UNASSIGNED:本研究旨在探讨七氟醚和异丙酚对结直肠癌(CRC)患者术后恶心呕吐(PONV)的影响。七氟醚吸入麻醉具有诱导时间短,稳定的血液动力学,麻醉维持稳定,恢复时间短,它的麻醉效果与异丙酚相似,所以值得比较分析。
未经授权:PubMed,科克伦,WebofScience,Embase,本研究检索了2000年10月至2021年10月期间发表的关于七氟醚和异丙酚对CRC患者腹腔镜手术后恶心和呕吐的影响的随机对照试验(RCTs)数据.应用纳入标准,文献选择,数据提取,并对纳入的文章进行了质量评价评估。I2检验用于评估研究之间的异质性,使用Cochrane提供的RevMan5.2.6软件进行荟萃分析。
UNASSIGNED:本荟萃分析共纳入12项随机对照试验。术后心率变化差异有统计学意义[比值比(OR)=3.55,95%置信区间(CI):2.40,5.27,P<0.00001,I2=0%,Z=6.30],平均动脉压(MAP)(OR=2.58,95%CI:2.04,3.26,P<0.00001,I2=58%,Z=7.87),PONV的发生率(OR=1.73,95%CI:1.38,2.17,P<0.00001,I2=46%,Z=4.78),术后意识障碍的发生率(OR=2.09,95%CI:1.62,3.07,P<0.00001,I2=63%,实验组和对照组之间的Z=5.67)。
UNASSIGNED:七氟醚和丙泊酚联合麻醉对接受腹腔镜检查并具有中度中枢镇静作用的CRC患者的PONV具有良好的预防和治疗效果。
UNASSIGNED: This study sought to explore the effects of sevoflurane and propofol on postoperative nausea and vomiting (PONV) in patients with colorectal cancer (CRC). Sevoflurane inhalation anesthesia has the advantages of short induction time, stable hemodynamic, stable anesthesia maintenance and short recovery time, and its anesthetic effect is similar to that of propofol, so it is worthy of comparative analysis.
UNASSIGNED: The PubMed, Cochrane, Web of Science, Embase, clinical research register and CQVIP databases were searched to retrieve the data of randomized controlled trials (RCTs) published between October 2000 and October 2021 on the effects of sevoflurane and propofol on nausea and vomiting after laparoscopic surgery in patients with CRC. Applying the inclusion criteria, the literature selection, data extraction, and quality evaluation assessments were carried out for the included articles. The I2 test was used to evaluate the heterogeneity between the studies, and the meta-analysis was performed using RevMan 5.2.6 software provided by Cochrane.
UNASSIGNED: A total of 12 RCTs were included in this meta-analysis. There was statistically significant differences in changes in postoperative heart rate [odds ratio (OR) =3.55, 95% confidence interval (CI): 2.40, 5.27, P<0.00001, I2=0%, Z=6.30], mean artery pressure (MAP) (OR =2.58, 95% CI: 2.04, 3.26, P<0.00001, I2=58%, Z=7.87), the incidence of PONV (OR =1.73, 95% CI: 1.38, 2.17, P<0.00001, I2=46%, Z=4.78), and the incidence of postoperative disturbance of consciousness (OR =2.09, 95% CI: 1.62, 3.07, P<0.00001, I2=63%, Z=5.67) between the experimental group and the control group.
UNASSIGNED: Combining anesthesia with sevoflurane and propofol had good prevention and treatment effects for PONV in patients with CRC who underwent a laparoscopy and had a moderate central sedation effect.