■确定患有围产期获得性HIV(YAPHIV)的年轻人的感知社会支持与病毒抑制之间的关系。
■我们将YAPHIV≥18年纳入AMPUp,一项关于PHACS(儿科HIV/AIDS队列研究)的研究,与社会支持评估和≥1HIV病毒载量(VL)在未来一年测量。我们评估了情绪,器乐,和友谊社会支持通过NIH工具箱。我们定义了社会支持,在研究进入和第3年测量(如果有的话),低(T分数≤40),平均(41-59)或高(≥60)。我们将病毒抑制定义为社会支持措施后一年内所有VL<50拷贝/mL。我们使用广义估计方程拟合多变量泊松回归模型,并评估了从儿科护理到成人护理的过渡作为效果调节剂。
■在444YAPHIV中,37%的人报告说,入境时的情感和工具支持和友谊很低,32%和36%。在接下来的一年里,44%被病毒抑制。在第3年数据的136人中,45%被压制。所有三种社会支持措施的平均水平或高水平与更高的病毒抑制可能性相关。在儿科患者中,仪器支持与病毒抑制相关(平均/高与低支持的患者中被抑制的调整比例=51.2%vs28.9%;风险比(RR)=1.77,95%置信区间(CI)=1.37,2.29),但不是成人护理(40.0%vs40.8%;RR=0.98,95%CI=0.67,1.44)。
■足够的社会支持增加了YAPHIV病毒抑制的可能性。随着YAPHIV为成人临床护理过渡做准备,增强社会支持的策略可能会促进病毒抑制。
UNASSIGNED: To determine the relationship between perceived social support and viral suppression among young adults with perinatally-acquired HIV (YAPHIV).
UNASSIGNED: We included YAPHIV ≥18 years enrolled in AMP Up, a study of PHACS (Pediatric HIV/AIDS Cohort Study), with social support evaluations and ≥1 HIV viral load (VL) measured over the next year. We evaluated emotional, instrumental, and friendship social support via the NIH Toolbox. We defined social support, measured at study entry and year 3 (if available), as low (T-score ≤40), average (41-59) or high (≥60). We defined viral suppression as all VL <50 copies/mL over the one year after social support measures. We fit multivariable Poisson regression models using generalized estimating equations, and evaluated transition from pediatric to adult care as an effect modifier.
UNASSIGNED: Among 444 YAPHIV, low emotional and instrumental support and friendship at entry were reported by 37%, 32% and 36%. Over the next year, 44% were virally suppressed. Of 136 with year 3 data, 45% were suppressed. Average or high levels of all three social support measures were associated with higher likelihood of viral suppression. Instrumental support was associated with viral suppression among those in pediatric (adjusted proportion suppressed among those with average/high vs low support=51.2% vs 28.9%; risk ratio (RR)=1.77, 95% confidence interval (CI)=1.37, 2.29), but not adult care (40.0% vs 40.8%; RR=0.98, 95% CI=0.67, 1.44).
UNASSIGNED: Sufficient social support increases likelihood of viral suppression among YAPHIV. Strategies to enhance social support may promote viral suppression as YAPHIV prepare for adult clinical care transition.