背景:性别确认生殖器手术是跨性别和非二元(TGNB)个体可用的几种外科手术之一,以改善其性别认同与出生时分配的性别之间的一致性。尽管越来越多地使用这些程序,用于评估确认性别的生殖器手术后主观结局的患者报告结局指标(PROM)仍然有限.我们的目的是提供目前用于评估TGNB患者在性别确认生殖器手术后的泌尿结局的PROM的概要,并评估每个PROM与TGNB患者相关的内容。
方法:使用包含变性人的搜索词进行了多数据库搜索(Embase和PubMed),患者报告的结果指标,问卷,和性别确认手术。回顾了评估性别确认生殖器手术后与泌尿结局和盆底功能障碍相关的主观结局的研究。确认性别的生殖器手术包括阴道重建(阴道成形术)和阴茎重建(阴茎成形术和子宫成形术)。对纳入的研究进行了相关内容项目的评估,并在表格中进行了总结。
结果:我们的文献检索确定了820篇独特文章。最终审查中包括了27篇完整文章。直到最近,测量工具仅限于为其他条件开发的未经验证的临时问卷或PROM,如尿失禁或阴道脱垂,这在以顺式性别为主的普通人群中得到了验证。在选定的研究中,用于评估性别确认生殖器手术后泌尿和盆底功能障碍的PROM包括自我构建的临时问卷(10项研究),阿姆斯特丹盆底过度活动症量表(四项研究),国王健康问卷(两项研究),盆底窘迫清单(PFDI)-20(两项研究),谢菲尔德盆腔器官脱垂(一项研究),尿失禁问题国际咨询问卷-尿失禁(ICIQ-UI)(一项研究),和ICIQ-女性下尿路症状(一项研究)。PFDI-20询问了生殖器手术后与TGNB患者最相关的症状;然而,并非所有经过cisgender验证的问卷都包含有关排尿职位的重要问题,张开或误导的流。确认手术表格和功能个人报告措施(AFFIRM)问卷是第一个用于评估TGNB个体的主观泌尿结果的PROM。GENDER-Q是一种有前途的新型PROM,旨在评估手术和其他性别确认治疗后的结局。
结论:尽管最近取得了进步,仍然需要标准化评估工具来评估确认性别的生殖器手术后的盆底功能障碍和泌尿症状.为普通人群开发的问卷调查评估盆腔器官脱垂和其他泌尿功能障碍的症状并不能完全捕获TGNB个体接受此类手术的独特经历。尽管如此,特别为TGNB个体验证的PROM对于更准确地评估性别确认生殖器手术的结果是必要的。允许知情的患者咨询,并创造以证据为基础的变化来改善这些干预措施。
BACKGROUND: Gender-affirming genital surgery is one of several surgical procedures available to transgender and nonbinary (TGNB) individuals to improve congruence between their gender identity and sex assigned at birth. Despite increasing utilization of these procedures, patient-reported outcome measures (PROMs) to assess subjective outcomes following gender-affirming genital surgery remain limited. Our aim was to provide a synopsis of PROMs currently being used to evaluate urinary outcomes among TGNB patients following gender-affirming genital surgery and to assess each PROM for content that is relevant to TGNB patients.
METHODS: A multidatabase search was performed (Embase and PubMed) using search terms that included transgender, patient-reported outcome measures, questionnaire, and gender-affirming surgery. Studies that assessed subjective outcomes related to urinary outcomes and pelvic floor dysfunction following gender-affirming genital surgery were reviewed. Gender-affirming genital surgery included vaginal reconstruction (vaginoplasty) and penile reconstruction (
phalloplasty and metoidioplasty). Included studies were evaluated for relevant content items and summarized in table.
RESULTS: Our literature search identified 820 unique articles. Twenty-seven full articles were included in the final review. Until recently, measurement tools have been limited to unvalidated ad hoc questionnaires or PROMs developed for other conditions, such as urinary incontinence or vaginal prolapse, that are validated among the predominantly cisgender general population. Of the selected studies, PROMs used to evaluate urinary and pelvic floor dysfunction following gender-affirming genital surgery included self-construced ad hoc questionnaires (10 studies), Amsterdam Overactive Pelvic Floor Scale (four studies), King\'s Health Questionnaire (two studies), Pelvic Floor Distress Inventory (PFDI)-20 (two studies), Sheffield Pelvic Organ Prolapse (one study), International Consultation on Incontinence Questionnaire-Urinary Incontinence (ICIQ-UI) (one study), and ICIQ-Female Lower Urinary Tract Symptoms (one study). The PFDI-20 asked about the most relevant symptoms to TGNB patients following genital surgery; however, not all cisgender validated questionnaires included important questions about voiding position, splayed or misdirected stream. The Affirming Surgery Form and Function Individual Reporting Measure (AFFIRM) questionnaire is the first PROM for assessing subjective urinary outcomes that are validated for TGNB individuals, and the GENDER-Q is a promising new PROM with the aim of evaluating outcomes following surgical and other gender-affirming treatments.
CONCLUSIONS: Despite recent advancements, a need remains for standardized assessment tools to evaluate pelvic floor dysfunction and urinary symptoms following gender-affirming genital surgery. Questionnaires developed for the general population to assess symptoms of pelvic organ prolapse and other urinary dysfunction do not fully capture the experiences unique to TGNB individuals undergoing this type of surgery. Nonetheless, PROMs validated specifically for TGNB individuals are necessary to more accurately evaluate outcomes of gender-affirming genital surgery, allow for informed patient counseling, and create evidence-based changes to improve these interventions.