI 1.18-1.46), and in multiparous women from Iran (aOR 1.30, CI 1.20-1.41) and Iraq (aOR 1.15, CI 1.11-1.20), however less common in women from some other countries.
    CONCLUSIONS: The use of Swedish health care during the postpartum period varied among women, depending on their country of birth. Women from certain countries had particularly high odds of postpartum hospital stays exceeding 48 h, compared to Swedish-born women, regardless of parity and pre-gestational medical disorders. Further studies are needed to determine whether the individual needs of migrant women are being met during the postpartum period or not.
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  • 文章类型: Journal Article
    目的:患有GDM的女性表现出不良的终生心脏代谢健康。我们研究了GDM患者早期二甲双胍是否会影响产后心脏代谢危险因素。
    方法:紧急,双盲,安慰剂对照试验在GDM诊断时将1:1妊娠随机分配至安慰剂或二甲双胍,并从随机分组至产后12±4周随访参与者.总共有478次怀孕可用于产后产妇评估,237和241分别分配给二甲双胍和安慰剂。重量(kg),体重指数(BMI)(kg/m2),测量腰围(cm)和血压(mmHg),记录婴儿喂养方法并抽取血液进行75克口服葡萄糖耐量试验,空腹胰岛素,C肽和脂质分析。
    结果:尽管随机试验时体重和BMI相似,接受二甲双胍治疗的参与者在产后访视时的体重(79.5±15.9vs82.6±16.9kg;p=0.04)和BMI(29.3(5.6)vs30.5(5.4);p=0.018)显著降低.然而,二甲双胍组和安慰剂组之间从随机化到产后12周的体重变化没有差异。总体29%(n=139)的队列符合糖尿病前期或糖尿病的标准,与二甲双胍没有积极的影响。胰岛素抵抗的测量也没有差异,组间的血压或血脂。
    结论:GDM患者早期使用二甲双胍对产后早期重要的心脏代谢参数没有影响,尽管在孕期体重增加和胰岛素使用方面有显著益处。
    OBJECTIVE: Women with GDM display adverse lifetime cardio-metabolic health. We examined whether early metformin in GDM could impact cardio-metabolic risk factors postpartum.
    METHODS: EMERGE, a double-blind, placebo-controlled trial randomized pregnancies 1:1 to placebo or metformin at GDM diagnosis and followed participants from randomization until 12±4 weeks postpartum. In total 478 pregnancies were available for postpartum maternal assessment, 237 and 241 assigned to metformin and placebo respectively. Weight (kg), body mass index (BMI) (kg/m2), waist circumference (cm) and blood pressure (mmHg) were measured, infant feeding method documented and bloods drawn for a 75 gram oral glucose tolerance test, fasting insulin, C peptide and lipid analysis.
    RESULTS: Despite similar weight and BMI at trial randomization, participants receiving metformin had significantly lower weight (79.5±15.9 vs 82.6±16.9kg; p=0.04) and BMI (29.3(5.6) vs 30.5(5.4); p=0.018) at the postpartum visit. However no difference in weight change from randomisation to 12 weeks postpartum was observed between metformin and placebo groups. Overall 29% (n=139) of the cohort met criteria for prediabetes or diabetes, with no positive impact with metformin. There were also no differences in measurements of insulin resistance, blood pressure or lipids between groups.
    CONCLUSIONS: Early metformin use in GDM did not impact important cardio-metabolic parameters in the early postpartum period despite significant benefits in weight gain and insulin use in pregnancy.
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  • 文章类型: Journal Article
    在美国,孕产妇健康不平等不成比例地影响全球多数(例如,亚洲人,黑色,和西班牙裔)人口。尽管大量研究强调了种族主义对这些不平等的影响,很少有研究研究怀孕和分娩期间性别种族微侵略的经历如何影响产科医院环境中种族和种族多样性的全球大多数孕妇和分娩者。我们评估了刘易斯和内维尔的性别种族微侵略量表的改编版本的心理测量特性,使用从417名全球多数分娩者收集的数据。我们研究的结果表明,我们改编的GRMS是评估全球多数孕妇和分娩者在医院产科护理环境中性别种族微侵害经历的有效工具,这些人的首选语言是英语或西班牙语。项目反应理论(IRT)分析证明了适应的GRMS量表的高结构效度(近似均方根误差=0.1089(95%CI0.0921,0.1263),比较拟合指数=0.977,标准化均方根残差=0.075,对数似然c2=-85.6,df=8)。IRT分析表明,一维模型比二维模型更易于解释,AIC和BIC较低,所有项目在单个因素上都有较大的判别参数(所有判别参数>3.0)。鉴于我们在黑人和西班牙裔受访者中发现了相似的反应特征,我们的差异项目功能分析支持Black,西班牙裔,和讲西班牙语的分娩者。项目间相关性证明了足够的量表可靠性,α=0.97,经验可靠性=0.67。Pearsons相关性用于评估我们的适应量表的标准有效性。我们的量表总分与产后抑郁和焦虑呈显著正相关。研究人员和从业人员应设法解决产科环境中性别种族微侵害的情况,因为它们是系统和人际种族主义的表现,影响产后健康。
    In the United States, maternal health inequities disproportionately affect Global Majority (e.g., Asian, Black, and Hispanic) populations. Despite a substantial body of research underscoring the influence of racism on these inequities, little research has examined how experiences of gendered racial microaggressions during pregnancy and birth impact racially and ethnically diverse Global Majority pregnant and birthing people in obstetric hospital settings. We evaluated the psychometric properties of an adapted version of Lewis & Neville\'s Gendered Racial Microaggressions Scale, using data collected from 417 Global Majority birthing people. Findings from our study indicate that our adapted GRMS is a valid tool for assessing the experiences of gendered racial microaggressions in hospital-based obstetric care settings among Global Majority pregnant and birthing people whose preferred languages are English or Spanish. Item Response Theory (IRT) analysis demonstrated high construct validity of the adapted GRMS scale (Root Mean Square Error of Approximation = 0.1089 (95% CI 0.0921, 0.1263), Comparative Fit Index = 0.977, Standardized Root Mean Square Residual = 0.075, log-likelihood c2 = -85.6, df = 8). IRT analyses demonstrated that the unidimensional model was preferred to the bi-dimensional model as it was more interpretable, had lower AIC and BIC, and all items had large discrimination parameters onto a single factor (all discrimination parameters > 3.0). Given that we found similar response profiles among Black and Hispanic respondents, our Differential Item Functioning analyses support validity among Black, Hispanic, and Spanish-speaking birthing people. Inter-item correlations demonstrated adequate scale reliability, α = 0.97, and empirical reliability = 0.67. Pearsons correlations was used to assess the criterion validity of our adapted scale. Our scale\'s total score was significantly and positively related to postpartum depression and anxiety. Researchers and practitioners should seek to address instances of gendered racial microaggressions in obstetric settings, as they are manifestations of systemic and interpersonal racism, and impact postpartum health.
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  • 文章类型: Journal Article
    产后对分娩者的健康和福祉至关重要,然而,人们对这段时间所需的医疗保健服务和支持的范围知之甚少。产妇护理患者通常根据“低风险”或“高风险”名称进行临床干预,但是二分法的措施可能不精确,可能无法反映有意义的群体对理解所需的产后护理。使用2016年至2018年间私人保险分娩患者的索赔数据,本研究确定了产后护理利用的类别和预测因素。包括使用产妇护理和其他,非母性,护理(例如,呼吸,消化)。然后,我们将确定的基于利用率的类别与典型的高风险和低风险名称进行比较。在269992名患者中,确定了5类:(1)低使用率(55%的分娩);(2)中度使用产妇护理,其他护理使用率低(25%);(3)中度产妇,其他高(8%);(4)高产妇,中度其他(7%);和(5)高产妇,其他高(5%)。基于利用的类别在区分产后护理使用方面更好,并且在患者概况中更加一致。与高风险和低风险二分法相比。除了简单的风险二分法之外,确定产后护理需求的类别是必要的,可以帮助孕产妇保健服务研究。决策,和临床实践。
    分娩后的时间对刚刚分娩的父母的健康很重要,产后的经验和需求差异很大。我们研究了分娩的私人被保险人的医疗保健数据,并确定了产后5种医疗保健用途。我们发现的类别都不适合产后6周一次就诊的常见模式,因为产后需要或使用的唯一护理。通常,患者分为高危人群和低危人群,但我们的研究表明,这是不够的,掩盖了这些二分法组中患者之间的重要差异。使用先进的统计方法来确定分娩后使用的医疗保健类别,可以通过更好地将资源用于最需要的人来改善产后健康。
    The postpartum period is critical for the health and well-being of birthing people, yet little is known about the range of health care services and supports needed during this time. Maternity care patients are often targeted for clinical interventions based on \"low risk\" or \"high risk\" designations, but dichotomized measures can be imprecise and may not reflect meaningful groups for understanding needed postpartum care. Using claims data from privately insured patients with childbirths between 2016 and 2018, this study identifies categories and predictors of postpartum care utilization, including the use of maternal care and other, nonmaternal, care (eg, respiratory, digestive). We then compare identified utilization-based categories with typical high- and low-risk designations. Among 269 992 patients, 5 categories were identified: (1) low use (55% of births); (2) moderate maternal care use, low other care use (25%); (3) moderate maternal, high other (8%); (4) high maternal, moderate other (7%); and (5) high maternal, high other (5%). Utilization-based categories were better at differentiating postpartum care use and were more consistent across patient profiles, compared with high- and low-risk dichotomies. Identifying categories of postpartum care need beyond a simple risk dichotomy is warranted and can assist in maternal health services research, policymaking, and clinical practice.
    The time after childbirth is important for the health of a parent who has just given birth, and postpartum experiences and needs vary widely. We studied health care data for privately insured people who gave birth and identified 5 categories of health care use in the postpartum period. None of the categories we uncovered fit the common model of a single visit at 6 weeks postpartum as the sole care needed or used postpartum. Typically, patients are divided into high-risk and low-risk groups, but our research shows that this is insufficient and masks important differences among patients within these dichotomous groups. Using advanced statistical methods to identify categories of health care use after childbirth may improve postpartum health by better targeting resources to those who need them the most.
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  • 文章类型: Journal Article
    我们使用152个商业奶牛场数据回顾性分析了干旱期长度(DPL)对牛奶产量和产后健康的影响,包括北海道46,228头奶牛,Japan,并检查了最佳DPL。DPL分为八类:≤25、26-35、36-45、46-55、56-65(参考),66-75、76-85和≥86d。DPL≤55d的奶牛的总产奶量(产奶前55d期间的产奶量和产奶后305d的产奶量之和)与参考组没有差异。DPL≤55d的奶牛移位皱胃(DA)的比值比(OR)较低,酮症,牛奶热(MF),乳脂蛋白比异常,但产褥热(PF)和死胎ORs高于参照组。在短DPL类别中,DPL为46-55d的奶牛的PF和死胎OR最低。与参考组相比,极短(≤25d)和长(≥86d)的DPL增加了乳腺炎的OR和体细胞计数(SCC)的异常衬里评分。我们得出的结论是,缩短DPL可以在不降低产奶量的情况下减少产后健康问题,并且最佳DPL为46-55d。
    We retrospectively analyzed the effects of dry period length (DPL) on milk yield and postpartum health using 152 commercial dairy farm data, including 46,228 dairy cows in Hokkaido, Japan, and examined the optimal DPL. The DPL was divided into eight categories: ≤25, 26-35, 36-45, 46-55, 56-65 (reference), 66-75, 76-85, and ≥86 d. The total milk yields (the sum of milk yield during the 55 d before and the 305 d milk yield after calving) of cows with DPL of ≤55 d did not differ from the reference group. Cows with DPL of ≤55 d had lower odds ratios (OR) of a displaced abomasum (DA), ketosis, milk fever (MF), and abnormal milk fat-to-protein ratio but had higher puerperal fever (PF) and stillbirth ORs than the reference group. Cows with a DPL of 46-55 d had the lowest PF and stillbirth ORs among the short DPL categories. The extremely short (≤25 d) and long (≥86 d) DPL increased the ORs of mastitis and abnormal liner score of somatic cell counts (SCCs) compared with the reference group. We conclude that shortening DPL can reduce postpartum health problems without reducing milk yield and that the optimal DPL is 46-55 d.
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  • 文章类型: Journal Article
    目的:产后尿失禁(UI)很常见;然而,大多数研究集中在产后早期,仅在一个或两个时间点评估患病率。我们假设UI在产后的前2年内会很普遍。我们的次要目标是评估全国代表性人群产后UI的危险因素,当代样本。
    方法:这个横截面,基于人群的研究使用了分娩后24个月内产妇的国家健康和营养检查调查(2011-2018)数据.UI的患病率,UI子类型,和严重程度进行了估计。多变量逻辑回归用于估计目标暴露的UI的调整后赔率(aOR)。
    结果:在560名产后妇女中,任何UI的患病率为43.5%.压力UI是最常见的(28.7%),大多数女性(82.8%)症状轻微。分娩后24个月内UI患病率无显著变化(R2=0.004)。产后UI患者往往年龄较大(30.3±0.5对28.8±0.5岁),BMI较高(31.1±0.6对28.9±0.6)。在多变量分析中,先前有阴道分娩的女性产后UI的几率更高(aOR2.0,95%CI:1.3-3.3),分娩前体重9磅(4公斤)或以上的婴儿(aOR2.5,95%CI:1.3-4.8),或报告当前吸烟的人(aOR1.5,95%CI:1.0-2.3)。
    结论:在产后前2年,43.5%的女性报告UI,在此期间患病率相对稳定。这种高患病率支持分娩后筛查UI,而不考虑风险因素。
    OBJECTIVE: Urinary incontinence (UI) is common in the postpartum period; however, most studies focus on the early postpartum period and assess prevalence at only one or two time points. We hypothesized that UI would be prevalent across the first 2 years postpartum. Our secondary objective was to evaluate risk factors for postpartum UI among a nationally representative, contemporary sample.
    METHODS: This cross-sectional, population-based study used National Health and Nutrition Examination Survey (2011-2018) data for parous women within 24 months following delivery. Prevalence of UI, UI subtypes, and severity were estimated. Multivariate logistic regression was used to estimate adjusted odds (aOR) of UI for exposures of interest.
    RESULTS: Among 560 postpartum women, prevalence of any UI was 43.5%. Stress UI was most common (28.7%), and most women (82.8%) experienced mild symptoms. There was no significant change in prevalence of UI across the 24 months following delivery (R2 = 0.004). Individuals with postpartum UI tended to be older (30.3 ± 0.5 versus 28.8 ± 0.5 years) and had higher BMI (31.1 ± 0.6 versus 28.9 ± 0.6). In multivariate analysis, odds of postpartum UI were higher for women who had had a prior vaginal delivery (aOR 2.0, 95% CI: 1.3-3.3), prior delivery of a baby weighing 9 lb (4 kg) or more (aOR 2.5, 95% CI: 1.3-4.8), or who reported current smoking (aOR 1.5, 95% CI: 1.0-2.3).
    CONCLUSIONS: During the first 2 years postpartum 43.5% of women report UI, with relatively stable prevalence over this period. This high prevalence supports screening for UI after delivery regardless of risk factors.
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  • 文章类型: Journal Article
    背景:尽管有大量关于产妇心理健康的证据,对非洲移民妇女的关注不够。鉴于加拿大人口结构的迅速变化,这是一个很大的限制。艾伯塔省和加拿大的非洲移民妇女中产妇抑郁和焦虑的患病率,以及相关的风险因素,没有得到很好的理解,并且在很大程度上仍然未知。
    目的:本研究的目的是调查生活在艾伯塔省的非洲移民妇女中母亲抑郁和焦虑的患病率和相关因素。加拿大产后长达2年。
    方法:这项横断面研究调查了艾伯塔省分娩后2年内的120名非洲移民妇女,加拿大从2020年1月到2020年12月。爱丁堡产后抑郁量表-10(EPDS-10)的英文版,广义焦虑症-7(GAD-7)量表,并对所有参与者进行了相关因素的结构化问卷.EPDS-10的13分表示抑郁,而GAD-7量表的截止分数为10分表示焦虑。采用多变量logistic回归分析与产妇抑郁和焦虑显著相关的因素。
    结果:在120名非洲移民妇女中,27.5%(33/120)符合EPDS-10抑郁的截止分数,12.1%(14/116)符合GAD-7焦虑的截止分数。大多数患有孕产妇抑郁症的受访者年轻(18/33,56%),家庭总收入为60,000加元或以上(45,000美元或以上;21/32,66%),租了他们的房子(24/33,73%),具有高级学位(19/33,58%),已婚(26/31,84%),是最近的移民(19/30,63%),在城市有朋友(21/31,68%),对当地社区的归属感较弱(26/31,84%),对他们的结算过程感到满意(17/28,61%),并获得了正规医生(20/29,69%)。此外,大多数母亲焦虑的受访者是非新移民(9/14,64%),在城市有朋友(8/13,62%),对当地社区的归属感较弱(12/13,92%),并获得了正规医生(7/12,58%)。多变量logistic回归模型确定了与孕产妇抑郁显著相关的人口统计学和社会因素(孕产妇年龄、工作状态,城市里的朋友们,和获得正规医生)和产妇焦虑(获得正规医生和当地社区的归属感)。
    结论:社会支持和社区归属感倡议可以改善非洲移民妇女的产妇心理健康结果。鉴于移民妇女面临的复杂性,需要对移民后孕产妇心理健康的公共卫生和预防策略的综合方法进行更多研究,包括增加家庭医生的机会。
    BACKGROUND: Although there is a significant body of evidence on maternal mental health, an inadequate focus has been placed on African immigrant women. This is a significant limitation given the rapidly changing demographics in Canada. The prevalence of maternal depression and anxiety among African immigrant women in Alberta and Canada, as well as the associated risk factors, are not well understood and remain largely unknown.
    OBJECTIVE: The purpose of this study was to investigate the prevalence and associated factors of maternal depression and anxiety among African immigrant women living in Alberta, Canada up to 2 years postpartum.
    METHODS: This cross-sectional study surveyed 120 African immigrant women within 2 years of delivery in Alberta, Canada from January 2020 to December 2020. The English version of the Edinburgh Postnatal Depression Scale-10 (EPDS-10), the Generalized Anxiety Disorder-7 (GAD-7) scale, and a structured questionnaire regarding associated factors were administered to all participants. A cutoff score of 13 on the EPDS-10 was indicative of depression, while a cutoff score of 10 on the GAD-7 scale was indicative of anxiety. Multivariable logistic regression was used to determine the factors significantly associated with maternal depression and anxiety.
    RESULTS: Among the 120 African immigrant women, 27.5% (33/120) met the EPDS-10 cutoff score for depression and 12.1% (14/116) met the GAD-7 cutoff score for anxiety. The majority of respondents with maternal depression were younger (18/33, 56%), had a total household income of CAD $60,000 or more (US $45,000 or more; 21/32, 66%), rented their homes (24/33, 73%), had an advanced degree (19/33, 58%), were married (26/31, 84%), were recent immigrants (19/30, 63%), had friends in the city (21/31, 68%), had a weak sense of belonging in the local community (26/31, 84%), were satisfied with their settlement process (17/28, 61%), and had access to a regular medical doctor (20/29, 69%). In addition, the majority of respondents with maternal anxiety were nonrecent immigrants (9/14, 64%), had friends in the city (8/13, 62%), had a weak sense of belonging in the local community (12/13, 92%), and had access to a regular medical doctor (7/12, 58%). The multivariable logistic regression model identified demographic and social factors significantly associated with maternal depression (maternal age, working status, presence of friends in the city, and access to a regular medical doctor) and maternal anxiety (access to a regular medical doctor and sense of belonging in the local community).
    CONCLUSIONS: Social support and community belonging initiatives may improve the maternal mental health outcomes of African immigrant women. Given the complexities immigrant women face, more research is needed on a comprehensive approach for public health and preventive strategies regarding maternal mental health after migration, including increasing access to family doctors.
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  • 文章类型: Randomized Controlled Trial, Veterinary
    我们的目标是评估完全替代微量矿物质的补充无机盐的影响(ITM;Co,Cu,Mn,硫酸锌和亚硒酸钠)由有机痕量矿物(OTM;Co,Cu,Mn,锌蛋白和硒化酵母)在产前和产后饮食中对体液和肝脏中TM浓度的影响,血液中的抗氧化剂和炎症生物标志物,和奶牛的产后健康。怀孕的母牛被胎次和BCS封闭,并在预期产卵前45天随机分配到ITM(n=136)或OTM(n=137)。除补充TM的来源外,两组均接受相同的产前和产后饮食。产卵日被认为是研究d〇,并且在d-45、-21、-14、-10、-7、-3、0、3、7、10、14、23、65和105收集血液用于TM和生物标志物的分析。还研究了肝脏中TM的浓度(第105天),牛奶(D7,23,65,105),尿液(d-21,21,65,105),瘤胃液和粪便(d-21,21,65)。评估了临床和亚临床健康状况的发生率。OTM完全替代ITM导致血清中硒浓度更高(0.084vs.0.086µg/mL;P<0.01),牛奶(0.24vs.0.31µg/g;P<0.01),和瘤胃液(0.54vs.0.58微克/克;P=0.06),并降低尿液中硒的浓度(1.54vs.1.23µg/g;P<0.01)。对于血清中Co的浓度,治疗与时间间存在交互作用(P<0.01)。补充OTM的奶牛在d-7和0时的Co浓度更高(0.30vs.0.33ng/mL;P<0.01),但在第23、65和105天的Co浓度较低(0.34vs.0.31ng/mL;P<0.05),除了降低粪便中Co的浓度(1.08vs.0.99微克/克;P=0.04)和,仅适用于多胎,在尿液中(0.019vs.0.014微克/克;P<0.01)。补充OTM的奶牛产后谷氨酸脱氢酶浓度较低(20.8vs.17.8U/L;P<0.05),d-10时白蛋白较高(36.0vs.36.7g/L;P=0.04)和23(36.9与37.6g/L;P=0.03)相对于产卵。饲喂OTM的初产母牛血浆中铜蓝蛋白的浓度较低(55vs.51mg/L;P≤0.05)。补充OTM的奶牛跛行发生率较低(14vs.7%;P=0.05),升高的NEFA(61vs.44%;P<0.01),和多种代谢问题(35vs.20%;P<0.01)。尽管铜缺乏差异,Mn,锌浓度和抗氧化能力,用OTM完全替代ITM,改变了Se和Co的浓度,支持肝脏和蹄的健康,并降低产后NEFA升高的风险。
    Our objectives were to evaluate the effects of complete replacement of supplementary inorganic salts of trace minerals (ITM; cobalt (Co), copper (Cu), manganese (Mn), zinc (Zn) sulfates and sodium (Na) selenite) by organic trace minerals (OTM; Co, Cu, Mn, Zn proteinates, and selenized yeast) in both pre- and postpartum diets on trace minerals (TM) concentrations in body fluids and liver, antioxidant and inflammation biomarkers in blood, and postpartum health of dairy cows. Pregnant cows were blocked by parity and body condition score and randomly assigned to ITM (n = 136) or OTM (n = 137) 45 d before expected calving. Both groups received the same pre- and postpartum diets except for the source of supplementary TM. The day of calving was considered study d 0 and blood was collected on d -45, -21, -14, -10, -7, -3, 0, 3, 7, 10, 14, 23, 65, and 105 for analyses of TM and biomarkers. Concentrations of TM were also investigated in the liver (d 105), milk (d 7, 23, 65, 105), urine (d -21, 21, 65, 105), ruminal fluid and feces (d -21, 21, 65). Incidence of clinical and subclinical health conditions were evaluated. Complete replacement of ITM by OTM resulted in greater concentration of selenium (Se) in serum (0.084 vs. 0.086 µg/mL; P < 0.01), milk (0.24 vs. 0.31 µg/g; P < 0.01), and ruminal fluid (0.54 vs. 0.58 µg/g; P = 0.06), and reduced concentration of Se in urine (1.54 vs. 1.23 µg/g; P<0.01). For concentration of Co in serum, an interaction between treatment and time was detected (P < 0.01). Cows supplemented with OTM had greater concentrations of Co on d -7 and 0 (0.30 vs. 0.33 ng/mL; P < 0.01) but lower concentrations of Co on d 23, 65, and 105 (0.34 vs. 0.31 ng/mL; P < 0.05), in addition to reduced concentration of Co in feces (1.08 vs. 0.99 µg/g; P = 0.04) and, for multiparous only, in urine (0.019 vs. 0.014 µg/g; P < 0.01). Cows supplemented with OTM had lower postpartum concentrations of glutamate dehydrogenase (20.8 vs. 17.8 U/L; P < 0.05) and higher albumin on d -10 (36.0 vs. 36.7 g/L; P = 0.04) and 23 (36.9 vs. 37.6 g/L; P = 0.03) relative to calving. Primiparous cows fed OTM had lower concentration of ceruloplasmin in plasma (55 vs. 51 mg/L; P ≤ 0.05). Cows supplemented with OTM had less incidence of lameness (14% vs. 7%; P = 0.05), elevated nonesterified fatty acids (NEFA) (61% vs. 44%; P < 0.01), and multiple metabolic problems (35% vs. 20%; P < 0.01). Despite the lack of differences in Cu, Mn, and Zn concentrations and antioxidant capacity, complete replacement of ITM by OTM altered concentrations of Se and Co, supported liver and hoof health, and reduced the risk of postpartum elevated NEFA.
    Trace minerals (TM) are important for oxidative balance and immunity of cows. Different forms of TM are available for dietary supplementation of dairy cows. We tested whether replacing inorganic salts of TM by organic sources of TM in both pre- and postpartum diets improve TM concentration in body fluids and liver, antioxidant capacity in blood, and postpartum health of dairy cows. Despite the lack of difference in antioxidant capacity and in concentrations of Cu, Mn, and Zn, the complete replacement of inorganic salts by organic sources altered concentrations of Se and Co in circulation, and reduced the concentration of biomarkers associated with inflammation and liver damage, and the risk of lameness and postpartum metabolic problems.
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  • 文章类型: Journal Article
    背景:移动健康,使用移动技术提供医疗保健,被发现在改变健康行为方面是有效的,包括改善产后妇女的母乳喂养做法。随着智能手机和即时通讯应用在香港的广泛使用,即时消息组可能是提供母乳喂养同伴支持的有用渠道。
    目的:本文的目的是研究由训练有素的同伴咨询师在香港建立在线即时消息同伴支持小组,以改善初产妇的母乳喂养结果的可行性和可接受性。
    方法:双臂,评估员-盲,将对40名初产妇进行母乳喂养的随机对照可行性研究。参与者从香港一家公立医院的产前妇产科诊所招募,并以1:1的比例随机分配到干预组或对照组。干预小组在一个在线即时消息小组中获得同伴支持,在标准护理之上,由训练有素的同伴顾问组成,而对照组接受标准护理。母乳喂养结果将在产后6个月或直至断奶后进行评估。母乳喂养状况,每组纯母乳喂养的比例和持续时间,并评估参与者的自我效能感和态度。该研究的可行性和可接受性也将在准备完整的随机对照试验时进行评估。
    结果:本研究(协议版本1,日期为2021年1月5日)已由香港大学机构审查委员会审查和批准,医院管理局香港西区联网(参考UW21-039),2021年1月26日数据收集正在进行中,预计将于2021年12月完成。研究结果将在临床试验注册中更新,并在同行评审的期刊上传播。
    结论:本研究旨在评估在线即时消息同伴支持小组在改善香港初产妇母乳喂养结果方面的可行性和有效性。其发现可以告知这种干预设计的全面试验的可行性。
    背景:ClinicalTrials.govNCT04826796;https://clinicaltrials.gov/ct2/show/NCT04826796。
    未经批准:DERR1-10.2196/32338。
    BACKGROUND: Mobile health, the use of mobile technology in delivering health care, has been found to be effective in changing health behaviors, including improving breastfeeding practices in postpartum women. With the widespread use of smartphones and instant messaging apps in Hong Kong, instant messaging groups could be a useful channel for delivering breastfeeding peer support.
    OBJECTIVE: The aim of this paper is to study the feasibility and acceptability of an online instant messaging peer support group by trained peer counselors on improving breastfeeding outcome in primiparous women in Hong Kong.
    METHODS: A two-arm, assessor-blind, randomized controlled feasibility study will be conducted on 40 primiparous women with the intention to breastfeed. Participants are recruited from the antenatal obstetrics and gynecology clinic of a public hospital in Hong Kong and randomly assigned at a 1:1 ratio to either intervention or control group. The intervention group receives peer support in an online instant messaging group with trained peer counselors on top of standard care, whereas the control group receives standard care. Breastfeeding outcome will be assessed for 6 months post partum or until weaned. The breastfeeding status, the proportion and duration of exclusive and any breastfeeding in each group, and the self-efficacy and attitude of participants will be assessed. The feasibility and acceptability of the study would also be assessed in preparation for a full randomized controlled trial.
    RESULTS: This study (protocol version 1 dated January 5, 2021) has been reviewed and approved by the institutional review board of the University of Hong Kong, Hospital Authority Hong Kong West Cluster (reference UW 21-039), on January 26, 2021. Data collection is ongoing and expected to be completed in December 2021. The findings will be updated on clinical trial registry and disseminated in peer-reviewed journals.
    CONCLUSIONS: This study aims to assess the feasibility and effectiveness of an online instant messaging peer support group in improving the breastfeeding outcome of primiparous women in Hong Kong. Its findings could inform the feasibility of a full-scale trial with this intervention design.
    BACKGROUND: ClinicalTrials.gov NCT04826796; https://clinicaltrials.gov/ct2/show/NCT04826796.
    UNASSIGNED: DERR1-10.2196/32338.
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  • 文章类型: Journal Article
    目的:我们估计平价医疗法案(ACA)医疗补助扩大对不同生育阶段育龄妇女医疗补助覆盖的影响。
    方法:使用来自美国社区调查(ACS)(n=1,977,098)的数据和差异差异方法,我们比较了没有孩子的低收入成年女性的医疗补助覆盖率,产后母亲,以及从扩张州到非扩张州的一岁以上儿童的母亲,在扩张之前和之后。
    结果:ACA的医疗补助扩展使收入在联邦贫困线(FPL)的101%至200%之间的成年女性的医疗补助覆盖率增加了10.7个百分点(54%,p<0.01)。有一岁以上子女的母亲的覆盖率增加了9.5个百分点(34%,p<0.01)。有婴儿的母亲的覆盖率上升了7.9个百分点(21%,p<0.01)。
    结论:在成年育龄妇女中,我们发现ACA的医疗补助扩大带来的影响“散开”。无子女妇女的覆盖率最大,而婴儿母亲的覆盖率最小;一岁以上儿童的母亲则处于中间。这些结果与ACA增益在ACA目标最少的组中最小一致,而且即使在产后母亲中也显示出可观的收益(五分之一)。
    OBJECTIVE: We estimate the effect of the Affordable Care Act\'s (ACA) Medicaid expansions on Medicaid coverage of reproductive-aged women at varying childbearing stages.
    METHODS: Using data from the American Community Survey (ACS) (n = 1,977,098) and a difference-in-differences approach, we compare Medicaid coverage among low-income adult women without children, postpartum mothers, and mothers of children older than one year in expansion states to non-expansion states, before and after the expansions.
    RESULTS: The ACA\'s Medicaid expansion increased Medicaid coverage among adult women with incomes between 101 and 200% of the federal poverty line (FPL) without children by 10.7 percentage points (54 percent, p < 0.01). Coverage of mothers with children older than one year increased by 9.5 percentage points (34 percent, p < 0.01). Coverage of mothers with infants rose by 7.9 percentage points (21 percent, p < 0.01).
    CONCLUSIONS: Within the population of adult reproductive-aged women, we find a \"fanning out\" of effects from the ACA\'s Medicaid expansions. Childless women experience the largest gains in coverage while mothers of infants experience the smallest gains; mothers of children greater than one year old fall in the middle. These results are consistent with ACA gains being the smallest among the groups least targeted by the ACA, but also show substantial gains (one fifth) even among postpartum mothers.
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