背景:雄激素性脱发是一种常见的遗传性疾病,其特征是进行性毛囊和毛发萎缩。尽管有所有可用的治疗技术,患者满意度低。似乎有必要为雄激素性脱发寻找新的治疗方案。在过去的十年里,富血小板血浆(PRP),具有止血和组织修复作用的浓缩血小板的自体集合,作为一种有价值的治疗技术,雄激素性脱发的治疗受到了越来越多的关注。
方法:在本研究中,招募了8名患有抗性雄激素性脱发的患者。制备PRP和血小板凝胶,使用23号注射器将总体积为10cc的PRP和血小板凝胶的组合注射到头皮雄激素相关区域。首次注射后1个月和3个月进行治疗(3次)。在治疗前进行毛发拉伸测试。结果在治疗后3、6和9个月通过毛发拉伸试验进行评估。皮肤镜,摄影,和病人的满意度。
结果:治疗前后观察到脱发的显着减少。毛发计数(密度)从平均数量72(毛发/cm2)增加到210毛发/cm2)。此外,所有患者治疗前后毛发直径均显著增加(p<0.05)。治疗后,8例患者的拉力试验明显下降(p<0.05)。
结论:本研究支持PRP和血小板凝胶联合治疗抗雄激素性脱发。这项技术并不复杂,可行,和具有成本效益的治疗选择抗性雄激素性脱发,患者满意度高。
BACKGROUND: Androgenic alopecia is a common genetic disorder that characterized by progressive hair follicles and hair atrophy. Despite all available therapeutic techniques, there is low patient satisfaction rate. It seems finding new treatment options for androgenic alopecia is necessary. In the past decade, platelet-rich plasma (PRP), an autologous collection of concentrated platelets with hemostatic and tissue repairing effects, has received developing attention for androgenetic alopecia treatment as a valuable therapeutic technique.
METHODS: In this study, 8 patients suffering from resistance androgenic alopecia were enrolled. The PRP and platelet gel were prepared, and a total volume of 10 cc of the combination of PRP and platelet gel were injected in the scalp androgen-related areas using 23-gauge syringe. The treatment was performed one month and 3 months after first injection (three times). The hair pull test was done before treatment. The outcome was evaluated 3, 6, and 9 months after treatment by hair pull test, dermoscopy, photography, and patient\'s satisfaction.
RESULTS: A significant reduction in hair loss was observed before and after treatment. Hair count (density) increased from average number of 72 (hair/cm2 ) to 210 hair/cm2 ). Also, the hair diameter was significantly increased before and after treatment for all patients (p < 0.05). After the treatment, the pull test was significantly decreased in 8 patients (p < 0.05).
CONCLUSIONS: This study supports the combination therapy of PRP and platelet gel for resistance androgenic alopecia treatment. This technique is an uncomplicated, feasible, and cost-effective treatment option for resistance androgenic alopecia, with high patient satisfaction.