■阴茎异常勃起是一种罕见的疾病,其特征是在没有性刺激的情况下阴茎持续勃起超过4小时,并与严重的发病率和并发症有关,包括勃起功能障碍和阴茎纤维化。阴茎异常勃起的手术治疗可能极具挑战性。我们在此提供全面的综述,旨在评估阴茎假体(PP)植入在阴茎异常勃起管理中的作用。
■使用以下数据库进行了系统的文献检索:PubMed,Embase,和Scopus来确定评估PP植入治疗阴茎异常勃起和长期并发症有效性的研究,结果,和患者满意度。
■在2002年至2022年之间发表的717项英语研究中,选择了17项进行此次审查。大多数患者使用了可延展的PP(MPP)植入物,在阴茎异常勃起发作后提前或延迟。PP的早期放置(EP)在不到72小时的研究之间被广泛定义,1周内,在3周内。阴茎异常勃起最常见的原因是镰状细胞性贫血(SCA),药物诱导,和特发性。研究表明,满意度在80%到100%之间,性交成绩在64.2%至100%之间。基于等级制度,纳入的研究被评为证据质量非常低。通常报告PP手术后出现的并发症,包括设备感染,侵蚀,曲率,和机械故障,比如自动通货膨胀。
■PP可以是阴茎异常勃起的有效治疗选择,特别是在持续超过36小时的缺血性阴茎异常勃起或医学上难治的复发性阴茎异常勃起的情况下。然而,由于证据质量很低,较大,在长期结果的情况下,精心设计的研究是必要的,患者满意度,和阴茎异常勃起相关PP植入后的并发症作为终点。
UNASSIGNED: Priapism is a rare condition characterized by persistent erection of the penis that lasts more than 4 hours in the absence of sexual stimulation and is associated with significant morbidity and complications, including erectile dysfunction and penile fibrosis. Surgical management of priapism can be extremely challenging. We herein provide a comprehensive review that aims to evaluate the role of penile prosthesis (PP) implantation in the management of priapism.
UNASSIGNED: A systematic literature search was performed using the following databases: PubMed, Embase, and Scopus to identify studies that evaluated the effectiveness of PP implantation in treating priapism and the long-term complications, outcomes, and patients\' satisfaction rate.
UNASSIGNED: Out of 717 English-language studies published between 2002 and 2022, 17 were chosen for this review. Majority of patients had a malleable PP (MPP) implant, either early or delayed after the priapism episode. Early placement (EP) of PP is widely defined between studies ranging from less than 72 hours, within 1 week, and within 3 weeks. Most common causes of priapism were sickle cell anemia (SCA), medication-induced, and idiopathic. Studies show a higher satisfaction rate ranging between 80% and 100%, with sexual intercourse achievement ranging between 64.2% and 100%. Based on the GRADE system, included studies rated as very low quality of evidence. Commonly reported complications that arise after PP procedures, include device infection, erosion, curvature, and mechanical malfunction, such as auto-inflation.
UNASSIGNED: PP can be an effective treatment option for priapism, particularly in cases of ischemic priapism lasting more than 36 hours or recurrent priapism that is medically refractory. However, due to the very low quality of evidence, larger, well-designed studies are warranted where long-term outcomes, patients\' satisfaction, and complications following priapism-related PP implantation are measured as endpoints.