目的:随着再生注射材料在全球的临床应用日益广泛,人们越来越认识到聚-L-乳酸(PLLA)所起的关键作用.本研究的目的是对PLLA在面部护理临床应用中的疗效和安全性进行系统评价。
方法:我们对PubMed进行了搜索,EMBASE,WebofScience,和万方数据库,然后根据预定义的纳入和排除标准筛选检索到的文章.然后,我们对符合我们纳入标准的最终纳入文章进行了分析。在这些包括的文章中,使用Jadad量表进行随机对照试验(RCT)的质量评估,非随机对照试验(非随机对照试验)采用MINORS量表进行评价.
结果:我们对上述数据库的搜索,使用相关的搜索词,共发表了1300篇与PLLA相关的文章。在应用纳入和排除标准后,1280篇文章被排除在外。只有20篇文章,16个英文,4个中文,包括在我们的最终分析中,其中16个NRCT和4个RCT。根据不同的临床评价标准,PLLA的治疗取得了良好的效果。大多数PLLA注射相关的不良事件是轻度和自我限制的,没有任何额外的治疗要求。
结论:PLLA是一种合理安全有效的面部注射材料,可使用各种重组和注射方法应用于不同的面部注射区域和深度。
方法:本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述,请参阅目录或在线作者说明www。springer.com/00266.
OBJECTIVE: With the increasing global clinical application of regenerative injection materials, there is a growing recognition of the crucial role played by poly-L-lactic acid (PLLA). The aim of this study is to conduct a systematic review on the therapeutic efficacy and safety of PLLA in clinical applications for facial treatments.
METHODS: We conducted a search of the PubMed, EMBASE, Web of Science, and Wanfang databases, followed by screening of the retrieved articles based on predefined inclusion and exclusion criteria. We then performed an analysis on the final set of included articles that met our inclusion criteria. Within these included articles, quality assessment for randomized controlled trials (RCTs) was carried out using the Jadad scale, while non-randomized controlled trials (non-RCTs) were evaluated using the MINORS scale.
RESULTS: Our search of above database, using the relevant search terms, yielded a total of 1300 PLLA-related articles. After applying the inclusion and exclusion criteria, 1280 articles were excluded. Only 20 articles, 16 in English and 4 in Chinese, were included in our final analysis, among them 16 NRCTs and 4 RCTs. According to the different clinical evaluation standards, the treatment of PLLA has achieved good outcomes. Most PLLA injection-related adverse events are mild and self-limited, without any additional treatment requirement.
CONCLUSIONS: PLLA is a reasonably safe and effective facial injection material that can be applied in different facial injection areas and depth using various reconstitute and injection methods.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .