背景:胃食管反流病(GERD)和消化性溃疡(PUD)在台湾很普遍。很少有研究同时调查肥胖指数与GERD和PUD之间的关联。这项研究旨在调查肥胖指数与GERD和PUD之间的相关性。大约12万,在台湾生物库(TWB)。
方法:共纳入121,583名参与者(男性:43,698;女性:77,885;平均年龄49.9±11.0岁),以分析肥胖指数之间的关联。包括体重指数(BMI),腰臀比(WHR),腰围与身高比(WHtR),身体圆度指数(BRI),腹部容积指数(AVI),脂质积累产物(LAP),内脏肥胖指数(VAI)和甘油三酯-葡萄糖指数(TyG指数),GERD和PUD。通过问卷调查获得自我报告的GERD和PUD。采用多因素logistic回归分析肥胖指标与GERD、PUD的关系。
结果:GERD和PUD的患病率分别为13.7%和14.6%,分别。经过多变量分析,高WHR(赔率比[OR]=1.009,p<0.001),WHtR(OR=1.005,p=0.003),BRI(OR=1.022,p=0.005),AVI(OR=1.013,p<0.001),LAP(OR=1.001,p<0.001),TyG指数(OR=1.068,p<0.001)和VAI(OR=1.013,p=0.002)与GERD显著相关,BMI除外(p=0.384)。另一方面,低BMI(OR=0.984;p<0.001),AVI(OR=0.994;p=0.036)与PUD显著相关。然而,WHR的值(p=0.151),WHtR(p=0.304),BRI(p=0.452),LAP(p=0.799),VAI(p=0.347),和TyG指数(p=0.642)没有。
结论:这项研究发现高肥胖指数与GERD相关,但在一项大型台湾人群研究中,低肥胖指数与PUD相关。我们的发现可能会提醒医生注意不同的肥胖指数可能与不同的胃肠道疾病有关。
BACKGROUND: Gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD) are prevalent in Taiwan. Few studies have investigated the associations between obesity indices with GERD and PUD simultaneously. This study aimed to investigate the correlations among obesity indices with GERD and PUD in a large cohort of participants, around 120,000, in the Taiwan Biobank (TWB).
METHODS: A total of 121,583 participants (male: 43,698; female: 77,885; mean age 49.9 ± 11.0 years) were included to analyze the associations among obesity indices, including body mass index (BMI), waist-hip ratio (WHR), waist-to-height ratio (WHtR), body roundness index (BRI), abdominal volume index (AVI), lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose index (TyG index), with GERD and PUD. Self-reported GERD and PUD were obtained by questionnaires. Multivariate logistic regression analysis was employed to analyze the relationship between obesity indices with GERD and PUD.
RESULTS: The prevalence of GERD and PUD was 13.7% and 14.6%, respectively. After multivariable analysis, high WHR (odds ratio [OR] = 1.009, p < 0.001), WHtR (OR = 1.005, p = 0.003), BRI (OR = 1.022, p = 0.005), AVI (OR = 1.013, p < 0.001), LAP (OR = 1.001, p < 0.001), TyG index (OR = 1.068, p < 0.001), and VAI (OR = 1.013, p = 0.002) were significantly associated with GERD, except BMI (p = 0.384). On the other hand, low BMI (OR = 0.984; p < 0.001) and AVI (OR = 0.994; p = 0.036) were significantly associated with PUD. However, the values of WHR (p = 0.151), WHtR (p = 0.304), BRI (p = 0.452), LAP (p = 0.799), VAI (p = 0.347), and TyG index (p = 0.642) were not.
CONCLUSIONS: This study found that high obesity indices are associated with GERD, but low obesity indices are associated with PUD in a large Taiwanese population study. Our findings may alert physicians to notice that different obesity index may be associated with different gastrointestinal disorder.