背景:患有SARS-CoV-2感染的儿童在麻醉后并发症的风险增加。关于升高的并发症风险持续到最初的SARS-CoV-2诊断之后的时间,数据很少。
目的:我们调查了SARS-CoV-2感染患儿在诊断后90天内的麻醉后并发症。
方法:我们完成了单中心,回顾性,2020年1月3日至10月7日期间接受麻醉的90天内确诊SARS-CoV-2感染的儿科患者的病例对照研究。每个SARS-CoV-2阳性患者的年龄和手术类型与非SARS-CoV-2队列1:2匹配。主要结果是手术后30天内所有麻醉后并发症的发生率,定义为48小时内的计划外护理升级,心脏,呼吸,血栓形成,和30天内的出血性事件。次要结局是30天死亡率和住院时间。
结果:在纳入的341例患者中,SARS-CoV-2阳性114例,SARS-CoV-2阴性227例。麻醉前0-7天试验阳性的患者在30天内所有麻醉后并发症的风险差异增加(19.9,95%CI[4.7,35.1],p=.001)和住院时间的风险差异增加(7.8,95%CI[1.2,14.4],p<.001)。在SARS-CoV-2诊断后超过42天接受麻醉的患者在30天内心脏并发症的风险差异增加(4.3,95%CI[0.9,10.0],p=.029)。在麻醉前8天以上的SARS-CoV-2阳性患者中,住院时间没有增加。麻醉后30天内没有死亡。
结论:在SARS-CoV-2诊断后7天内接受麻醉的儿童,麻醉后并发症较高。额外的心脏风险可能持续超过初始诊断的直接时期。需要更大的样本来进一步评估延迟麻醉后并发症的风险并指导手术的最佳时机。
Children with SARS-CoV-2 infection are at increased risk for
postanesthesia complications. There is minimal data regarding how long that elevated complication risk persists beyond initial SARS-CoV-2 diagnosis.
We investigated
postanesthesia complications in children with SARS-CoV-2 infection within 90 days of diagnosis.
We completed a single-center, retrospective, case-control study of pediatric patients with confirmed SARS-CoV-2 infection within 90 days undergoing anesthesia between January 3-October 7, 2020. Each SARS-CoV-2 positive patient was matched 1:2 by age and type of procedure with a non-SARS-CoV-2 cohort. The primary outcome was the rate of all
postanesthesia complications within 30 days of the procedure, defined as unplanned escalations of care within 48 h, cardiac, respiratory, thrombotic, and hemorrhagic events within 30 days. Secondary outcomes were 30-day mortality and hospital length of stay.
Of the 341 patients included, 114 patients were SARS-CoV-2 positive and 227 were SARS-CoV-2 negative. Patients with a positive test 0-7 days prior to anesthesia had an increased risk difference in all postanesthesia complications within 30 days (19.9, 95% CI [4.7, 35.1], p = .001) and increased risk difference in length of hospital stay (7.8, 95% CI [1.2, 14.4], p < .001). Patients who underwent anesthesia greater than 42 days from SARS-CoV-2 diagnosis had an increased risk difference in cardiac complications within 30 days (4.3, 95% CI [0.9, 10.0], p = .029). There was no increased hospital length of stay among SARS-CoV-2 positive patients diagnosed greater than 8 days before anesthetic. There were no deaths within 30 days of anesthetic.
Postanesthesia complications are higher in children who undergo anesthesia within 7 days of SARS-CoV-2 diagnosis. Additional cardiac risk may persist beyond the immediate period of initial diagnosis. Larger samples are needed to further evaluate the risk of delayed
postanesthesia complications and guide optimal timing of surgery.