背景:在中国人群队列中,利用职业紧张与胰岛素抵抗(IR)和2型糖尿病(T2D)发展的关联。
方法:2015年,来自北京功能社区队列的6109名参与者被纳入研究,随访至2021年。采用哥本哈根心理社会问卷(COPSOQ)对职业压力进行评估。
结果:在基线时,COPSOQ和总COPSOQ的所有五个量表的增加值与IR显着相关。在平均5.63年的随访中,732个人发展为T2D。“工作需求”的值增加,\"工作不安全\",“工作满意度”和总COPSOQ与T2D事件显着相关(P<0.01)。中介分析表明,主观感知的职业紧张主要通过影响血浆皮质醇和HOMA-IR的中介作用促进T2D,SBP,DBP,TG,尿素和UA对皮质醇和事件T2D之间的关联显着,介导比例为37.1%,8.12%,2.02%,2.94%,2.35%和2.70%。
结论:职业紧张与IR和T2D的发展独立相关。IR,BP,TG,尿素和UA均部分介导了职业压力与T2D事件之间的关联。
BACKGROUND: To exploit the association of occupational stress with the development of insulin resistance (IR) and type 2 diabetes (T2D) in a Chinese population-based cohort.
METHODS: A total of 6109 participants from a functional community cohort in Beijing were enrolled in 2015 and followed up until 2021. Copenhagen Psychosocial Questionnaire (COPSOQ) were used to evaluate occupational stress.
RESULTS: At baseline, increase values of all five scales of COPSOQ and total COPSOQ were significantly associated with IR. During an average 5.63 y follow-up, 732 individuals developed T2D. Increasing in values of \"Demands at work\", \"Insecurity at work\", \"Job satisfaction\" and total COPSOQ were significantly associated with incident T2D (P < 0.01). Mediation analysis showed that subjectively perceived occupational stress promoted T2D mainly by affecting plasma cortisol and the mediation effects of HOMA-IR, SBP, DBP, TG, Urea and UA were significant on the association between cortisol and incident T2D, with proportion mediated of 37.1%, 8.12%, 2.02%, 2.94%, 2.35% and 2.70%.
CONCLUSIONS: Occupational stress was independently associated with the development of IR and T2D. IR, BP, TG, Urea and UA all partly mediated the association between occupational stress and incident T2D.