在这里,有效的抗菌多孔表面是通过呼吸图方法从含有低含量的具有高正电荷密度的嵌段共聚物的聚合物溶液中制备的。简而言之,那些嵌段共聚物,用作添加剂,由聚苯乙烯链段和带有1,3-噻唑和1,2,3-三唑基团的柔性侧链的大抗菌块组成,PS54-b-PTTBM-M44,PS54-b-PTTBM-B44,具有不同的烷基,甲基或丁基,分别。抗微生物嵌段共聚物以非常低的比例与商业聚苯乙烯共混,从3到9重量%,并溶解在THF中。从这些解决方案中,制备了用抗菌阳离子共聚物官能化的有序多孔膜,考察了烷基化剂和共聚物用量对共混物的影响。对于孔径在5和11μm之间的所有样品,获得窄孔径分布。孔的大小随着系统亲水性的增加而减小;因此,当共聚物的含量在共混物中增加时或当共聚物用甲基碘季铵化时。用低含量的抗微生物共聚物官能化的多孔聚苯乙烯表面对革兰氏阳性菌金黄色葡萄球菌表现出显著的抗菌效率,和假丝酵母作为微生物模型。
Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a large antimicrobial block bearing flexible side chain with 1,3-thiazolium and 1,2,3-triazolium groups, PS54-b-PTTBM-M44, PS54-b-PTTBM-B44, having different alkyl groups, methyl or butyl, respectively. The antimicrobial block copolymers were blended with commercial polystyrene in very low proportions, from 3 to 9 wt %, and solubilized in THF. From these solutions, ordered porous films functionalized with antimicrobial cationic copolymers were fabricated, and the influence of alkylating agent and the amount of copolymer in the blend was investigated. Narrow pore size distribution was obtained for all the samples with pore diameters between 5 and 11 µm. The size of the pore decreased as the hydrophilicity of the system increased; thus, either as the content of copolymer was augmented in the blend or as the copolymers were quaternized with methyl iodide. The resulting porous polystyrene surfaces functionalized with low content of antimicrobial copolymers exhibited remarkable antibacterial efficiencies against Gram positive bacteria Staphylococcus aureus, and Candida parapsilosis fungi as microbial models.