目的:放射性皮肤反应仍然是乳腺癌辅助放疗最常见的副作用之一。这是最常见的全球恶性肿瘤。在个别情况下,我们观察到用于皮肤标记的薄膜敷料下放射性皮炎的减少。因此,我们决定修订有关乳腺癌患者预防性使用薄膜敷料以减少放射性皮炎的现有证据.
方法:2023年3月20日,我们对发表在英文,德语,法语,或西班牙语,在PubMed数据库中可用。
结果:在82种出版物中,评估了9篇全文,并将6项随机对照试验纳入最终综合。两次试验分析了聚氨酯膜(Hydrofilm,保罗·哈特曼公司,海登海姆,德国),其他四种有机硅基聚氨酯薄膜(梅皮埃尔薄膜,Molnlycke医疗保健有限公司,米尔顿·凯恩斯,联合王国)。不良事件通用术语标准(CTCAE)放射治疗肿瘤组(RTOG),采用放射性皮肤反应评估量表(RISRAS)进行评估。所有六项试验,共有788名患者提供数据进行分析,通过使用该膜,证明辐射诱导的皮肤反应显著降低(主要p<0.001)。
结论:我们的分析表明,在乳腺癌患者中预防性应用薄膜敷料可显著减少辐射诱导的皮肤反应。随后预防性使用薄膜敷料可能会系统地减少这些患者的急性辐射引起的皮肤反应。
OBJECTIVE: Radiation-induced skin reactions remain one of the most frequent side effects of adjuvant radiotherapy for breast cancer, which is the most common global malignancy. In individual cases, we observed a decrease in radiation dermatitis under film dressings used for skin marking purposes. Therefore, we decided to revise the available evidence regarding the prophylactic use of film dressings to reduce radiation dermatitis in breast cancer patients.
METHODS: On 20 March 2023, we conducted a systematic review of literature for randomized controlled trials published in the English, German, French, or Spanish language, available in the PubMed database.
RESULTS: Of 82 publications, 9 full texts were assessed and 6 randomized controlled trials were included in the final synthesis. Two trials analyzed the application of polyurethane film (Hydrofilm, Paul Hartmann AG, Heidenheim, Germany), the other four of silicone-based polyurethane film (Mepitel film, Molnlycke Health Care Limited, Milton Keynes, United Kingdom). The evaluation scales Common Terminology Criteria for Adverse Events (CTCAE), Radiation Therapy Oncology Group (RTOG), and the Radiation-Induced Skin Reaction Assessment Scale (RISRAS) were used for assessment. All six trials, with a total of 788 patients yielding data for analysis, demonstrate a significant decrease in radiation-induced skin reactions by use of the film (mainly p < 0.001).
CONCLUSIONS: Our analysis demonstrates a significant decrease in radiation-induced skin reactions by prophylactically applied film dressings in breast cancer patients. Consequent preventive use of film dressings might systematically reduce acute radiation-induced skin reactions in these patients.