■尿路致病性大肠杆菌(UPEC)引起的尿路感染(UTI)的发病机理涉及不同的毒力因子;因此,本研究旨在研究生物膜形成的患病率,毒力因子,通过系统评价和荟萃分析,UPEC分离株之间的系统发育群及其与生物膜形成的相关性。
■从2000年1日至2021年底,在不同的数据库中进行了文献检索,以根据PRISMA方案报道从UTI患者的UPEC分离物中的生物膜以及毒力基因或系统发育组。数据采用综合荟萃分析软件进行分析。
■生物膜形成剂的合并患病率为74.7%。系统发育群A的综合患病率,B1、B2和D(s)报告为19.6%,11%,50.7%,和20.5%,分别。全球报道的最常见的毒力基因是fimA,ecpA,还有FIMH,合并患病率为90.3%,86.6%,和64.9%,分别。具有系统发育组A的UPEC分离株中生物膜形成的合并患病率,B1、B2、D、C,F为12.4%,8.7%,33.7%,12.4%,2.6%,和2.65%,分别。几项研究表明,生物膜的产生与毒力基因之间存在相关性,或系统发育群体。
■关于获得的数据,结合生物膜形成的高水平(74.7%)和生物膜产生与毒力基因之间存在正相关,或本综述中大多数研究报告的系统发育组,表明生物膜在UTI中UPEC的持久性中起着重要作用。
UNASSIGNED: Different virulence factors are involved in the pathogenesis of urinary tract infection (UTI) caused by Uropathogenic Escherichia coli (UPEC); hence, this study aimed to study the prevalence of biofilm formation, virulence factors, and phylogenetic groups and their correlation with biofilm formation among UPEC isolates through a systematic review and meta-analysis.
UNASSIGNED: A literature search was conducted from 1, 2000, to the end of 2021 in different databases for studies that reported biofilm together with virulence genes or phylogenetic groups in UPEC isolates from patients with UTI according to PRISMA protocol. Data were analyzed by Comprehensive meta-analysis software.
UNASSIGNED: The pooled prevalence of biofilm formers was 74.7%. The combined prevalence of phylogenetic Groups A, B1, B2, and D (s) were reported at 19.6%, 11%, 50.7%, and 20.5%, respectively. The most common virulence genes reported worldwide were fimA, ecpA, and fimH, with a combined prevalence of 90.3%, 86.6%, and 64.9%, respectively. The pooled prevalence of biofilm formation in UPEC isolates with phylogenetic Groups A, B1, B2, D, C, and F were 12.4%, 8.7%, 33.7%, 12.4%, 2.6%, and 2.65%, respectively. Several studies showed a correlation between biofilm production and virulence genes, or phylogenetic groups.
UNASSIGNED: Regarding data obtained, the high level of combined biofilm formation (74.7%) and the presence of a positive correlation between biofilm production and virulence genes, or phylogenetic groups as reported by the most studies included in the present review, indicates an important role of biofilm in the persistence of UPEC in the UTI.