进行了一项受控的新生仔猪试验,以评估与市售的基于乳制品的配方相比,以荞麦和杏仁为主要蛋白质来源的基于植物的婴儿配方对肠道健康参数的影响。两天大的仔猪饲喂基于植物的或基于乳制品的配方直到第21天。肠道微生物组,细胞因子,生长和代谢相关的结果,和肠道形态进行了评估,以确定基于植物的婴儿配方的安全性。该研究报道,基于植物的配方饲喂的仔猪相对于基于乳制品的配方饲喂组具有相似的肠道微生物群组成。然而,在小肠和大肠区域以及粪便样本中,在每个饮食组中检测到特定微生物群物种的差异丰度。乳杆菌,乳酸菌,和梭杆菌属。与基于乳制品的组相比,基于植物的配方饲喂仔猪的小肠中的丰度更高。Nordii拟杆菌,肠球菌。,卷曲乳杆菌,普雷沃特拉sp。,泌乳反肠球菌,Nordii拟杆菌,艾森伯氏菌。,卷曲乳杆菌,普雷沃特拉sp。,与以乳制品为基础的饮食组相比,以植物为基础的饮食喂养的仔猪的大肠中,粘液性Akkermansia的丰度更高。在粪便中,梭菌,均匀拟杆菌,Butyricimonasvirosa,泡状芽孢杆菌,梭状芽孢杆菌,和梭杆菌属。相对于植物性组,乳制品组丰富。落叶松科,scindens梭菌,大肠杆菌乳杆菌,和Prevetollasp.与基于乳制品的组相比,基于植物的组的粪便中的丰度更高。植物和基于乳制品的配方喂养的仔猪之间的肠道形态相似。循环细胞因子,镁,三碘甲状腺原氨酸(T3),甲状腺素(T4),促甲状腺激素(TSH),维生素D,维生素K,与饲粮组无关,所有仔猪的IgE水平相似。总的来说,本研究表明,与乳制品婴儿配方食品相比,以荞麦和杏仁为主要蛋白质来源的植物性配方食品可以支持相似的肠道微生物群生长和健康结果.
A controlled-neonatal piglet trial was conducted to evaluate the impact of a plant-based infant formula containing buckwheat and almonds as the main source of protein compared to a commercially available dairy-based formula on the gut health parameters. Two day old piglets were fed either a plant-based or a dairy-based formula until day 21. Gut microbiome, cytokines, growth and metabolism related outcomes, and intestinal morphology were evaluated to determine the safety of the plant-based infant formula. This study reported that the plant-based formula-fed piglets had a similar intestinal microbiota composition relative to the dairy-based formula-fed group. However, differential abundance of specific microbiota species was detected within each diet group in the small and large intestinal regions and fecal samples. Lactobacillus delbrueckii, Lactobacillus crispatus, and Fusobacterium sp. had higher abundance in the small intestine of plant-based formula-fed piglets compared to the dairy-based group. Bacteroides nordii, Enterococcus sp., Lactobacillus crispatus, Prevotella sp., Ruminococcus lactaris, Bacteroides nordii, Eisenbergiella sp., Lactobacillus crispatus, Prevotella sp., and Akkermansia muciniphila had greater abundance in the large intestine of the plant based diet fed piglets relative to the dairy-based diet group. In the feces, Clostridiales, Bacteroides uniformis, Butyricimonasvirosa, Cloacibacillus porcorum, Clostridium clostridioforme, and Fusobacterium sp. were abundant in dairy-based group relative to the plant-based group. Lachnospiraceae, Clostridium scindens, Lactobacillus coleohominis, and Prevetolla sp. had greater abundance in the feces of the plant-based group in comparison to the dairy-based group. Gut morphology was similar between the plant and the dairy-based formula-fed piglets. Circulatory cytokines, magnesium, triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), vitamin D, vitamin K, and IgE levels were similar among all piglets independent of dietary group. Overall, the present study demonstrated that a plant-based formula with buckwheat and almonds as the primary source of protein can support similar gut microbiota growth and health outcomes compared to a dairy-based infant formula.