■在热烤架错觉中,参与者体验到类似灼痛的感觉。错觉是通过在交替的位置同时触摸温暖和凉爽的刺激而引起的。在中风后疼痛中,中央致敏是由多种因素引起的,包括脊髓丘脑损伤和肩部疼痛。因为热格栅错觉取决于中央机制,最近有人认为它可能是中枢致敏的有用指标。因此,我们假设,与那些不太可能出现中枢敏化的患者相比,更有可能出现中枢敏化的卒中后患者也更有可能出现疼痛和不适的热格栅感觉.然而,热烧烤错觉对卒中后患者的影响尚未有报道.在这项试点研究中,我们对中风后患者进行了热格栅错觉程序,并分析了临床体感功能与热格栅感觉之间的关系。我们还进行了脑部成像分析,以确定与热格栅感觉相关的脑部病变区域。
■20名卒中后患者(65.7±11.9岁)参加了这项研究。热格栅错觉程序执行如下:患者同时触摸八个充满水的铜条,调节水温以提供交替的温暖(40°C)和寒冷(20°C)刺激。
■在床边定量感觉测试中,疼痛和不适的热格栅感觉倾向于与卷起现象有关,不适的热格栅感觉也与丘脑外侧核的损伤有关。
■这些发现表明,热格栅错觉可能测量中央敏化,继发性大脑多动症可能会导致热格栅感觉增加。
UNASSIGNED: In the thermal grill illusion, participants experience a feeling similar to burning pain. The illusion is induced by simultaneously touching warm and cool stimuli in alternating positions. In post-stroke pain, central sensitization is caused by a variety of factors, including damage to the spinothalamic tract and shoulder pain. Because the thermal grill illusion depends on central mechanisms, it has recently been suggested that it may be a useful indicator of central sensitization. Therefore, we hypothesized that post-stroke patients who are more likely to experience central sensitization may also be more likely to experience a thermal grill sensation of pain and discomfort than the likelihood among those who are less likely to experience central sensitization. However, the effects of the thermal grill illusion in post-stroke patients have not yet been reported. In this pilot study, we conducted the thermal grill illusion procedure in post-stroke patients and analyzed the relationship between clinical somatosensory functions and thermal grill sensations. We also conducted brain imaging analysis to identify brain lesion areas that were associated with thermal grill sensations.
UNASSIGNED: Twenty patients (65.7 ± 11.9 years old) with post-stroke patients participated in this study. The thermal grill illusion procedure was performed as follows: patients simultaneously touched eight water-filled copper bars, with the water temperature adjusted to provide alternate warm (40°C) and cold (20°C) stimuli.
UNASSIGNED: Thermal grill sensation of pain and discomfort tended to be associated with the wind-up phenomenon in bedside quantitative sensory testing and thermal grill sensation of discomfort was also related to damage to the thalamic lateral nucleus.
UNASSIGNED: These findings suggest that the thermal grill illusion might measure central sensitization, and that secondary brain hyperactivity might lead to increased thermal grill sensations.