背景:COVID-19后状况(PCC)与许多精神病理学状况有关,包括突出的焦虑症状。然而,目前尚不清楚焦虑症状对PCC患者幸福感的影响.本研究旨在评估PCC患者焦虑与幸福感的关系。
方法:这是一个事后分析,利用来自安慰剂对照的数据,随机化,评估沃替西汀对PCC患者认知障碍影响的双盲临床试验(NCT05047952)。使用广义焦虑症量表收集有关焦虑和幸福感的基线数据,7项(GAD-7),和世界卫生组织(WHO)福祉指数,5-项目(WHO-5),分别。根据年龄对基线GAD-7和WHO-5评分进行广义线性模型(GLM)分析,性别,就业状况,教育水平,以前的重度抑郁症(MDD)诊断,并确认COVID-19病例为协变量。
结果:分析了144名参与者(N=144)的样本数据。在控制上述协变量后,结果发现GAD-7与WHO-5评分呈显著负相关(β=-0.053,p=<0.001),这表明焦虑增加对PCC患者的总体幸福感有不利影响.
结论:此处,我们在PCC患者中观察到有临床意义的焦虑水平.我们还确定了PCC中的焦虑与总体幸福感之间的强相关性。我们的结果需要复制,为推荐筛查和针对焦虑症状提供动力,作为改善PCC患者总体幸福感和结局的策略。
Post-COVID-19 condition (PCC) is associated with a host of psychopathological conditions including prominent anxiety symptoms. However, it is not known what effect anxious symptoms have on measures of well-being in individuals living with PCC. This study aims to evaluate anxiety\'s association with measures of well-being in people with PCC.
This is a post hoc analysis utilizing data from a placebo-controlled, randomized, double-blind clinical trial assessing the effect of vortioxetine on cognitive impairment in individuals with PCC (NCT05047952). Baseline data with respect to anxiety and well-being were collected using the Generalized Anxiety Disorder Scale, 7-Item (GAD-7), and the World Health Organization (WHO) Well-Being Index, 5-Item (WHO-5), respectively. A generalized linear model (GLM) analysis on baseline GAD-7 and WHO-5 scores was conducted with age, sex, employment status, education level, previous major depressive disorder (MDD) diagnosis, and confirmed COVID-19 cases as covariates.
Data was analyzed in a sample of 144 participants (N = 144). After controlling for the aforementioned covariates, the results found that GAD-7 and WHO-5 scores had a significant negative correlation (β = -0.053, p = <0.001), signifying that increased anxiety had adverse effects on the overall well-being of individuals with PCC.
Herein, we observed a clinically meaningful level of anxiety in individuals with PCC. We also identified a robust correlation between anxiety in PCC and measures of general well-being. Our results require replication, providing the impetus for recommending screening and targeting anxious symptoms as a tactic to improve general well-being and outcomes in individuals with PCC.