目的:这项研究的目的是确定手足锻炼对化疗引起的周围神经病变相关疼痛严重程度的影响,falls,结直肠癌患者的生活质量。
方法:本研究于2022年4月25日至12月31日在一家公立医院的门诊化疗室进行。将39例患者随机分为干预组(n:19)和对照组(n:20)。将手脚锻炼计划应用于干预组,每天三次,每周三天,在家中连续8周。对照组除常规治疗和护理外,不进行其他干预。数据是在第一次采访和第二次采访中通过面对面采访收集的,第四,6th,第8周在第1-8周,通过电话/面对面访谈对干预组的锻炼计划依从性进行了随访。使用数字疼痛评分量表收集数据,秋季跟进表格,CIPNAT量表,EORTCQLQ-C30和EORTCQLQ-CR29量表。曼-惠特尼U测试,卡方检验,威尔科克森签署测试,采用Friedman检验对数据进行分析。
结果:研究发现,截至第4周,干预组疼痛严重程度低于对照组(p<0.001);在第8周,干预组周围神经病变症状较对照组下降(p<0.05);第2周,第四,6th,8th,跌倒差异无统计学意义(p>0.05);第8周,而结直肠癌患者的生活质量无显著差异(p>0.05),干预组总体癌症生活质量改善(p<0.05)。
结论:手脚锻炼计划对化疗引起的周围神经病变相关症状有效,疼痛严重程度,和整体癌症生活质量。
背景:www.
结果:政府,NCT05873829。
OBJECTIVE: The aim of this study is to determine the effect of hand-foot exercises on chemotherapy-induced peripheral neuropathy-related pain severity, falls, and quality of life in patients with colorectal cancer.
METHODS: The study was conducted in the outpatient chemotherapy unit of a public hospital between 25 April-31 December 2022. The enrolled 39 patients were randomly assigned to the intervention (n:19) and control (n:20) groups. The hand-foot exercises program was applied to the intervention group in three sessions a day and three days a week fashion for 8 weeks at home. No intervention was applied to the control group other than routine treatment and care. Data were collected through face-to-face interviews in the first interview and the 2nd, 4th, 6th, 8th weeks. The exercise program adherence of the intervention group was followed up through telephone/face-to-face interviews in weeks 1-8. Data were collected using the Numerical Pain Rating Scale, Fall Follow-Up Form, the CIPNAT scale, EORTC QLQ-C30 and EORTC QLQ-CR29 scales. Mann-Whitney U Test, Chi-square test, Wilcoxon signed test, and Friedman test were used to analyze the data.
RESULTS: The study found that as of week 4th, the intervention group experienced less pain severity than the control group (p < 0.001); at week 8th, the peripheral neuropathy symptoms of the intervention group decreased compared to the control group (p < 0.05); at weeks 2nd,4th,6th,8th, there was no statistically significant difference in falls (p > 0.05); at week 8th, while there was no significant difference between the groups regarding colorectal cancer quality of life (p > 0.05), the overall cancer quality of life improved in the intervention group (p < 0.05).
CONCLUSIONS: The hand-foot exercises program is effective in chemotherapy-induced peripheral neuropathy-related symptoms, pain severity, and overall cancer quality of life.
BACKGROUND: www.
RESULTS: gov, NCT05873829.